Centromeres and Kinetochores (eBook, PDF)

Discovering the Molecular Mechanisms Underlying Chromosome Inheritance
Redaktion: Black, Ben E.

• Format: PDF

Produktbeschreibung

Presents the latest advances concerning the regulation of chromosome segregation during cell division

Covers state-of-the-art techniques employed in the field

Incorporates a wealth of different model systems and species

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Produktdetails

• Verlag: Springer International Publishing
• Seitenzahl: 554
• Erscheinungstermin: 23. August 2017
• Englisch
• ISBN-13: 9783319585925
• Artikelnr.: 53062095

Inhaltsangabe

Preface.- Use of Mass Spectrometry to Study the Centromere and Kinetochore.- Critical Foundation of the Kinetochore: the Constitutive Centromere Associated Network (CCAN).- The Power of Xenopus Egg Extract for Reconstitution of Centromere and Kinetochore Function.- Centrochromatin of Fungi.- Evolutionary Lessons from Species with Unique Kinetochores.-Quantitative Microscopy Reveals Centromeric Chromatin Stability, Size, and Cell Cycle Mechanisms to Maintain Centromere Homeostasis.- Orchestrating the Specific Assembly of Centromeric Nucleosomes.- Artificial Chromosomes and Strategies to Initiate Epigenetic Centromere Establishment.- Post-translational Modifications of Centromeric Chromatin.- Centromere Silencing Mechanisms.- Centromere Transcription: Means and Motive.- The Promises and Challenges of Genomic Studies of Human Centromeres.- DNA Sequences in Centromere Formation and Function.- The Unique DNA Sequences Underlying Equine Centromeres.- Centromere Dynamics in Male and

Female Germ Cells.- Cell Biology of Cheating-Transmission of Centromeres and Other Selfish Elements Through Asymmetric Meiosis.- Biophysics of Microtubule End Coupling at the Kinetochore.- Molecular Mechanisms of Spindle Assembly Checkpoint Activation and Silencing.- A Kinase-Phosphatase Network That Regulates Kinetochore-Microtubule Attachments and the SAC.- Centromeric Cohesion: Molecular Glue and Much More.- Centromere Structure and Function.- The Role of Centromere Defects in Cancer.