Biomarkers of Hip Implant Function (eBook, ePUB)

Redaktion: Swiatkowska, Ilona

• Format: ePub

Produktbeschreibung

Nearly all orthopaedic surgeons have implanted a cobalt-chromium hip, and most general practitioners have at least one patient with a cobalt-chromium prosthesis on their books. The recent worldwide controversy surrounding metal-on-metal bearings - and increasing concern over the use of metallic biomaterials in general - means that advice on how to manage patients with metal implants is of great interest to these professionals. Specifically, they want to know if there are any diagnostic tests that could be performed to gain clues about implant performance and the risk of local or systemic toxicity. Biomarkers of Hip Implant Function aims to bring together all established and promising new biomarkers and critically evaluate their clinical usefulness. Researchers will benefit from an updated, comprehensive view of the topic to identify underexplored areas. Orthopaedic surgeons and general practitioners will use the book to monitor implant performance and manage their patients. The work may also benefit engineers and joint implant manufacturers by guiding improvements in implant design, and be of interest to regulators and policymakers to inform guidelines on the follow-up of hip implant recipients. - Covers all established and candidate biomarkers of hip implant wear, periprosthetic infection, and toxicity - Summarises recent research into blood titanium levels associated with well-functioning and malfunctioning hip implants to aid implant revision decisions - Reviews over 50 cases of suspected systemic cobalt toxicity to raise awareness of its symptoms and clinical presentation, and guide investigations and treatment decisions

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Produktdetails

• Verlag: Elsevier Science & Techn.
• Seitenzahl: 292
• Erscheinungstermin: 10. Januar 2023
• Englisch
• ISBN-13: 9780128217429
• Artikelnr.: 67274286

Inhaltsangabe

Part I: Foundational information
1. Introduction to hip implants and biomarker testing
Ilona Swiatkowska, Shiraz A. Sabah, Laura-Maria Horga and Alister J. Hart
2. Degradation of metal hip implants
Andrew R. Beadling, Anne Neville and Michael G. Bryant
3. Implant metals and their potential toxicity
Ilona Swiatkowska

Part II: Assessing hip implant function and risk of local and systemic adverse reactions
4. Markers of hip implant degradation: analytical considerations and clinical interpretation
Pascal-Andre Vendittoli, Angela Styhler and Ilona Swiatkowska
5. Biomarkers of compromised implant fixation
Reshid Berber, Benjamin Bloch, Peter James and Andrew Manktelow
6. Biomarkers of periprosthetic joint infection
Marc-Olivier Kiss and Vincent Masse
7. Hip implants and systemic cobalt toxicity: a comprehensive review with case studies
Ilona Swiatkowska, Obakanyin J. Akinfosile, Ravindra V. Badhe, Mark Barba, Mathew T. Mathew and Divya Bijukumar

Part III: Translational effect of biomarker research on clinical practice
8. Clinical guidelines on the use of biomarkers for surveillance of hip replacements
Harry Hothi, Reshid Berber, Shiraz A. Sabah and Alister J. Hart

Rezensionen

*4 stars* "...details the recognized and potential biomarkers of hip implant wear, periprosthetic joint infection, and toxicity. It begins with basic definitions and descriptions, follows with complex interactions, and concludes with future directions. The purpose of the book is to assemble the established biomarkers of hip implant function and critically evaluate their clinical utility . Researchers will be able to identify underexplored areas and engineers can use the database for improvement in implant design. ...[D]etails the clinical implications and treatment of local and systemic effects of wear debris [and] includes excellent comprehensive references . [An] excellent, focused book on a very important topic, [A] mandatory addition to medical libraries frequented by the target audience of readers who still reference print books." --©Doody s Review Service, 2023, Samuel J. Chmell, MD (University of Illinois at Chicago College of Medicine)