Bone and Osteoarthritis (eBook, PDF)

Redaktion: Bronner, Felix; Farach-Carson, Mary C.

• Format: PDF

Produktbeschreibung

Recently, there has been renewed interest in the role played by bone in the development of osteoarthritis, including targeting bone as a potential therapeutic approach. The molecular and cellular approaches toward the relationship of joint and bone problems distinguish this from other books on osteoarthritis or skeletal medicine. Emphasis on genetics and newer viewpoints and approaches, gives a wider viewpoint and may make possible novel approaches to solving a clinical problem. Topics discussed include the role of bone in osteoarthritis, ranging from basic cell and molecular biology to genetics and biomechanics. The book will enable the novice to become oriented with the subject and allow the practitioner to update knowledge.

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Produktdetails

• Verlag: Springer London
• Seitenzahl: 218
• Erscheinungstermin: 26. September 2007
• Englisch
• ISBN-13: 9781846287015
• Artikelnr.: 37356388

Autorenporträt

Series Editors of Topics in Bone Biology are: Professors Felix Bronner, PhD - University of Connecticut Health Center, Farmington, CT, USA, and Dr Mary C. Farach-Carson, PhD - the Department of Biology, University of Delaware, Newark, DE, USA. In this fourth volume, the Series Editors are joined by a co-editor with special expertise in the volume topic, Dr Richard F. Loeser, MD, the Robert S. Katz, MD - Joan and Paul Rubschlager Presidential Professor of Osteoarthritis Research in the Department of Internal Medicine, Section of Rheumatology with a conjoint appointment in the Department of Biochemistry, Rush University, Chicago, IL, USA.

Inhaltsangabe

Overview chapter on the pathogenesis of OA - The role of bone in the development of OA - Bone derived factors (cytokines and growth factors) and their influence on cartilage - The role of the synovium in OA - The cartilage-bone interface in OA/calcified cartilage zone - Cartilage matrix destruction: MMPs and TIMPs - Anabolic mediators of cartilage healing - Role of chondrocyte hypertrophy in OA - The genetics of OA - Animal Models of OA - Biomechanical Factors in OA - Treatment: Novel Pharmaceuticals.