BetaSys (eBook, PDF)

Systems Biology of Regulated Exocytosis in Pancreatic ß-Cells
Redaktion: Booß-Bavnbek, Bernhelm; Renström, Erik; Pociot, Flemming; Larsen, Jesper; Klösgen, Beate

• Format: PDF

Produktbeschreibung

The insulin secreting ß-cell is one of the most specialized cell types with diverse and multi-functional components (genes, gene products, organelles and metabolites) and a multitude of regulatory strategies in response to internal and environmental signals. This book looks at the technological advances that make simultaneous detection of thousands of biological variables possible; at a substantial variety of mathematical models and numerical simulations that aim to explain major aspects of the ß-cell function; and at the challenge to formulate a comprehensive and robust model of the main networks of the underlying biochemical and physical processes for diagnostic and therapeutic use.

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Produktdetails

• Verlag: Springer New York
• Seitenzahl: 556
• Erscheinungstermin: 2. März 2011
• Englisch
• ISBN-13: 9781441969569
• Artikelnr.: 37343094

Inhaltsangabe

Preface.- Systems biology of beta-cells - revisited.- Established facts and open questions of the focused systems analysis of regulated exocytosis in beta-cells - a background for a focused systems analysis approach.- Mitochondria and metabolic signals in beta-cells.- beta-cell ontogenesis and the insulin production apparatus.- The role of the cytoskeleton in transport and release of the insulin-containing granules by pancreatic beta-cells.- The mathematical microscope making the inaccessible accessible.- Magnetic resonance imaging of pancreatic beta-cells.- Mapping the beta-cell in 3D at the nanoscale using novel cellular electron tomography and computational approaches.- In vivo applications of inorganic nanoparticles.- Cell cultivation and sensor-based assays for dynamic measurements of cell vitality: basic concepts.- Bioimpedance spectroscopy.- DNA variations, impaired insulin secretion and type-2 diabetes.- Genetically programmed defects in beta-cell function.- Proteomic analysis of the pancreatic islet beta-cell secretory granule: current understanding and future opportunities.- Physiological and pathophysiological role of islet amyloid polypeptide (IAPP, amylin) - a role in the pathogenesis of type-2 diabetes.- Present state of islet transplantation for type-1 diabetes patients.- Predictive protein networks and identification of drugable targets in the beta-cell.- Nanotoxicity.- From silicon cell to silicon human.- Probing cellular dynamics with mesoscopic simulations.- What drives calcium oscillations in beta-cells? new tasks for cyclic analysis.- Whole-body and cellular models of glucose-stimulated insulin secretion.- Geometric and electromagnetic aspects of fusion pore making.- Index.

Rezensionen

From the reviews:
"This second volume is Springer's Systems Biology series focuses on the organisation of pancreatic insulin-producing beta cells, with a particular focus on the technological approaches deemed necessary to further our understanding of beta cell physiology and the pathogenesis of diabetes. ... I warmly recommend should be on the shelves of all research laboratories involved in modern beta cell research." (P. Meda, Diabetologia, Vol. 54, 2011)