Advances in Cancer Research (eBook, ePUB)

• Format: ePub

Produktbeschreibung

Advances in Cancer Research, Volume 152, the latest release in this ongoing, well-regarded serial, provides invaluable information on the exciting and fast-moving field of cancer research. - Provides the latest information on cancer research - Offers outstanding and original reviews on a range of cancer research topics - Serves as an indispensable reference for researchers and students alike

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Produktdetails

• Verlag: Elsevier Science & Techn.
• Seitenzahl: 426
• Erscheinungstermin: 3. August 2021
• Englisch
• ISBN-13: 9780128241264
• Artikelnr.: 62364571

Autorenporträt

Professor & Chairman, Dept of Cell & Molecular Pharmacology John C. West Chair of Cancer Research, Medical University of South Carolina, USA
The Tew laboratory maintains an interest in using redox pathways as a platform to develop therapeutic strategies through drug discovery/development and biomarker identification. We interrogate how reactive oxygen and nitrogen species (ROS/RNS) impact cancer cells and develop novel drugs that impact on glutathione based pathways. Our research efforts have been integral to studies that have identified glutathione S-transferases (GST) as important in drug resistance, catalytic detoxification and as arbiters of kinase-mediated cell signaling events. In addition, we have been instrumental in defining how GSTP contributes to the process by which cells respond to ROS by selective addition of glutathione to specific protein clusters, so called S-glutathionylation. Each of these research areas has had broad impact on a number of cancer disciplines. Moreover, we have also been seminally involved in the Phase I to III clinical testing of three oncology drugs, Telcyta, Telintra and NOV-002. Other ongoing translational efforts have produced two ongoing clinical trials to measure the effectiveness of serum S-glutathionylated serine proteinase inhibitors as possible biomarkers for exposure to hydrogen peroxide mouthwashes and radiation.

Inhaltsangabe

1. Acetylcholinesterase and human cancers
Stephen D. Richbart, Justin C. Merritt, Nicholas A. Nolan, and Piyali Dasgupta
2. Head and neck cancer: Current challenges and future perspectives
Gh. Rasool Bhat, Rosalie G. Hyole, and Jiong Li
3. Metabolic control of cancer progression as novel targets for therapy
Sarmistha Talukdar, Luni Emdad, Rajan Gogna, Swadesh K. Das, and Paul B. Fisher
4. Targeting heat shock protein 90 for anti-cancer drug development
Anthony Aswad and Tuoen Liu
5. DNA methylation inhibitors: Retrospective and perspective view
Md Gias Uddin and Tamer E. Fandy
6. Roles of the tumor suppressor inhibitor of growth family member 4 (ING4) in cancer
Aymen Shatnawi, Dina I. Abu Rabe, and Daniel E. Frigo
7. Protein Tyrosine Phosphatases: A new paradigm in an old signaling system?
Colin L. Welsh, Preeti Pandey, and Lalima G. Ahuja
8. Cisplatin chemotherapy and renal function
Jie Zhang, Zhi-wei Ye, Kenneth D. Tew, and Danyelle M. Townsend
9. Astrocyte elevated gene-1 (AEG-1): A key driver of hepatocellular carcinoma (HCC)
Indranil Banerjee, Paul B. Fisher, and Devanand Sarkar
10. Reductive stress in cancer
Leilei Zhang and Kenneth D. Tew