José Marín-García

Aging and the Heart (eBook, PDF)

A Post-Genomic View

• Format: PDF

Produktbeschreibung

Cardiac aging, like aging in general, is a complex process. Numerous cellular and molecular changes contribute to the expression of the multiple phenotypes of aging, "the different faces" of cardiac aging. In this book, the genetic and molecular basis of cardiovascular aging is discussed. The work has been enabled by the availability of the Human Genome Project, and an ever increasing number of animal models as well as new and exciting molecular technologies. It can now be genuinely stated that the unraveling of the underlying basic mechanisms of cardiac aging have begun. The book also includes a comprehensive assessment of the bioenergetic changes that occur in human and animal models of cardiac aging as well as current diagnostic and future therapeutic modalities are undertaken.

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Produktdetails

• Verlag: Springer US
• Seitenzahl: 568
• Erscheinungstermin: 7. Dezember 2007
• Englisch
• ISBN-13: 9780387740720
• Artikelnr.: 37288007

Inhaltsangabe

to a Post-Genomic View of Aging and the Aging Heart.- Post-Genomic View of Aging: Definitions, Theories and Observations.- Overview of Cardiovascular Aging.- Methodologies, Cardiac Phenotypes and Adaptation.- Molecular and Cellular Methodologies: A Primer.- Molecular and Cellular Phenotypes of Cardiovascular Aging.- Aging of the Cardiovasculature and Related Systems.- Aging of the Vasculature and Related Systems.- Aging and the Cardiovascular-Related Systems.- Cardiovascular Diseases in Aging.- Cardiomyopathy and Heart Failure in Aging.- Atherosclerosis, Hypertension and Aging.- Metabolic Syndrome, Diabetes and Cardiometabolic Risks in Aging.- Gender and Cardiovascular Diseases in Aging.- Cardiac Dysrhythmias and Channelopathies in Aging.- Genetics.- Genetics of Life Span: Lessons from Model Organisms.- Profiling the Aging Cardiovascular System: Transcriptional, Proteomic, SNPs, Gene Mapping and Epigenetics Analysis.- Therapies.- Translational Research: Gene, Pharmacogenomics and Cell-Based Therapy in the Aging Heart.- Nutrition and Exercise in Cardiovascular Aging: Metabolic and Pharmacological Interventions.- The Future of Aging Research.- Aging and the Frontier Ahead.

Rezensionen

From the reviews: "A comprehensive and authoritative book about cardiac senescence in the postgenomic period. ... The book is extensively referenced and thoroughly researched. The bibliographies provided after each chapter are exhaustive, and the end of the book includes an ample glossary section defining the plethora of acronyms used throughout." (M. Saleem Seyal, JAMA, Vol. 300 (9), 2008) "This is a comprehensive review of basic science research in the field of aging in the context of clinically relevant cardiovascular disorders. ... It is intended for both basic scientists and clinicians with ... some experience in biochemistry, molecular and cell biology, and genetics who are interested in cardiovascular aging. ... The best features of this book are its comprehensiveness, with its numerous sources of research, and its integration of basic science research into relevant clinical topics." (Arindam Banerjee, Doody's Review Service, January, 2010)