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Corneal Cross-Linking, Second Edition represents an innovative approach to treating primary acquired and secondary induced ectatic disorders. In addition, corneal cross-linking (CXL) has promising applications as an alternative in the treatment of corneal infectious and non-infectious melting, as well as conditions such as Fuchs' endothelial dystrophy. The new and expanded Second Edition of Corneal Cross-Linking by Drs. Farhad Hafezi and J. Bradley Randleman will provide a concise yet comprehensive summary of the CXL process, including the basic science foundations, treatment protocols…mehr
Corneal Cross-Linking, Second Edition represents an innovative approach to treating primary acquired and secondary induced ectatic disorders. In addition, corneal cross-linking (CXL) has promising applications as an alternative in the treatment of corneal infectious and non-infectious melting, as well as conditions such as Fuchs' endothelial dystrophy.
The new and expanded Second Edition of Corneal Cross-Linking by Drs. Farhad Hafezi and J. Bradley Randleman will provide a concise yet comprehensive summary of the CXL process, including the basic science foundations, treatment protocols and outcomes, recognition and management of potential complications, and modification of standard protocol for special circumstances.
Given all the changes in this rapidly progressing field, many brief topics from the first edition have now grown into full chapters or sections. These include expanded sections on alternative treatment protocols, corneal imaging and biomechanics, combing cross-linking with other refractive treatments, and a section devoted specifically to the most highly debated controversies in the field today.
With each chapter being fully updated plus including over twenty new chapters that covers the latest advances and future directions, Corneal Cross-Linking, Second Edition represents the cutting-edge of CXL research and clinical practice.
"Since the publication of the first edition of this book in 2013, our knowledge of corneal cross-linking has again significantly increased, both scientifically and clinically. Today, concise recommendations (guidelines for cross-linking) help the clinician to select the patients, make decisions, and provide optimal treatment" -Eberhard Spoerl, PhD and Theo Seiler, MD, PhD
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Autorenporträt
Farhad Hafezi, MD, PhD, was born in 1967 and grew up in Fribourg, Switzerland. He studied medicine in Fribourg and Berne.Farhad Hafezi fluently speaks German (mother tongue), English, French, Polish, and Farsi. He is married to Nikki Hafezi and has three daughters, Leilah Alina (2008), Lilian Malaya (2010), and Lola Alexandra (2016). Professor Hafezi's clinical focus are the cornea and complication management after complicated refractive laser surgery. Being part of the team around Theo Seiler that translated cross-linking from experimental research into the clinical application, he was instrumental in implementing corneal cross-linking technology in ophthalmology. From 2010 to 2014, Farhad Hafezi was Professor and Chairman of the Department of Ophthalmology of the Geneva University Hospitals, Geneva, Switzerland. Currently, Dr. Hafezi holds the following positions: Professor at the Faculty of Medicine, University of Geneva, Switzerland; Clinical Professor of Ophthalmology, Department of Ophthalmology USC Los Angeles, USA; Medical Director, The ELZA Institute, Zürich, Switzerland; Research Group Leader, Center for Applied Biotechnology and Molecular Medicine (CABMM), University of Zürich, Switzerland; and Visiting Professor, Faculty of Medicine, University of Wenzhou, China. As of March 2017, Professor Hafezi has published more than 160 scientific articles, his scientific work has been cited more than 5700 times, his total impact factor is 510, and his h-index is 39. He is an Associate Editor for the Journal of Refractive Surgery and is on the Editorial Boards of TVST, the International Journal of Keratoconus and Ectatic Corneal Disease, Eye and Vision and the Iranian Journal of Ophthalmology. Professor Hafezi is also a member of the Advisory Board of "Global ONE," the educational network of the American Academy of Ophthalmology (AAO). Professor Hafezi has received 22 national and international awards and distinctions, both for his scientific work and for the development of new technologies (innovation awards). Awards include, among others, the ARVO Foundation/Carl Camras Translational Research Award (USA) 2014, as well as the highest distinctions in ophthalmology from Switzerland and Belgium. In 2014, Professor Hafezi was voted by peers onto the "PowerList," a list of the 100 most influential international personalities in ophthalmology. In April 2016, he was again voted onto the PowerList. For more information, please visit: https://en.wikipedia.org/wiki/Farhad_Hafezi or http://www.elza-institute.com J. Bradley Randleman, MD, is Professor of Ophthalmology at the Keck School of Medicine of USC and Director of the Cornea & Refractive Surgery Service at the USC Roski Eye Institute in Los Angeles, California. A widely respected cornea specialist, his areas of expertise include: corneal and intraocular refractive surgical procedures including LASIK and premium laser-assisted cataract and IOL surgery, complicated cataract surgery, and the management of corneal ectatic disorders. His primary research focuses on identification and management of corneal ectatic diseases including keratoconus and postoperative ectasia after LASIK, and the avoidance, diagnosis, and management of refractive surgical complications. Dr. Randleman received his BA degree from Columbia College at Columbia University in New York City, his M.D. degree from Texas Tech University School of Medicine in Lubbock, Texas, where he was elected to the Alpha Omega Alpha medical honor society in his junior year, followed by his Ophthalmology residency at Emory University in Atlanta, Georgia. Dr. Randleman joined the Emory faculty and served as Assistant Residency Director for two years while also completing a fellowship in Cornea/External Disease, and Refractive Surgery at Emory University. He served as Director of the Emory Corneal Fellowship program until taking over as Director of the Cornea Service. Dr. Randleman has been awarded the Claus Dohlman Fellow Award, the inaugural Binkhorst Young Ophthalmologist Award from the American Society of Cataract and Refractive Surgery, the Kritzinger Memorial Award, the Inaugural ISRS Recognition Award, the Secretariat Award, Achievement Award, and Senior Achievement Award from the American Academy of Ophthalmology. Dr. Randleman has served as Editor-in-Chief for the Journal of Refractive Surgery since 2011. He has authored more than 120 peer-reviewed publications in leading ophthalmology journals in addition to 30 book chapters on refractive surgery evaluation, corneal cross-linking, and management of complications with IOLs, and has authored two additional textbooks, Refractive Surgery: An Interactive Case-Based Approach (2014), and Intraocular Lens Surgery: Selection, Complications, and Complex Cases.
Inhaltsangabe
Dedication About the EditorsAbout the Associate Editor Contributing Authors Foreword by Eberhard Spoerl PhD and Theo Seiler MD PhDIntroduction Section I Basic Principles of Corneal Biomechanics and Corneal Cross-Linking Chapter 1 History of Corneal Cross-Linking Eberhard Spoerl PhD and Frederik Raiskup MD PhD FEBO Chapter 2 Introduction to Corneal Biomechanics William J. Dupps Jr MD PhD Chapter 3 Fundamental Principles of Corneal Cross-Linking Gregor Wollensak MD Chapter 4 Riboflavin Ultraviolet Light and the Photochemical ReactionArie L. Marcovich MD PhD and Alexander Brandis PhD Chapter 5 The Role of Oxygen in Corneal Cross-Linking Olivier Richoz MD PhD; Sabine Kling PhD; and Farhad Hafezi MD PhD Chapter 6 Cross-Linking Initiated by Other Chromophores and by Multiphoton Excitation Irene Kochevar PhD Chapter 7 Corneal Cross-Linking Safety Considerations Christina Giannikas Starcic MD; Leejee H. Suh MD; and Stephen L. Trokel MD Chapter 8 Molecular Aspects of Corneal Cross-LinkingRohit Shetty FRCS PhD; Natasha Kishore Pahuja DOMS; and Harsha Nagaraja MS FCE Chapter 9 Evaluation and Diagnosis of Keratoconus and Pellucid Marginal Degeneration Marcony R. Santhiago MD PhD; Yaron S. Rabinowitz MD; and J. Bradley Randleman MD Chapter 10 Evaluation and Diagnosis of Postoperative Corneal Ectasia J. Bradley Randleman MD; Maria A. Woodward MD MS; and Marcony R. Santhiago MD PhD Section II Corneal Cross-Linking for Corneal Ectasias Chapter 11 Corneal Cross-Linking for Progressive KeratoconusTobias Koller MD; Stefan Seiler MD; and Theo Seiler MD PhD Chapter 12 Corneal Cross-Linking for Postoperative Corneal EctasiaDavid Tabibian MD and Farhad Hafezi MD PhD Chapter 13 Corneal Cross-Linking for Pellucid Marginal Degeneration Leopoldo Spadea MD and Roberto Secondi MD Section III Corneal Cross-Linking Protocols and Complication Management Chapter 14 The Standard Protocol and Its Parameters Maria A. Woodward MD MS; David L. DeMill MD; Francis W. Price Jr MD; and Marianne O. Price PhD MBA Chapter 15 Corneal Cross-Linking Using Accelerated Protocols George D. Kymionis MD PhD; Konstantinos I. Tsoulnaras MD; and Chrysanthi Koutsandrea MD PhD Chapter 16 Epithelium-On Protocols: Conceptual/Basic Science Eberhard Spoerl PhD and Suphi Taneri MD Chapter 17 Transepithelial Corneal Cross-Linking in Progressive Keratoconus Frederik Raiskup MD PhD FEBO Chapter 18 Corneal Cross-Linking With IontophoresisPaolo Vinciguerra MD; Riccardo Vinciguerra MD; Fabrizio Camesasca MD; Vito Romano MD; and Pietro Rosetta MD Chapter 19 Cross-Linking Protocols in Thin Corneas Soosan Jacob MS FRCS DNB and Amar Agarwal MS FRCS FRCOphth Chapter 20 Pediatric Corneal Cross-Linking Joseph Frucht-Pery MD and Denise Wajnsztajn MD Chapter 21 Corneal Cross-Linking Complications and Management Karolinne Maia Rocha MD PhD; Koray Gümü? MD FEBOphth; and J. Bradley Randleman MD Section IV Corneal Cross-Linking Imaging and Diagnostic Evaluations Chapter 22 Measuring the Efficacy of Corneal Cross-Linking Using Advanced Corneal Biomechanical Diagnostic Modalities Renato Ambrósio Jr MD PhD; Marcella Q. Salomão MD; and Cynthia Roberts PhD Chapter 23 Measuring the Efficacy of Cross-Linking: Clinical Metrics J. Bradley Randleman MD and Praneetha Thulasi MD Chapter 24 Measuring Corneal Cross-Linking Efficacy: Biomechanical Measurement Approach Giuliano Scarcelli; Seok Hyun Yun; and J. Bradley Randleman MD Chapter 25 Confocal Microscopy in Corneal Cross-LinkingCosimo Mazzotta MD PhD and Luigi Fontana MD PhD Chapter 26 Optical Coherence Tomography Use in Corneal Cross-Linking Sumitra S. Khandelwal MD and J. Bradley Randleman MD Chapter 27 Epithelial Remodeling After Corneal Cross-Linking Karolinne Maia Rocha MD PhD and Sudeep Dilip Sunthankar MD Section V Cross-Linking Plus: Combination Procedures Chapter 28 Corneal Cross-Linking in Combination With Transepithelial Phototherapeutic Keratectomy: Cretan ProtocolGeorge D. Kymionis MD PhD; Michael A. Grentzelos MD; and Chrysanthi Koutsandrea MD PhD Chapter 29 Corneal Cross-Linking in Combination With Surface Ablation: Athens Protocol Anastasios John Kanellopoulos MD and George Asimellis PhD Chapter 30 Corneal Cross-Linking in Combination With Intracorneal Ring SegmentAylin K?l?ç MD and David Touboul MD Chapter 31 Corneal Cross-Linking in Combination With Phakic Intraocular Lenses Jose L. Güell MD PhD; Merce Morral MD PhD; Emilio J. Segovia MD; Oscar Gris MD PhD; Daniel Elies MD; and Felicidad Manero MD Chapter 32 Corneal Cross-Linking: Combined Treatment Options Efekan Coskunseven MD and Onurcan Sahin MSc Chapter 33 Corneal Cross-Linking as a Primary Refractive ProcedureGeorge D. Kymionis MD PhD; Dimitra M. Portaliou MD PhD FEBO; Michael A. Grentzelos MD; and Chrysanthi Koutsandrea MD PhD Section VI Cross-Linking for Infectious Keratitis: PACK-CXL Chapter 34 PACK-CXL Jes Mortensen MD and Karim Makdoumi MD PhD Chapter 35 PACK-CXL for Viral Keratitis and Acanthamoeba Keratitis Francis W. Price Jr MD and Marianne O. Price PhD MBA Section VII Other Uses for Cross-Linking Chapter 36 Corneal Cross-Linking for Corneal Stromal Edema Niels Ehlers MD PhD and Jesper Hjortdal MD PhD Chapter 37 Sclera Cross-Linking Brendan Geraghty BEng(Hons) MSc PhD and Ahmed Elsheikh BEng(Hon) MSc PhD Section VIII Current Controversies and Perspectives Chapter 38 Epithelium-On Treatments In Favor Steven E. Wilson MD and Andre A.M. Torricelli MD PhD Opposed Aldo Caporossi MD PhD FRCS; Antonio Villano MD; Stefano Baiocchi MD PhD; and Orsola Caporossi MD PhD Chapter 39 Corneal Cross-Linking Can Impact Limbal Stem Cells In Favor Johnny E. Moore FRCOphth PhD; David Schiroli PhD; and C.B. Tara Moore PhD Opposed Farhad Hafezi MD PhD and Sabine Kling PhD Chapter 40 Performing Corneal Cross-Linking After Definitive Signs of Ectasia Progression Are Detected Renato Ambrósio Jr MD PhD; Rosane de Oliveira Corrêa MD; and Rozalia Litewski Beildeck MD Chapter 41 Prophylactic Cross-Linking Combined With LASIK In FavorAnastasios John Kanellopoulos MD and George Asimellis PhD Opposed Theo Seiler MD PhD Chapter 42 Summary of Commercially Available Corneal Cross-Linking Units George O. Waring IV MD FACS; Susannah L. Brown MD; and Frederik Raiskup MD PhD FEBO Financial Disclosures Index
Dedication About the EditorsAbout the Associate Editor Contributing Authors Foreword by Eberhard Spoerl PhD and Theo Seiler MD PhDIntroduction Section I Basic Principles of Corneal Biomechanics and Corneal Cross-Linking Chapter 1 History of Corneal Cross-Linking Eberhard Spoerl PhD and Frederik Raiskup MD PhD FEBO Chapter 2 Introduction to Corneal Biomechanics William J. Dupps Jr MD PhD Chapter 3 Fundamental Principles of Corneal Cross-Linking Gregor Wollensak MD Chapter 4 Riboflavin Ultraviolet Light and the Photochemical ReactionArie L. Marcovich MD PhD and Alexander Brandis PhD Chapter 5 The Role of Oxygen in Corneal Cross-Linking Olivier Richoz MD PhD; Sabine Kling PhD; and Farhad Hafezi MD PhD Chapter 6 Cross-Linking Initiated by Other Chromophores and by Multiphoton Excitation Irene Kochevar PhD Chapter 7 Corneal Cross-Linking Safety Considerations Christina Giannikas Starcic MD; Leejee H. Suh MD; and Stephen L. Trokel MD Chapter 8 Molecular Aspects of Corneal Cross-LinkingRohit Shetty FRCS PhD; Natasha Kishore Pahuja DOMS; and Harsha Nagaraja MS FCE Chapter 9 Evaluation and Diagnosis of Keratoconus and Pellucid Marginal Degeneration Marcony R. Santhiago MD PhD; Yaron S. Rabinowitz MD; and J. Bradley Randleman MD Chapter 10 Evaluation and Diagnosis of Postoperative Corneal Ectasia J. Bradley Randleman MD; Maria A. Woodward MD MS; and Marcony R. Santhiago MD PhD Section II Corneal Cross-Linking for Corneal Ectasias Chapter 11 Corneal Cross-Linking for Progressive KeratoconusTobias Koller MD; Stefan Seiler MD; and Theo Seiler MD PhD Chapter 12 Corneal Cross-Linking for Postoperative Corneal EctasiaDavid Tabibian MD and Farhad Hafezi MD PhD Chapter 13 Corneal Cross-Linking for Pellucid Marginal Degeneration Leopoldo Spadea MD and Roberto Secondi MD Section III Corneal Cross-Linking Protocols and Complication Management Chapter 14 The Standard Protocol and Its Parameters Maria A. Woodward MD MS; David L. DeMill MD; Francis W. Price Jr MD; and Marianne O. Price PhD MBA Chapter 15 Corneal Cross-Linking Using Accelerated Protocols George D. Kymionis MD PhD; Konstantinos I. Tsoulnaras MD; and Chrysanthi Koutsandrea MD PhD Chapter 16 Epithelium-On Protocols: Conceptual/Basic Science Eberhard Spoerl PhD and Suphi Taneri MD Chapter 17 Transepithelial Corneal Cross-Linking in Progressive Keratoconus Frederik Raiskup MD PhD FEBO Chapter 18 Corneal Cross-Linking With IontophoresisPaolo Vinciguerra MD; Riccardo Vinciguerra MD; Fabrizio Camesasca MD; Vito Romano MD; and Pietro Rosetta MD Chapter 19 Cross-Linking Protocols in Thin Corneas Soosan Jacob MS FRCS DNB and Amar Agarwal MS FRCS FRCOphth Chapter 20 Pediatric Corneal Cross-Linking Joseph Frucht-Pery MD and Denise Wajnsztajn MD Chapter 21 Corneal Cross-Linking Complications and Management Karolinne Maia Rocha MD PhD; Koray Gümü? MD FEBOphth; and J. Bradley Randleman MD Section IV Corneal Cross-Linking Imaging and Diagnostic Evaluations Chapter 22 Measuring the Efficacy of Corneal Cross-Linking Using Advanced Corneal Biomechanical Diagnostic Modalities Renato Ambrósio Jr MD PhD; Marcella Q. Salomão MD; and Cynthia Roberts PhD Chapter 23 Measuring the Efficacy of Cross-Linking: Clinical Metrics J. Bradley Randleman MD and Praneetha Thulasi MD Chapter 24 Measuring Corneal Cross-Linking Efficacy: Biomechanical Measurement Approach Giuliano Scarcelli; Seok Hyun Yun; and J. Bradley Randleman MD Chapter 25 Confocal Microscopy in Corneal Cross-LinkingCosimo Mazzotta MD PhD and Luigi Fontana MD PhD Chapter 26 Optical Coherence Tomography Use in Corneal Cross-Linking Sumitra S. Khandelwal MD and J. Bradley Randleman MD Chapter 27 Epithelial Remodeling After Corneal Cross-Linking Karolinne Maia Rocha MD PhD and Sudeep Dilip Sunthankar MD Section V Cross-Linking Plus: Combination Procedures Chapter 28 Corneal Cross-Linking in Combination With Transepithelial Phototherapeutic Keratectomy: Cretan ProtocolGeorge D. Kymionis MD PhD; Michael A. Grentzelos MD; and Chrysanthi Koutsandrea MD PhD Chapter 29 Corneal Cross-Linking in Combination With Surface Ablation: Athens Protocol Anastasios John Kanellopoulos MD and George Asimellis PhD Chapter 30 Corneal Cross-Linking in Combination With Intracorneal Ring SegmentAylin K?l?ç MD and David Touboul MD Chapter 31 Corneal Cross-Linking in Combination With Phakic Intraocular Lenses Jose L. Güell MD PhD; Merce Morral MD PhD; Emilio J. Segovia MD; Oscar Gris MD PhD; Daniel Elies MD; and Felicidad Manero MD Chapter 32 Corneal Cross-Linking: Combined Treatment Options Efekan Coskunseven MD and Onurcan Sahin MSc Chapter 33 Corneal Cross-Linking as a Primary Refractive ProcedureGeorge D. Kymionis MD PhD; Dimitra M. Portaliou MD PhD FEBO; Michael A. Grentzelos MD; and Chrysanthi Koutsandrea MD PhD Section VI Cross-Linking for Infectious Keratitis: PACK-CXL Chapter 34 PACK-CXL Jes Mortensen MD and Karim Makdoumi MD PhD Chapter 35 PACK-CXL for Viral Keratitis and Acanthamoeba Keratitis Francis W. Price Jr MD and Marianne O. Price PhD MBA Section VII Other Uses for Cross-Linking Chapter 36 Corneal Cross-Linking for Corneal Stromal Edema Niels Ehlers MD PhD and Jesper Hjortdal MD PhD Chapter 37 Sclera Cross-Linking Brendan Geraghty BEng(Hons) MSc PhD and Ahmed Elsheikh BEng(Hon) MSc PhD Section VIII Current Controversies and Perspectives Chapter 38 Epithelium-On Treatments In Favor Steven E. Wilson MD and Andre A.M. Torricelli MD PhD Opposed Aldo Caporossi MD PhD FRCS; Antonio Villano MD; Stefano Baiocchi MD PhD; and Orsola Caporossi MD PhD Chapter 39 Corneal Cross-Linking Can Impact Limbal Stem Cells In Favor Johnny E. Moore FRCOphth PhD; David Schiroli PhD; and C.B. Tara Moore PhD Opposed Farhad Hafezi MD PhD and Sabine Kling PhD Chapter 40 Performing Corneal Cross-Linking After Definitive Signs of Ectasia Progression Are Detected Renato Ambrósio Jr MD PhD; Rosane de Oliveira Corrêa MD; and Rozalia Litewski Beildeck MD Chapter 41 Prophylactic Cross-Linking Combined With LASIK In FavorAnastasios John Kanellopoulos MD and George Asimellis PhD Opposed Theo Seiler MD PhD Chapter 42 Summary of Commercially Available Corneal Cross-Linking Units George O. Waring IV MD FACS; Susannah L. Brown MD; and Frederik Raiskup MD PhD FEBO Financial Disclosures Index
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