Biomarker Methods in Drug Discovery and Development (eBook, PDF)

Redaktion: Wang, Feng

• Format: PDF

Produktbeschreibung

In this book, expert researchers provide a tool box for those who have a general interest in biomarker research and for those currently specializing in certain technologies but desiring an understanding of other available methodologies. Its chapters include validated, mature methods as well as new, incredibly promising protocols which aim to apply multiple technologies at different molecular levels in order to surmount the monumental and complex task of transforming the pharmaceutical research and development processes. As a volume in the Methods in Pharmacology and Toxicology(TM) series, this book offers user-friendly, step-by-step laboratory protocols for readily reproducible experiments. Comprehensive and state-of-the-art, this is the perfect biomarker technical guideline and reference to stimulate more exciting biomarker research and technology development.

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Produktdetails

• Verlag: Humana Press
• Seitenzahl: 396
• Erscheinungstermin: 13. Februar 2008
• Englisch
• ISBN-13: 9781597454636
• Artikelnr.: 64611987

Inhaltsangabe

Biomarker Sample Collection and Handling in the Clinical Setting to Support Early-Phase Drug Development.- Gene Expression-Based Biomarkers of Drug Safety.- Profiling Gene Expression Signatures Using Fluorescent Microspheres.- Real-Time Polymerase Chain Reaction Gene Expression Assays in Biomarker Discovery and Validation.- SAGE Analysis in Identifying Phenotype Single Nucleotide Polymorphisms.- Single Nucleotide Polymorphisms and DNA Methylation Analysis Using Pyrosequencing Methods.- The Application of Laser Capture Microdissection for the Analysis of Cell-Type-Specific Gene Expression in a Complex Tissue:.- The Use of Two-Dimensional Gel Electrophoresis for Plasma Biomarker Discovery.- Difference In-Gel Electrophoresis: A High-Resolution Protein Biomarker Research Tool.- Label-Free Mass Spectrometry-Based Protein Quantification Technologies in Protein Biomarker Discovery.- Top-Down Quantitative Proteomic Analysis Using a Highly Multiplexed Isobaric Mass Tagging Strategy.- SELDI Technology for Identification of Protein Biomarkers.- Sandwich ELISA Microarrays: Generating Reliable and Reproducible Assays for High-Throughput Screens.- LC-MS Metabonomics Methodology in Biomarker Discovery.- GC-MS-Based Metabolomics.- NMR-Based Metabolomics for Biomarker Discovery.- Unraveling Glycerophospholipidomes by Lipidomics.

Rezensionen

From the reviews:

"... extremely useful to pharmaceutical scientists who are involved in research all the way from early drug discovery through clinical trials." - Doody's Book Review

"The book is ... for the bench scientist and is full of helpful advice on how to achieve high quality data using up-to-date technical approaches in genomics, proteomics and metabonomics. ... I warmly recommend this ... to all practicing toxicologists." (Roy Forster, British Toxicological Society Newsletter, June-August, 2009)