Biomarkers in Bipolar Disorders (eBook, ePUB)

Redaktion: Machado-Vieira, Rodrigo; Soares, Jair

• Format: ePub

Produktbeschreibung

Biomarkers in Bipolar Disorders summarizes cutting-edge findings in biomarkers' research, emphasizing the most promising findings, tools and technologies relevant to drug development and personalized medicine. Key findings cover different levels of evidence such as genes, molecules, cells, systems, brain and behavior related to diagnosis (state and trait/endophenotypes), prediction of treatment response and follow-up outcomes, along with the most promising perspectives in each area. Each section includes a comprehensive and focused overview on the state-of-the-art and perspectives. The book concludes with a section on practical applications, encompassing diagnostics development (genetic testing, biomarkers), and new drug development.

Edited by Dr. Rodrigo Machado-Vieira and Dr. Jair C. Soares, and contributed by leading experts in the field of biomarker research, this book will be become the leading tool for all researchers and clinicians in Bipolar Disorder.

• Describes strategies for the biomarker discovery of relevant proteins differentially expressed in Bipolar Disorder
• Presents techniques and main findings in transcriptome research related to CNS synaptic function
• Provides an overview on current behavioral strategies and their validity in drug development in Bipolar Disorder
• Discusses current genetic findings, integrating tests for treatments leading to personalized treatments

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Produktdetails

• Verlag: Elsevier Science & Techn.
• Seitenzahl: 528
• Erscheinungstermin: 16. Januar 2022
• Englisch
• ISBN-13: 9780128213995
• Artikelnr.: 63306241

Autorenporträt

Rodrigo Machado-Vieira, MD, PhD, MSc, is a Professor of Psychiatry and Director of the Experimental Therapeutics and Molecular Pathophysiology Program at the University of Texas, UTHealth, Houston. He was previously at the Intramural National Institute of Mental Health (NIMH), where he was the Director of the Translational Research Clinic in Mood Disorders at the Experimental Therapeutics and Pathophysiology Branch. Machado-Vieira received his MD from PUC-RS in Porto Alegre, Brazil and his PhD in Psychiatry at the University of Sao Paulo, following his Residency Training in Psychiatry. After a postdoctoral fellowship at the Laboratory of Molecular Pathophysiology and Experimental Therapeutics at NIMH, he led the Mood Disorders Program, LIM-27 at the Institute of Psychiatry, University of Sao Paulo, Brazil. Dr. Machado-Vieira has received several grants and Awards for his research on Mood Disorders including the National Institutes of Health Fellows Award for Research Excellence, t

he Brazilian Psychiatric Association Award, the Gerald Klerman Young Investigator Award, Depression and Bipolar Support Alliance (DBSA), Sao Paulo Young Investigator Research Award, and the Stanley Medical Research Institute Research Award. He was Chair of the Nominating Committee of the International Society for Bipolar Disorders (ISBD). Dr. Machado-Vieira published more than 200 articles published and over 12,500 citations.

Inhaltsangabe

1. Biomarkers in Bipolar Disorder: Overview
2. RNA and Micro-RNA Biomarkers in Bipolar Disorder
3. Metabolomics in Bipolar Disorder
4. Behavioral Models of Bipolar Disorder
5. Structural Neuroimaging in Bipolar Disorder
6. Neurochemical Imaging Findings in Bipolar Disorder
7. Pharmacogenomics and Precision Psychiatry in Bipolar Disorder
8. Translating Biomarkers from Bench to Bedside in Bipolar Disorder
9. Genetic (GWAS) Biomarkers in Bipolar Disorders
10. Mitochondrial Dysfunction in Bipolar Disorder
11. Aging Mechanisms in Bipolar Disorder
12. Staging and Neuroprogression in Bipolar Disorders
13. Neuro-immune Pathways in Bipolar Disorder
14. Glutamatergic Dysfunction in Bipolar Disorder
15. Neurocognitive Endophenotypes and Biomarkers in Bipolar Disorder
16. DNA Methylation in Bipolar Disorder
17. Biomarkers of Lithium Efficacy in Bipolar Disorders
18. Neuroendocrine Pathways in Bipolar Disorders
19. Intracellular Signaling in Bipolar Disorder
20. Circadian Rhythms and Bipolar Disorder
21. DNA Damage and Repair Mechanisms in Bipolar Disorder
22. Microbiome and Bipolar Disorder
23. Bipolar Disorder and Plasticity: A Key Target for New Treatments
24. Proteomic Approaches for Biomarker Discovery in Bipolar Disorder
25. Drug Development in Bipolar Disorders: New Therapeutic Targets