Carbonic Anhydrases (eBook, ePUB)

Biochemistry and Pharmacology of an Evergreen Pharmaceutical Target
Redaktion: Supuran, Claudiu T.; Nocentini, Alessio

• Format: ePub

Produktbeschreibung

Carbonic Anhydrases provides an interdisciplinary review of the burgeoning carbonic anhydrase (CA) research area, spanning from CAs classification (biochemical and structural features) to drug design and pharmacology of CA inhibitors and activators, finally touching on the biotechnological applications of these metalloenzymes. The book adopts a clear step-by-step approach and introduction to this intricate and highly interdisciplinary field. A diverse range of chapters from international experts speak to CA classification and distribution, the mechanisms of action and drug design of inhibitors and activators, the druggability of the various isoforms in the treatment of a multitude of diseases, and threats to human health.

Carbonic Anhydrases provides biology, biochemistry, and medicinal chemistry students and researchers a thorough discussion and update on the evergreen and expanding research area of CAs.

• Offers a full overview of CAs' biochemical and structural features, as well as drug design and pharmacology of inhibitors and activators
• Provides a thorough update on the newly identified isoforms, modulating chemotypes, and innovative biomedical applications
• Describes the current biotechnological applications of CAs, including processes for CO2 capture
• Features chapter contributions from international leaders in CA biology, medicinal chemistry, and pharmacology

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Produktdetails

• Verlag: Elsevier Science & Techn.
• Seitenzahl: 560
• Erscheinungstermin: 17. Juli 2019
• Englisch
• ISBN-13: 9780128167458
• Artikelnr.: 68434221

Inhaltsangabe

1. Carbonic Anhydrases: An Overview 2.
-Carbonic Anhydrases 3. ß-Carbonic Anhydrases 4.
-Carbonic Anhydrases 5.
-Carbonic Anhydrases 6.
-Carbonic Anhydrases 7.
and
-Carbonic Anhydrases 8. Human Carbonic Anhydrases: Tissue Distribution, Physiological Role and Druggability 9. Mechanisms of Action of Carbonic Anhydrase Inhibitors: Zinc Binders 10. Mechanisms of Action of Carbonic Anhydrase Inhibitors: Compounds That Anchor to The Zinc-Bound Nucleophile 11. Mechanisms of Action of Carbonic Anhydrase Inhibitors: Compounds Occluding the Entrance of The Active Site 12. Mechanisms of Action of Carbonic Anhydrase Inhibitors: Compounds That Bind "Out of The Binding Site? And Compounds with An Unknown Mechanism of Action 13. Carbonic Anhydrase Inhibitors as Ophthalmologic Drugs for The Treatment of Glaucoma 14. Carbonic Anhydrase Inhibitors as Diuretics 15. Carbonic Anhydrase Inhibitors for The Treatment of Epilepsy and Obesity 16. Carbonic Anhydrase Inhibitors for The Treatment of Tumors: Therapeutic, Immunologic, And Diagnostic Tools Targeting Isoforms IX And XII 17. Carbonic Anhydrase Inhibitors for The Treatment of Neuropathic Pain and Arthritis 18. Carbonic Anhydrases from Pathogens: Bacterial Cas And Their Inhibitors as Potential Anti-Infectives 19. Carbonic Anhydrases from Pathogens: Fungal Cas And Their Inhibitors as Potential Antifungal Agents 20. Carbonic Anhydrases from Pathogens: Protozoan Cas And Related Inhibitors as Potential Anti-Protozoal Agents 21. Carbonic Anhydrase Activators and Their Potential in The Pharmaceutical Field 22. Biotechnological Applications of Carbonic Anhydrases from Extremophiles 23. CO2 Capture by Engineered Mammalian Carbonic Anhydrases