Autoimmune Thyroiditis (eBook, PDF)

Approaches Towards its Etiological Differentiation
Redaktion: Scherbaum, Werner A.; Bottazzo, G. F.; Weinheimer, Balthasar; Bogner, Ulrich

• Format: PDF

Produktbeschreibung

This book summarizes current knowledge of thyroid autoimmunity. Some of the world's leading scientists in this field review recent data from four major subject areas: immunogenetics, thyroid peroxidase as an antigen, environmental factors, and cytokines. The discussions include much ongoing work that is not available in other sources.

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Produktdetails

• Verlag: Springer Berlin Heidelberg
• Seitenzahl: 308
• Erscheinungstermin: 6. Dezember 2012
• Englisch
• ISBN-13: 9783642763014
• Artikelnr.: 53152944

Inhaltsangabe

Immunogenetics.- New Insights into Autoimmune Mechanisms and the Pathogenesis of Insulin-Dependent Diabetes Mellitus.- Thyroid Antibodies and Thyroid Dysfunction in Patients with Type 1 Diabetes and Their First-Degree Relatives.- Association of HLA Class I and Class II Genes and Adrenal Steroid 21-Hydroxylase Gene with Subacute (de Quervain's) and Hashimoto's Thyroiditis: Evidence for an Altered Negative Feedback in Hashimoto's Thyroiditis.- Strongest Relative Risk for Goitrous Hashimoto's Thyroiditis Conferred by HLA-DQB1 Gene Variation.- A Search for Linkage Between Phenylthiocarbamide Tasting, the Kell Blood Group Locus and Autoantibodies to Thyroglobulin and Thyroid Peroxidase.- Autoimmune Thyroiditis: Its Implications with Other Organ Systems.- The Genetic Control of Thyroid Cell MHC Class II Antigen Expression.- Thyroid Peroxidase. Approaches Towards its Characterization.- Clinical Applications of Thyroid Peroxidase Autoantibody Determination.- Comparison Between Microsomal Antibodies by Immunofluorescence and Anti-TPO Antibodies in Healthy Individuals and Thyroid Autoimmune Disease.- Longitudinal and Cross-Sectional Studies on Anti-Thyroid Peroxidase Antibodies in Thyroid Disorders Compared to Conventional Anti-Microsomal Antibodies.- Comparison of New and Conventional Assay Techniques for Measuring Thyroid Microsomal Antibodies.- Further Clarification of the Significance of Thyroid Peroxidase Activity-Inhibiting Immunoglobulins in Autoimmune Thyroid Disease.- Biochemical Dissection of the Reactivity of TPO Antibodies.- T Cell Epitopes and Thyroid Peroxidase.- Thyroid Microsome/Thyroid Peroxidase Autoantigenic Epitopes Recognized by Autoantibodies Map to the Amino Terminal, the Central Core and the Carboxyl Terminal of the Molecule.- Comparison ofCirculating Thyroid Microsomal, Cytotoxic and Thyroid Peroxidase Antibodies.- Are TPO Antibodies and Cytotoxic Thyroid Antibodies Identical?.- Studies with Recombinant Autoepitopes of Thyroid Peroxidase.- Environmental Effects on the Development of Autoimmune Thyroiditis.- Mechanisms by Which Iodine Induces Autoimmunity.- Goiter and Autoimmune Thyroiditis in Iodine-Sufficient Areas.- Prevalence of Postpartum Thyroiditis in two Iodine-Deficient Regions of Germany.- An Immunosuppressive Factor Sharing Homology with P15E Protein of Leukomogenic Retroviruses is Present in the Serum of Patients with Graves' Disease.- Hashimoto's Thyroiditis and Enteropathogenic Yersinia enterocolitica.- Yersinia enterocolitica and Thyroid Disease.- In Vitro and In Vivo Effects of Cytokines.- Regulation of ICAM-1 Expression on Human Thyroid Follicular Cells.- Interleukin 6: A Pathogenic Factor in Autoimmune Thyroid Diseases?.- Endotoxins Do not Mimick the Effect of Interleukin-1 in Secondary Cultures of Human Thyroid Cells.- Blocking the Induction of HLA Class II Expression by Thyroid Epithelial Cells In Vitro.- Analysis of Intrathyroidal Cytokine Production in Thyroid Disease.- Lymphokine-Mediated Induction of HLA-DR Antigen Expression on Thyroid Follicular Cells In Vitro by Autologous Mononuclear Leukocytes and by Cytomegalovirus Infection.- Thyroid Dysfunction After High-Dose Interleukin-2 Therapy: An Update.- Human Recombinant Interleukin-ß Decreases Plasma Thyroid Hormone and TSH Levels in the Rat.- Thyroid Autoimmunity Induced by Interferon Therapy.- Effects of Interferon- ? and Interleukin-2 on Xenotransplanted Human Thyroid Tissue.- Closing Remarks.