Cellular Senescence and Tumor Suppression (eBook, PDF)

Redaktion: Adams, Peter D.; Sedivy, John M.

• Format: PDF

Produktbeschreibung

As cells mature they naturally stop dividing and enter a period called senescence. But cellular senescence can also be induced prematurely by certain oncogenes involved in cancer development. Cellular senescence, a growth-arrest program that limits the lifespan of mammalian cells and prevents unlimited cell proliferation, is attracting considerable interest because of its links to tumor suppression.

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Produktdetails

• Verlag: Springer US
• Seitenzahl: 272
• Erscheinungstermin: 23. Januar 2010
• Englisch
• ISBN-13: 9781441910752
• Artikelnr.: 37352676

Inhaltsangabe

Senescence signals.- Telomere Biology and Biochemistry.- Role of RecQ Helicases in Nuclear DNA Repair and Telomere Maintenance.- Oncogene-Induced Senescence (OIS) as a Cellular Response to Oncogenic Stresses.- Stress-Induced Senescence.- The senescent phenotype.- The Secretome of Senescent Cells.- Chromatin Structure in Senescent Cells.- A Comparison of Senescence in Mouse and Human Cells.- The physiological consequences of senescence.- Replicative Senescence as an Intrinsic Tumor-Suppressor Mechanism.- Telomere Dysfunction and Senescence in Stem Cell and Tissues Aging.- Mining Cellular Senescence for Drug Targets.