DNA Microarrays and Related Genomics Techniques (eBook, ePUB)

Design, Analysis, and Interpretation of Experiments
Redaktion: Allison, David B.; Edwards, Jode W.; Beasley, T. Mark; Page, Grier P.

• Format: ePub

Produktbeschreibung

Considered highly exotic tools as recently as the late 1990s, microarrays are now ubiquitous in biological research. Traditional statistical approaches to design and analysis were not developed to handle the high-dimensional, small sample problems posed by microarrays. In just a few short years the number of statistical papers providing approaches

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Produktdetails

• Verlag: Taylor & Francis eBooks
• Erscheinungstermin: 14. November 2005
• Englisch
• ISBN-13: 9781040199305
• Artikelnr.: 73256087

Autorenporträt

David B. Allison, Grier P. Page, T. Mark Beasley, Jode W. Edwards

Inhaltsangabe

Microarray Platforms and Blood Samples. Normalization of Microarray Data.
Microarray Quality Control and Assessment. Epistemological Foundations of
Statistical Methods for High-Dimensional Biology. The Role of Sample Size
on Measures of Uncertainty and Power. Pooling Biological Samples in
Microarray Experiments. Designing Microarrays for the Analysis of Gene
Expressions. Overview of Standard Clustering Approaches for Gene Microarray
Data Analysis. Cluster Stability. Dimensionality Reduction and
Discrimination. Modeling Affymetrix Data at the Probe Level. Parametric
Linear Models. The Use of Nonparametric Procedures in the Statistical
Analysis of Microarray Data. Bayesian Analysis of Microarray Data. False
Discovery Rate and Multiple Comparison Procedures. Using Standards to
Facilitate Interoperation of Heterogeneous Microarray Databases and
Analytic Tools. Post-Analysis Interpretation: What Do I Do with This Gene
List? Combining High Dimensional Biological Data to Study Complex Diseases
and Quantitative Traits.