Advanced Chemical Biology (eBook, PDF)

Chemical Dissection and Reprogramming of Biological Systems
Redaktion: Hang, Howard C.; Prescher, Jennifer A.; Pratt, Matthew R.

• Format: PDF

Produktbeschreibung

The book is organized around the central dogma of life, progressing from genes to proteins and higher-order cellular structures. Core application areas such as imaging, chemical genetics, activity-based protein profiling, and natural product discovery and biosynthesis are coverd in the core section of the book. Additional advanced topics and applications in, e. g., microbiology, developmental biology, and neurobiology are covered in the supplemental section. Every chapter is homogeneous in style and layout, consisting of a short historical introduction followed by a description of the underlying concepts and a selection of recent examples how the concept has been turned into practice. With its broad scope and focus on turning ideas into applications, this textbook will serve as a starting point for anyone entering the field and looking for a guide to the wide range of available methods and strategies that chemical biology has to offer.

---

Dieser Download kann aus rechtlichen Gründen nur mit Rechnungsadresse in D ausgeliefert werden.

Produktdetails

• Verlag: Wiley-VCH GmbH
• Erscheinungstermin: 3. Februar 2023
• Englisch
• ISBN-13: 9783527826292
• Artikelnr.: 67434572

Autorenporträt

Howard C. Hang, Ph.D. B.Sc. in Chemistry 1998, University of California, Santa Cruz (Joseph Konopelski) Ph.D. in Chemistry 2003, University of California, Berkeley (Carolyn Bertozzi) Damon Runyon Postdoctoral Fellow 2004 - 2006, Whitehead Institute (Hidde Ploegh) Assistant Professor and Head of Lab, 2007 - 2012, The Rockefeller University Associate Professor and Head of Lab, 2013 - present, The Rockefeller University Awards: Irma T. Hirschl/Monique Weill-Caulier Trust Research Award, 2007; Ellison Medical Foundation New Scholar Award, 2008; The Rockefeller University Distinguished Teaching Award, 2011; Eli Lilly Award in Biological Chemistry, 2017   Matthew R. Pratt, Ph.D. B.S. in Biochemistry and Math 1999, University of Arizona, Tucson (Robin Polt) Ph.D. in Chemistry 2004, University of California, Berkeley (Carolyn Bertozzi) American Cancer Society Fellow 2005-2009, Rockefeller University (Tom Muir) Associate Professor, University of Southern California, Los Angeles Awards: Damon Runyon Rachleff-Innovator (2011), USC General Education Teaching Award (2013), Susan G. Komen Career Catalyst Award (2014), American Cancer Society Research Scholar (2015), American Chemical Society - David Y. Gin Young Investigator Award (2015), American Cancer Society Hope Award (2016).   Jennifer A. Prescher, Ph.D. B.S. in Chemistry and Mathematics 2001, University of Wisconsin-La Crosse (Aaron Monte) Ph.D. in Chemistry 2006, University of California, Berkeley (Carolyn Bertozzi) Susan G. Komen and Molecular Imaging Fellow, Stanford University, 2007 - 2010 (Chris Contag) Assistant Professor, 2010 - 2016, University of California, Irvine Associate Professor, 2016 - 2018, University of California, Irvine Full Professor, 2018 - Present, University of California, Irvine Awards: Scialog Fellow (2018), UCI Distinguished Assistant Professor Award for Research (2016), ACS Women in Chemistry Rising Star (2016), Thieme Chemistry Journal Award (2016), Novartis Early Career Award in Organic Chemistry (2015), Camille and Henry Dreyfus Teacher-Scholar (2015), Alfred P. Sloan Research Fellowship (2015), NSF CAREER Award (2014), Cottrell Scholar (2014), Kavli Fellow (2014), UCI Outstanding Contributions to Undergraduate Education Award (2013)

Inhaltsangabe

Introduction to Advanced Chemical Biology
DNA Function, Synthesis and Engineering
Chemical Approaches to Genome Integrity
RNA function, synthesis, and probing
Chemical Approaches to Transcription and RNA Regulation In Vivo
Chemical Biology of Genome Engineering
Peptide Synthesis and Engineering
Protein Synthesis and Engineering
Directed Evolution for Chemical Biology
Chemical Biology of Cellular Metabolism
Chemical Biology of Lipids
Protein Post-Translational Modifications
Chemical Glycobiology
The Chemical and Enzymatic Modification of Proteins
Genetic Code Expansion
Bioorthogonal Chemistry
Cellular Imaging
In Vivo Imaging
Chemical Biology of Metals
Chemical Approaches Towards Redox Biology
Activity-Based Protein Profiling
Chemical Genetics
Natural Product Discovery
Natural Product Biosynthesis
Chemical Microbiology
Chemical Approaches to Analyze Biological Mechanisms and Overcome Resistance to Therapeutics
Chemical Developmental Biology
Chemical Immunology
Chemical Neurobiology
Small Molecule Drug Discovery

Rezensionen

Interessante Richtung des Lehrbuches, stärker aus chemischer Perspektive betrachtet. Erweitert dadurch den Blickwinkel aufs Fach gerade für Wissenschaftler die stärker aus der biologischen Richtung kommen.
Prof. Dr. David Kostner, Hochschule München, Biotechnologie (11/2023)