Biopharmaceutical Drug Design and Development (eBook, PDF)

Redaktion: Wu-Pong, Susanna; Rojanasakul, Yon

• Format: PDF

Produktbeschreibung

Biopharmaceutical Drug Design and Development, Second Edition, furthers the widely successful first edition, published in 1999. This new, expanded edition investigates the dozens of new biopharmaceutical drugs that have become available since that time. Among the drugs discussed are ones in the categories of monoclonal antibodies for in-vivo use, cytokines, growth factors, enzymes, immunomodulators, thrombolytics, and immonotherapies including vaccines. Additionally, the volume examines new and emerging technologies, such as bioinformatics, DNA microarrays, transgenics, therapeutic gene delivery, stem cells, nucleic acid-based therapeutics, and macromolecular drug delivery. Authors also study pharmacogenetics in the clinic and changes in biologic drug approval at the FDA. Biopharmaceutical Drug Design and Development, Second Edition, is a worthy sequel to a discussion on the dynamic, exciting field of biotechnology.

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Produktdetails

• Verlag: Humana Press
• Seitenzahl: 375
• Erscheinungstermin: 11. Januar 2010
• Englisch
• ISBN-13: 9781597455329
• Artikelnr.: 37348542

Autorenporträt

Susanna Wu-Pong, Virginia Commonwealth University, Richmond, VA / Yon Rojanasakul, West Virginia University, Morgantown, WV, USA

Inhaltsangabe

Biotechnology: 2008 and Beyond.- The Human Genome Project and Drug Development.- The Use of Bioinformatics and Chemogenomics in Drug Discovery.- DNA Microarrays in Drug Discovery and Development.- Microarray Technology Using Proteins, Cells, and Tissues.- Pharmacogenetic Issues in Biopharmaceutical Drug Development.- Development and Applications of Transgenics in Biotechnology and Medicine.- Viral, Nonviral, and Physical Methods for Gene Delivery.- Stem Cell Technology and Drug Development.- Small Nucleic Acid-Based Drugs: Successes and Pitfalls.- Therapeutic Strategies Targeting the Innate Antiviral Immune Response.- Pharmacogenetics in the Clinic.- Molecular Modeling: Considerations for the Design of Pharmaceuticals and Biopharmaceuticals.- Macromolecular Drug Delivery.- Changes in Biologic Drug Approval at FDA.- Follow-On Protein Products: The Age of Biogenerics?.

Rezensionen

From the reviews of the second edition:

"The book comprises 16 chapters written by 24 authors from academic and industrial laboratories in the U.S. The book is suitable for a wide audience of industrial and academic pharmaceutical scientists interested in a broad introduction to biopharmaceutical technology within the context of drug design and development. ... Overall, the book is well written with an excellent nine-page index. The chapters are generally well illustrated. ... it would be a valuable addition to industrial and academic libraries." (Aliasger K. Salem, Journal of Medicinal Chemistry, Vol. 51 (19), 2008)

"This book is an update of the first edition of Biopharmaceutical Drug Development ... . this book is dedicated to quite detailed discussion of the impact the various 'omic' technologies have had on drug discovery and design. ... Overall, this is quite a useful reference book for toxicologists working in the biopharmaceutical sector, particularly if they are still getting to grips with the various 'omics' technologies and areas such stem cell therapy and gene silencing." (Peter Ryle, British Toxicological Society Newsletter, June-August, 2009)