Curcumin for Neurological and Psychiatric Disorders (eBook, ePUB)

Neurochemical and Pharmacological Properties
Redaktion: Farooqui, Tahira; Farooqui, Akhlaq A.

• Format: ePub

Produktbeschreibung

Curcumin for Neurological and Psychiatric Disorders: Neurochemical and Pharmacological Properties focuses on the different molecular mechanisms underlying curcumin-mediated beneficial effects in neurological diseases. The book's editors discuss the neurochemical and pharmacological properties of curcumin, followed by the effect of curcumin in neurotraumatic diseases, neurodegenerative diseases, and neuropsychiatric diseases. The book also offers a perspective on future studies on the treatment of neurological disorders.

The beneficial effects of curcumin have been observed both in cultured cells and in animal models, thus paving the way for ongoing present and future human clinical trials. Curcumin produces antioxidant and anti-inflammatory effects not only by blocking oxidative stress and neuroinflammation in neurotraumatic and neurodegenerative diseases, but also by restoring cellular homeostasis and rebalancing redox equilibrium.

• Identifies molecular mechanisms of curcumin effects in neurological diseases
• Includes effects on neurotraumatic, neurodegenerative and psychiatric diseases
• Covers the antioxidant, anti-inflammatory and immunomodulatory effects of curcumin
• Examines curcumin's potential in developing new therapeutic drugs

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Produktdetails

• Verlag: Elsevier Science & Techn.
• Seitenzahl: 544
• Erscheinungstermin: 16. März 2019
• Englisch
• ISBN-13: 9780128154625
• Artikelnr.: 55720530

Autorenporträt

Akhlaq A. Farooqui is a leader in the field of signal transduction processes, lipid mediators, phospholipases, glutamate neurotoxicity, and neurological disorders. He is a research scientist in the Department of Molecular and Cellular Biochemistry at The Ohio State University. He has published cutting edge research on the role of phospholipases A2 in signal transduction processes, generation and identification of lipid mediators during neurodegeneration by lipidomics. He has studied the involvement of glycerophospholipid, sphingolipid-, and cholesterol-derived lipid mediators in kainic acid neurotoxicity, an experimental model of neurodegenerative diseases. Akhlaq A. Farooqui has discovered the stimulation of plasmalogen- selective phospholipase A2 in brains of patients with Alzheimer disease (AD). Stimulation of this enzyme may not only be responsible for the deficiency of plasmalogens in neural membranes of AD patients, but also be related to the loss of synapse in the AD.

Inhaltsangabe

1. Neurological and neuropsychiatric disorders
2. Curcumin: Historical background, chemistry, pharmacological action and potential therapeutic value
3. Curcumin in neurological disorders
4. Curcumin in neurological disorders: An overview
5. The potential role of curcumin in treatment and prevention for neurological disorders
6. The chemistry and biological activities of curcuminoids: Impacts on neurological disorders
7. Pharmacological effects of curcuminoids in neurological disorders
8. Anti-oxidant properties of curcumin: Impact on neurological disorders
9. Omics and epigenetics of polyphenol mediated neuroprotection: The curcumin perspective
10. Curcumin offers potential efficacy for treating Alzheimer's disease
11. Potential role of curcumin and its derivatives against Alzheimer Disease
12. Usefulness of curcumin analogs for the diagnosis and treatment of Alzheimer Disease
13. Potential therapeutic impacts of curcumin against age-related impaired cognition and memory
14. Potential therapeutic impacts of curcumin for improving memory impairment
15. Curcumin derivatives as metal-chelating agents: Implications for potential therapeutic agent for neurological disorders
16. Neuroprotective propensity of Curcumin: evidences in animal models; Mechanisms and its potential therapeutic value
17. Molecular mechanisms of action of curcumin and its relevance to some clinical conditions
18. Therapeutic potentials of curcumin in Parkinson's disease
19. Beneficial role of curcumin in preventing the aggregation of the Amyloid-? peptide in Alzheimer disease
20. Curcumin impact on multiple sclerosis
21. Potential therapeutic impacts of curcumin in treating epilepsy
22. The potential beneficial effects of curcumin in diabetic retinopathy
23. Current and combinative curcumin therapeutics for treating spinal cord injury
24. Curcumin and inflammatory brain diseases
25. Curcumin in depressive disorders
26. Summary, perspective and direction for future research