Bioactive-Based Nanotherapeutics (eBook, ePUB)

Redaktion: Sindhu, Rakesh K.; Yapar, Evren Algin; Singh, Sumitra

• Format: ePub

Produktbeschreibung

The book provides essential insights into the revolutionary potential of nanotechnology in medicine, exploring innovative approaches that harness natural materials for targeted and effective disease management.

Nanotechnology has emerged as an innovative field with the potential to transform various sectors, including medicine and allied health sciences. Bioactive nanotherapeutics, a specific area within nanotherapeutics, utilizes natural materials or biomimetic designs to offer distinct advantages such as targeted drug delivery, biocompatibility, and improved therapeutic efficacy. These bioactive-based nanotherapeutics are used in the treatment and management of various diseases.

Bioactive-Based Nanotherapeutics explores this rapidly growing field of therapeutics. It presents a broad overview of the fundamentals of bioactive nanomaterials, their design strategies, and their therapeutic applications. Leading experts from different disciplines have contributed chapters that explore a diverse range of topics, including the basics of bioactive nanotherapeutics, isolation methods of different bioactive compounds, and formulation developments. This volume addresses the importance of nanotechnology for the treatment and management of different diseases, including nasal, gastrointestinal, rectal, and transdermal diseases.

Readers will find the book:

• Provides scientific research and evidence that supports the effectiveness of bioactive-based nanocarriers in treating diseases;
• Explores actionable steps and real-life scenarios to illustrate the practical benefits;
• Provides a comprehensive guide that explains the holistic approach, explaining health-related applications of bioactive-based nanoformulations.

Audience

Pharmacists, biologists, chemists, doctors, academics, and industry professionals interested in holistic and bioactive-based methods for disease treatment.

---

Dieser Download kann aus rechtlichen Gründen nur mit Rechnungsadresse in D ausgeliefert werden.

Produktdetails

• Verlag: John Wiley & Sons
• Seitenzahl: 1097
• Erscheinungstermin: 23. Juni 2025
• Englisch
• ISBN-13: 9781394287321
• Artikelnr.: 74732235

Autorenporträt

Rakesh K. Sindhu, PhD is a professor and a research and development co-coordinator in the School of Pharmacy at Sharda University, India, with 16 years of experience. He has filed 20 patents, five of which have been granted. He has also published over 90 papers in reputed journals, ten papers in international conferences, 30 in national conferences, eight books, and 25 book chapters. His research interests include pharmacological evaluation of herbal drugs and products, nanoformulation development and evaluation, standardization of herbal products, and phytochemical screening. Sumitra Singh, PhD is as a professor and dean in the Department of Pharmaceutical Sciences at the Guru Jambheshwar University of Science and Technology, India, with over 23 years of research and teaching experience. She has published over 50 research papers in reputed national and international journals, three books, and five book chapters. She has also filed five patents. Her expertise is in standardization, pharmacological evaluation, and formulation development of herbal drugs and natural products. Evren Algin Yapar, PhD is a professor, vice dean, and Head of the Department of Pharmaceutical Technology at Sivas Cumhuriyet University, Turkey. She is a member of the National Accreditation Council for Pharmacy Education and a several associations and professional organizations in addition to serving on several advisory and refer boards for international journals. She is involved in research regarding drug design and delivery, nanomaterials and carrier systems, cosmetics, herbal sources, and products.

Inhaltsangabe

Preface xxxi 1 Basics of Nano-Bioactive Compounds and Their Therapeutic Potential 1 Jannat ul Firdaus, Sumitra Singh and Rakesh K. Sindhu 1.1 Introduction 2 1.2 Therapeutic Potential of Bioactive Compounds 3 1.3 Extraction Techniques for Obtaining Bioactive Compound 8 1.4 Novel Delivery Approach for Bioactive Compounds 9 1.5 Electrospinning 11 1.6 Micro- and Nanoencapsulation of Bioactive Compounds 11 1.7 Polymeric Nanoparticles (NPs) 12 1.8 Solid Lipid Nanoparticles 12 1.9 Nanoemulsions 12 1.10 Nanocrystals 13 1.11 Phytosomes 13 1.12 Therapeutic Potential of Nano-Bioactive Compounds 14 1.13 Conclusion 17 References 18 2 Recent Techniques for Isolation of Bioactive Components from Plants 27 Omonike O. Ogbole, Oluwagbenga V. Kayode, Feranmi J. Adelowokan and Oluwatoyin A. Odeku 2.1 Introduction 28 2.2 Extraction Methods 30 2.3 Recent Chromatographic Methods 35 2.4 Applications of Two-Dimensional Chromatographic Approaches 40 2.5 Hyphenated Techniques 40 2.6 Conclusion 43 References 43 3 Bioactive-Based Nanocarriers for Inflammatory Diseases 55 Jasdev Singh Tuteja, Supriya Shidhaye, Anamika Singh and Tamanna Narsinghani 3.1 Inflammation and Diseases 56 3.2 Nanocarriers as Drug Delivery System 58 3.3 Nanocarriers and Inflammation 59 3.4 Inflammation in Central Nervous System 60 3.5 Ophthalmological Inflammation 63 3.6 Cardiovascular Inflammation 65 3.7 Respiratory Inflammation 68 3.8 Inflammation in Gastric System 73 3.9 Excretory System Inflammation 77 3.10 Inflammation of the Reproductive System 81 3.11 Inflammation Associated with Dermatology 85 3.12 Muscular Inflammation 89 3.13 Skeletal Inflammation 92 3.14 Applications of Nanocarriers in Inflammation 96 3.15 Conclusion 101 References 102 4 Bioactive-Based Nanocarriers for Dermal Diseases 115 Nitika Garg, Sanchit Dhankhar, Samrat Chauhan and Suresh Beniwal 4.1 Introduction 116 4.2 Skin Anatomy and Physiology: Implications for Drug Delivery 117 4.3 Barrier Functions of the Skin 119 4.4 Transdermal Permeation Challenges 119 4.5 Factors Influencing Dermal Drug Penetration 120 4.6 Role of Nanocarriers in Enhancing Drug Penetration 122 4.7 Types of Bioactive-Based Nanocarriers 129 4.8 Design Principles and Fabrication Techniques 129 4.9 Characterization of Bioactive-Based Nanocarriers 130 4.10 Applications in Diverse Dermal Diseases 132 4.11 Preclinical Studies: In Vivo and In Vitro 140 4.12 Challenges and Future Directions 142 4.13 Conclusion 143 References 144 5 Nano-Based Nasal Delivery of Biomacromolecules: A Myriad of Opportunities 151 Genada Sinani, Sevgi Güngör, Y
ld
z Özsoy and Erdal Cevher 5.1 Biomacromolecules 152 5.2 Characteristics of Biomacromolecules and Delivery Challenges 153 5.3 Opportunities of Nasal Route 156 5.4 Main Factors in Nasal Cavity Affecting Delivery of Biomacromolecules 157 5.5 Nano-Based Delivery Systems as an Efficient Strategy to Improve Intranasal Administration of Biomacromolecules 160 5.6 Proof of Concept: Biomacromolecules Administered by Intranasal Nano-Based Delivery Systems 167 5.7 Safety Considerations 184 5.8 Conclusion 185 References 187 6 Bioactive-Based Nanocarriers for Ocular Application 199 Ishita Bhardwaj, Atifa Haseeb Ansari, Swayam Prabha Rai, Durgesh Singh and Sippy Singh 6.1 Introduction 200 6.2 Barriers and Route of Ocular Drug Delivery 200 6.3 Nanoparticles in Ocular Diseases Therapy 201 6.4 Organic Nanocarriers 202 6.5 Inorganic Nanocarriers 207 6.6 Benefits of Bioactive-Based Nanoparticles for Occular Application 210 6.7 Challenges and Future Considerations 211 6.8 Conclusion 212 Acknowledgment 212 References 213 7 Bioactive-Based Nanocarriers for Gastrointestinal System Disease 223 Phool Chandra, Rashmi Pathak, Neetu Sachan, Ashok Kumar Gupta and Anurag Verma 7.1 Introduction 224 7.2 Types of Bioactive-Based Nanocarriers 231 7.3 Design and Fabrication of Bioactive-Based Nanocarriers 236 7.4 Bioactive Molecules for Targeting Gastrointestinal Diseases 238 7.5 Preclinical Studies and Clinical Trials 242 7.6 Therapeutic Applications of Bioactive-Based Nanocarriers 245 7.7 Safety and Toxicity Considerations 250 7.8 Challenges and Future Perspectives 253 7.9 Conclusion 254 References 255 8 Bioactive-Based Nanocarriers for Cancer Treatment and Targeting 265 Petra O. Nnamani, Ozioma B. Onokala and Oluwatoyin A. Odeku 8.1 Overview of Current Global Epidemiology and Prevalence of Cancer 266 8.2 Comparison and Contrast Between Bioactive
Based Nanocarriers and Other Cancer Treatment 266 8.3 Mechanism(s) for Cancer Treatment and Targeting Using Bioactive Compounds 270 8.4 Bioactive-Based Nanocarriers for Treatment and Targeting of Different Categories of Cancer 277 8.5 Limitations of Bioactive-Based Nanocarriers for Cancer Treatment and Targeting 285 8.6 Future prospects 285 8.7 Conclusion 286 References 286 9 Bioactive-Based Nanocarrier for the Management of Infectious Diseases 299 Manisha Pandey, Pooja, Deepika Sharma, Sunita Nirban, Ashwani Arya, Suchitra Nishal, Manish Dhall, Neha Jain and Tarun Kumar 9.1 Introduction 300 9.2 Factors Influencing Bioactive Nanocarriers 304 9.3 Mechanism of Action of Bioactive Nanocarriers in Infection 307 9.4 Recent Advancements in Bioactive-Based Nanocarrier for Infections 314 9.5 Beneficial Aspects of Bioactive-Based Nanocarrier Over Conventional Treatment 323 9.6 Conclusion and Future Prospects 329 References 329 10 Bioactive-Based Nanocarriers for Cosmeceuticals 339 Bhavana Singh, Gautam Kumar, Vandana, Hema Arya, Deepika Joshi, Urvashi Saxena, Sumitra Singh and Rakesh K. Sindhu 10.1 Introduction 340 10.2 Nanotechnology in Cosmeceuticals 342 10.3 Bioactive Ingredients in Cosmeceuticals 346 10.4 Nanocarriers for Bioactive Delivery 351 10.5 Applications of Bioactive-Based Nanocarriers in Cosmeceuticals 354 10.6 Challenges and Future Perspectives 361 References 364 11 Bioactive-Based Nanocarriers for CVD 369 Swapnali Patil, Pranali Pangam and Poournima Sankpal 11.1 Introduction 370 11.2 The Ongoing CVD Crisis 370 11.3 Bioactive Compounds and Their Role in Cardiovascular Disease (CVD) Prevention and Treatment 374 11.4 Role of Bioactive Compounds in CVD Prevention 374 11.5 Bioactive-Based Nanocarriers for Enhanced Drug Delivery 377 11.6 Challenges and Future Directions 380 11.7 Conclusion 383 References 384 12 Bioactive-Based Nanocarriers for Diabetes 389 Deepak Kumar, Ankit Kumar Singh, Adarsh Kumar, Harshwardhan Singh, Jagat Pal Yadav and Pradeep Kumar Abbreviations 390 12.1 Introduction 390 12.2 Bioactive-Based Nanocarriers in Medicine and Healthcare Including Diabetes 394 12.3 Significance of Material Selection in Bioactive-Based Nanocarriers 399 12.4 Targeting Strategies for Diabetes Therapy 399 12.5 Benefits of Targeted Drug Delivery in Diabetes 401 12.6 Factors Affecting Drug Loading Efficiency and Stability in Encapsulation Systems 403 12.7 Opportunities for Improving Nanocarrier Performance and Targeting Specificity 406 12.8 Ethical and Regulatory Considerations 407 12.9 Challenges and Future Perspectives 409 12.10 Conclusion 410 Acknowledgments 410 References 411 13 Bioactive-Based Nanocarriers in Management of CNS Diseases 417 Satish Polshettiwar, Pankaj Khuspe, Amol Gholap, Prasad Aldar and Mangesh Godbole 13.1 Introduction 418 13.2 Principles of Bioactive-Based Nanocarriers 422 13.3 Overcoming the Blood-Brain Barrier 428 13.4 Nanocarriers of Hope: Revolutionizing Neurodegenerative Disease Management 435 13.5 Applications in Neurodegenerative Diseases 436 13.6 Bioactive-Based Nanocarriers for Brain Tumor Therapy 438 13.7 Bioactive-Based Nanocarriers in Stroke Management 439 13.8 Traumatic Brain Injury and Nanocarrier Interventions 440 13.9 Imaging and Diagnostic Capabilities 441 13.10 Current Preclinical and Clinical Advancements 442 13.11 Future Prospects and Challenges 443 13.12 Conclusion 444 References 445 14 Nanocarrier Applications for the Delivery of Bioactives for Topical Wound Healing 461
mren Esentürk-Güzel, Merve Nur Özdemir, Evren Alg
n Yapar and Meryem Sedef Erdal 14.1 Introduction 462 14.2 Physiology of Wound Healing 463 14.3 Skin Drug Delivery for Wound-Healing Applications 465 14.4 Research on Wound Healing Using Nanocarriers Loaded with Bioactive Materials 468 14.5 Prospects and Challenges of Nanocarriers in Future Wound Healing 493 References 494 15 Bioactive-Based Nanocarriers for Targeting Antimicrobial Resistance 509 Paka Sravan Kumar, Farmiza Begum, Chaman Bala, Bhavana Singh, Rakesh Kumar Sindhu and Gautam Kumar 15.1 Introduction 510 15.2 Development of Antibiotic Resistance 510 15.3 Mechanism of Antibiotic Resistance 511 15.4 Current Treatment Approaches to Management Antibiotic Resistance and Challenges 514 15.5 Phytochemicals in the Management of Antibiotic Resistance 517 15.6 Phytochemical-Based Nanocarriers for the Management of Antibiotic Resistance 520 15.7 Mechanism of Phytochemical-Based Nanocarriers in Combating Antibiotic Resistance 521 15.8 Conclusion and Future Perspectives 522 References 522 16 Bioactive Phytochemical-Based Nanocarriers for Targeting Non-Alcoholic Fatty Liver Disease (NAFLD) 525 Gautam Kumar, Sara Fathima, Prasada Chowdari Gurram, Chaman Bala, Rakesh Kumar Sindhu and Farmiza Begum 16.1 Introduction 526 16.2 Etiology and Pathophysiology 526 16.3 Current Treatment Options Available for NAFLD 528 16.4 Bioactive-Based Nanocarriers: A Treatment Option for NAFLD as Smart Drug Carriers 541 16.5 Toxicological Concerns of Nanocarriers for NAFLD Therapy 548 16.6 Merits and Demerits of Bioactive-Based Nanocarriers for NAFLD Treatment 550 16.7 Conclusion and Future Perspectives 551 References 552 17 Bioactive Peptide-Based Nanocarrier and Its Application 563 Sailee Chowdhury, Subhabrota Majumdar, Dipanjan Karati, Koyel Kar and Rana Mazumder 17.1 Introduction 564 17.2 Brief Attention on Peptides 564 17.3 Bioactive Peptide as Nanocarriers 565 17.4 Conclusion and Future Outlook 577 References 578 18 Bioactive-Based Nanocarriers for the Treatment of Lung Disorders 587 Shayeri Chatterjee Ganguly, Sumon Giri and Moumita Kundu 18.1 Introduction 588 18.2 Advantages and Challenges of Nanocarriers in Lung Disease Treatment 589 18.3 Role of Bioactive Nanocarriers in Lung Disease Management 590 18.4 Bioactive-Based Nanocarriers in Asthma Management 591 18.5 Bioactive-Based Nanocarriers in COPD Treatment 595 18.6 Pulmonary Fibrosis and Bioactive Nanocarrier Approaches 598 18.7 Bioactive Nanocarriers for Cystic Fibrosis Treatment 600 18.8 Tuberculosis Management with Bioactive-Based Nanocarriers 603 18.9 Future Perspectives and Conclusion 605 References 606 19 Bioactive-Based Nanotherapeutics in Pain Management: A Revolutionary Approach 619 Sumon Giri, Zainab Irfan, Shaikh Ershadul Haque, Shayeri Chatterjee Ganguly and Stabak Das 19.1 Introduction 619 19.2 Pathophysiology of Pain 620 19.3 Pain Biomarkers 622 19.4 Treatment for Pain Management 627 19.5 Significance of Bioactive Compound-Based Nanotherapeutics in Pain Therapy 629 19.6 Nanotherapeutics: A New Strategy from the Bioactive Compounds for the Treatment of Pain 632 19.7 Conclusion 647 References 648 20 Bioactive-Based Nanocarriers for Neonatal Drug Delivery System: Enhancing Efficacy and Safety in Neonatal Medicine 663 A. Mohamed Noufal, R. Sabitha and S. Akilandeswari 20.1 Introduction 664 20.2 Nanocarrier Design Considerations for Neonatal Use 665 20.3 Bioactive Components in Nanocarrier Systems 667 20.4 Enhancing Drug Encapsulation, Stability, and Sustained Release 670 20.5 Minimizing Toxicity and Immunogenicity 672 20.6 Exploiting Neonatal Physiology for Targeted Delivery 674 20.7 Nanocarrier Surface Modification and Ligand Conjugation 675 20.8 Improving Drug Bioavailability in Neonatal Populations 678 20.9 Promising Applications of Bioactive-Based Nanocarriers in Neonatal Medicine 679 20.10 Advancements and Future Perspectives 681 20.11 Conclusion 681 References 682 21 Bioactive-Based Nanocarriers for the Treatments of Obesity: A Novel Approach 691 Loveleen Kaur, Baljinder Singh, Raghav Tandon, Reecha Madaan, Rakesh K. Sindhu and Sumitra Singh 21.1 Introduction 692 21.2 Pathophysiology 693 21.3 Management of Obesity 695 21.4 Bioactive Compounds 699 21.5 Nanotechnology 701 21.6 Conclusion/Future Perspectives 704 References 705 22 Regulatory Aspects of Bioactive-Based Nanocarriers 715 Farmiza Begum, Chaman Bala, Fathima Beegum, Sara Fathima, Rakesh Kumar Sindhu and Gautam Kumar 22.1 Introduction 716 22.2 The Necessity of Regulating Nanomedicine 717 22.3 Worldwide Strategies for the Regulation of Nanopharmaceuticals 717 22.4 Conclusion 724 References 725 Index 727