Endotoxin Detection and Control in Pharma, Limulus, and Mammalian Systems (eBook, PDF)

Redaktion: Williams, Kevin L.

• Format: PDF

Produktbeschreibung

• Provides the reader with a specializd vantage point from which to view the interrelatedness of various general systems of science.
• Teaches microbiology, genetics, evolution, immunology as well as pharmaceutical manufacturing control including a view of the regulatory aspects.
• Shows how endotoxins presents a unique vantage of a long view of life as a struggle against prokaryotic invaders and can be seen as shaping the evolving genetics and survival mechanisms of multicellular life-forms.
• Presents the most up-to-date and thorough treatment of the subject as well as a host of interrelated topics written by a host of international experts and pioneers of industry.
• Includes access to thorough literaure review links on the books' sister website

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Produktdetails

• Verlag: Springer International Publishing
• Seitenzahl: 869
• Erscheinungstermin: 24. Juli 2019
• Englisch
• ISBN-13: 9783030171483
• Artikelnr.: 57197010

Autorenporträt

Kevin Williams graduated from Texas A&M in 1982 with a BS in Microbiology.  From there spent 30 years at Eli Lilly in Indianapolis.  After retirement he has been at Hospira, Lonza, GE, and now BioMerieux .

Inhaltsangabe

Introduction.- Section I Pharma.- Historical Perspectives.- Risk, Control and Compliance..- Sterility and Beyond.- LVPs and SMDs.- Specification Determination.- Static and Dynamic Models (Biodiversity and Heterogeneity) .- Test Development and Validation.- Diminishing Analytics.- Control in Biologics Manufacture.- Depyrogenation and Medical Devices.- Nanoparticles / Problematic Drug Types.- New Frontiers.- Section II Limulus.- Evolution, a Living Fossil and Other Model Arthropods.- Water, Water Everywhere.- Survival and Mass Extinction Events.- Limulus Soup / Hemolymph.- Is Innate Modeling Enough?.- A Foreboding.- Section III Mammalian.- Innate is Inborn.- The Host Response: Fever and Inflammation.- . Parallel Immune Systems: Architecture and Mechanisms.- Structural Change is Functional Change (Hand in Glove).- Endotoxin and Adjuvanticity in Vaccinology.- Advancesin Diagnostics.- The Big S.