Computational and Experimental Studies in Alzheimer's Disease (eBook, PDF)

Redaktion: Bhattacharya, Kunal; Bhattacharjee, Atanu

• Format: PDF

Produktbeschreibung

This reference book compiles the recent advances in computational and experimental modelling to screen and manage Alzheimer's disease. It covers basic etiopathology and various in vitro and in vivo strategies of disease intervention. The book discusses how computer-aided drug design approaches reduce costs and increase biological test efficiency. It reviews the screening for anti-Alzheimer drugs and biomarker analysis of disease inhibitors. The book also explores mechanistic aspects of neurodegeneration and the use of natural products as therapeutics for Alzheimer's disease.

Key features:

• Elaborates on the computational modelling of protein target inhibitors as anti-Alzheimer's agents
• Explains the role of phytomolecules and natural products in Alzheimer's therapy
• Reviews preclinical ways to assess drugs focusing on Alzheimer's disease
• Covers biomarker analysis for Alzheimer's disease
• Discusses the onset and progression of Alzheimer's disease

The book is meant for professionals, researchers, and students of neuroscience, psychology, and computational neurosciences.

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Produktdetails

• Verlag: Taylor & Francis eBooks
• Seitenzahl: 210
• Erscheinungstermin: 29. März 2024
• Englisch
• ISBN-13: 9781003857341
• Artikelnr.: 69981421

Autorenporträt

Kunal Bhattacharya is currently working as assistant professor in Pratiksha Institute of Pharmaceutical Sciences, Assam, India. His area of specialization includes Computer aided drug design, Bioinformatics and Analytical Chemistry. He obtained his M.Pharm in Pharmaceutical Chemistry from Nitte University, Mangalore, India. He is currently pursuing his PhD in pharmaceutical sciences in neurodegenerative diseases from The Assam Royal Global University, Assam, India. Atanu Bhattacharjee is currently working as a professor at School of Pharmacy, The Assam Royal Global University, Assam, India. He is considered as pioneer in the field of pharmacognosy and phytochemistry. Dr. Bhattacharjee achieved his Ph.D in Pharmaceutical Sciences in the areas of phytochemistry and neuro-pharmacology from Nitte University, Mangalore, India. He worked extensively on various in silico, in vitro and in vivo experiments to encounter neuro-degenerative disorders like Alzheimer's disease with folklore medicine from the Indian diaspora and to determine safety profiles and standardize medicinal plants.

Inhaltsangabe

Chapter 1: Alzheimer's Disease: Epidemiology
Neuropathology
and Neurochemistry Raushan Kumar Chaudhary
Uday Venkat Mateti
Pukar Khanal
Kala Bahadur Rawal
Praneetha Jain
Vishal S Patil
Amit Kumar Shrivastava and B M Patil Chapter 2: Preclinical Approach: In vivo and In vitro Methods for Evaluation of Anti-Alzheimer's Drugs Nilutpal Sharma Bora
Bhargab Jyoti Sahariah
Chanam Melody Devi and Banshongdor H. Mawlieh Chapter 3: Computational Insights into the Applications of Plant-Based Therapies in Alzheimer's Disease Dibyajyoti Das
Satyendra Deka
Biswajit Devanath
Aparoop Das
Nongmaithem Randhoni Chanu and Ramen Kalita Chapter 4: Advances in Applying Computer-Aided Drug Design for Alzheimer's Disease Biswajit Devanath
Satyendra Deka
Dibyajyoti Das
Hans Raj Bhat
Nongmaithem Randhoni Chanu and Kunal Bhattacharya Chapter 5: Biomarkers Analysis for Alzheimer's Disease Shraddha M. Jadhav and Karan Kumar Chapter 6: Mechanistic Aspects of Neurodegeneration in Alzheimer's Disease and the Role of Phytochemicals Trideep Saikia
Tutumoni Kalita
Bhanu P Sahu
Prakash Rajak
Bhargab Deka and Alakesh Bharali Chapter 7: Computational Modelling of BACE-1
AChE
and Phosphodiesterase Inhibitors as Anti-Alzheimer's Agents Vishal S Patil
Jagadeesh Dodakallanavar
Pukar Khanal
B M Patil
Raushan K Chaudhary
Amit Kumar Shrivastava
Nongmaithem Randhoni Chanu
Darasaguppe R. Harish and Uday Venkat Mateti Chapter 8: Therapeutic Application of Natural Products in Alzheimer's Disease Using Computational Methods Muhammad Aqib Shabbir
Muhammad Naveed
Maleeha Manzoor
Hafiz Muhammad Hurraira
Noor-ul-Ain and Fatima Zaidi Chapter 9: Analysis of Potential Alzheimer's Disease Inhibitors Based on Computational Modelling with Multiple Targets Ankita Dubey
Vrishti M Thakur
Raja Chakraborty
G.N. Darwhekar
Rupesh Kushwah and Rakhi Khabiya Chapter 10: Virtual Screening: Pioneering the Future of Drug Discovery in Alzheimer's Disease N. Yellasubbaiah
B. Sivakumar and B. Nagasudha Index