Chemical and Structural Approaches to Rational Drug Design (eBook, PDF)

Redaktion: Weiner, David B.; Williams, William V.

• Format: PDF

Produktbeschreibung

This book is the first to provide both a broad overview of the current methodologies being applied to drug design and in-depth analyses of progress in specific fields. It details state-of-the-art approaches to pharmaceutical development currently used by some of the world's foremost laboratories. The book features contributors from a variety of fields, new techniques, previously unpublished data, and extensive reference lists.

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Produktdetails

• Verlag: Taylor & Francis eBooks
• Seitenzahl: 288
• Erscheinungstermin: 17. Dezember 2020
• Englisch
• ISBN-13: 9781000099058
• Artikelnr.: 60736675

Autorenporträt

Weiner\, David B.; Williams\, William V.

Inhaltsangabe

Section I: Chemical Approaches to Rational Drug Design 1. Design, Synthesis
and Antitumor Activity of an Inhibitor of Ribonucleotide Reductase 2. The
Development of Human Immunodeficiency Virus Type 1 Reverse Transcriptase
Inhibitors 3. The Development of Potent Angiotensin II Receptor Antagonists
Using a Novel Peptide Pharmacophore Model 4. Endothelin Structure and
Development of Receptor Antagonists 5. Molecular Targeting Chemistry in
Rational Drug Design Section II: Structural Approaches to Rational Drug
Design 6. The Role of X-Ray Crystallography in Structure-Based Rational
Drug Design 7. Biocomputational Approaches to Protein-Based Drug Design 8.
Architecture and Design of Zinc Protein-Ligand Complexes 9. Design of
Immunomodulatory Peptides Based on Active Site Structures