Biomarkers in Inflammatory Bowel Diseases (eBook, PDF)

Redaktion: Sheng Ding, Nik; De Cruz, Peter

• Format: PDF

Produktbeschreibung

Incorporates current biomarkers within practical algorithms that can be applied to clinical practice

Addresses predictive (early or ultra early) biomarkers of response to current therapeutic agents which form the backbone of medical therapy as well as prognostic biomarkers which predict disease course in inflammatory bowel disease

Presents the current state-of-the art in the research strategies that are being applied to biomarker discovery

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Produktdetails

• Verlag: Springer International Publishing
• Seitenzahl: 365
• Erscheinungstermin: 13. Mai 2019
• Englisch
• ISBN-13: 9783030114466
• Artikelnr.: 59879936

Autorenporträt

The editors are currently reviewers of major international journals. They are experts in inflammatory bowel disease (IBD) each with an interest in developing biomarkers for research development and improving patient care. The editors have also developed strong reputations within the international IBD community and have connections with each of the nominated chapter contributors. Nik Sheng Ding is a committee member for the European Crohn's and Colitis Organisation (ECCO) and a clinical lecturer at Imperial College, London. He has supervised students and is a member of the Computational Medicine division of the department of medicine. He is completing a PhD entitled "Clinical and metabolic predictors of response to anti-TNF therapy in Crohn's disease". He has authored and co-authored manuscripts, book chapters and has a major grant from ECCO to conduct his research. He is currently the principal investigator of an international study into access to IBD investigations (biomarkers) by health professionals, particularly investigating rates of usage according to health expenditure and quality of care for patients (Access to IBD investigations - ACCID). Nik has an interest in translational research with investigating the function of the microbiome through metabonomics and it's relation to outcomes in IBD. Peter De Cruz MBBS, Ph.D, FRACP Peter De Cruz is Director of the IBD service at the Austin Hospital, Senior lecturer at the University of Melbourne and Life Fellow of Clare Hall at the University of Cambridge.  Peter's doctoral research at The University of Melbourne identified the optimal strategy for preventing Crohn's disease recurrence after resectional surgery. The findings of the research have been published in the Lancet and Gastroenterology and have changed practice internationally. His postdoctoral fellowship in complex IBD and clinical nutrition was undertaken between Addenbrooke's Hospital, Cambridge and St Mark's Hospital,London. Peter's ongoing clinical research interests include identifying predictors of response to IBD therapeutics which he maintains through his translational research interest in molecular microbiology and immunology.

Inhaltsangabe

Part I: Introduction.- nflammatory bowel disease - more than meets the eye - Clinical risk factors - lessons from epidemiology.- Clinical trial design for biomarker discovery.- Database/ big data meets real world.- Patient reported outcomes.- Part II: Biomarkers - Prognostic vs Predictive.- Biomarkers for remote monitoring.- Disease modification.- Part IIV: Crohn's disease.- Luminal Crohn's disease-. Perianal CD.- Fibrosis/ strictures in CD.- Post-op Crohn's disease.- Part IV: Ulcerative colitis.- UC surveillance.- Acute severe UC.- Chronic active UC.- Pouchitis.- Refractory proctitis.- Feacal microbiota transplantation.- Primary sclerosing cholangitis.- Extraintestinal manifestations of IBD.- Part V: Specialised scenarios.- Pregnancy.- Nutrition.- TDM.- Biomarkers to quantify immune response.- Drug toxicity.- Part VI:Scientific.- Exposome and diet.- Microbiota .- Metabonomics.- Immunology.- Genomics.- Systems Biology in Biomarker research.- Part VII: Ideal tools for investigation in the future.