Computational Protein-Protein Interactions (eBook, ePUB)

Redaktion: Nussinov, Ruth; Schreiber, Gideon

• Format: ePub

Produktbeschreibung

Often considered the workhorse of the cellular machinery, proteins are responsible for functions ranging from molecular motors to signaling. The broad recognition of their involvement in all cellular processes has led to focused efforts to predict their functions from sequences, and if available, from their structures. An overview of current resear

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Produktdetails

• Verlag: Taylor & Francis eBooks
• Seitenzahl: 344
• Erscheinungstermin: 26. Juni 2009
• Englisch
• ISBN-13: 9781040206553
• Artikelnr.: 72538592

Autorenporträt

Ruth Nussinov, Gideon Schreiber

Inhaltsangabe

Computational design of protein-protein interactions. Molecular Mimicry and
Competitive Recruitment. Intrinsically unstructured proteins. The molecular
architecture of protein-protein binding sites. Characteristic of
protein-protein recognition. Protein-Protein Docking. Identification of hot
spots within druggable binding regions. Hot-spot mimicry of ac cytokine
receptor. Chaperone-related immune dysfunction. Recognition proteins of the
innate immune system. Epitope mapping using combinatorial phage-display
libraries. Identification of conserved protein complexes based on a model
of protein network evolution. Interaction sites identified from sequences.
Thermophilic Protein Complex Stabilized by Topological Interlinked. Protein
interface recognition for structural proteomics. Strategies to search and
design stabilizers of protein-protein interactions. Dynamics and allostery
in protein-protein interactions.