Rodrick Wallace, Deborah Wallace

Gene Expression and Its Discontents (eBook, PDF)

The Social Production of Chronic Disease

• Format: PDF

Produktbeschreibung

Gene Expression and its Discontents examines a class of probability models describing how epigenetic context affects gene expression and organismal development, using the asymptotic limit theorems of information theory in a highly formal manner. Taking classic results on spontaneous symmetry breaking abducted from statistical physics in groupoid, rather than group, circumstances, the work suggests that epigenetic information sources act as analogs to a tunable catalyst, directing development into different characteristic pathways according to the structure of external signals. The results have significant implications for epigenetic epidemiology, in particular for understanding how environmental stressors, in a large sense, can induce a broad spectrum of developmental disorders in humans. The authors then apply the perspective to a number of chronic diseases broadly associated with obesity, using data at different scales of observation.

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Produktdetails

• Verlag: Springer US
• Seitenzahl: 227
• Erscheinungstermin: 30. Oktober 2009
• Englisch
• ISBN-13: 9781441914828
• Artikelnr.: 37347575

Autorenporträt

Rodrick Wallace is a research scientist in the Division of Epidemiology at the New York State Psychiatric Institute, affiliated with Columbia University's Department of Psychiatry. He has an undergraduate degree in mathematics and a PhD in physics from Columbia, and completed postdoctoral training in the epidemiology of mental disorders at Rutgers. He worked as a public interest lobbyist, including two decades conducting empirical studies of fire service deployment, and subsequently received an Investigator Award in Health Policy Research from the Robert Wood Johnson Foundation. In addition to material on public health and public policy, he has published peer reviewed studies modeling evolutionary process and heterodox economics, as well as many quantitative analyses of institutional and machine cognition. He publishes in the military science literature, and in 2019 received one of the UK MoD RUSI Trench Gascoigne Essay Awards.

Inhaltsangabe

Introduction.- 1. Toward new tools.- 2. Models of development.- 3. Groupoid symmetries.- 4. Epigenetic catalysis.- 5. Developmental disorders.- 6. An interim perspective.- 7. The obesity pandemic in the US.- 8. Coronary heart disease in the US. - 9. Cancer: a developmental perspective.- 10. Autoimmune disorders.- 11. Demoralization and obesity in Upper Manhattan.- 12. Death at an early age: AIDS and related mortality in New York City.- 13. Mental Disorders I: Western atomism and its culture-bound syndromes.- 14. Mental Disorders II: Psychopathology and sleep.- 15. Diabetes and Thyroid Cancer in Manhattan's Chinatown.- 16. Right-To-Work Laws and Alzheimer's Disease.- 17. Stress as an Environmental Exposure.- 18. Final Thoughts.- 19. Mathematical Appendix.