Genes, Development and Cancer (eBook, PDF)

The Life and Work of Edward B. Lewis
Redaktion: Lipshitz, Howard D.

• Format: PDF

Produktbeschreibung

While Edward B. ('Ed') Lewis is famous for his contributions to genetics anddev- opmental biology y, few have read his research papers. One reason for this is availability, man ny having been published in obscure journalsor as book chapters. A second is because his papers in those ?elds are very dif?cult to read. The dif?culty derives from the fact that Lewis has published infrequently, thus manypapers are condensed reviews of man nyyears' work presented largely in summary form rather than in detail. It is not unusual for the reader to have to infer the experimental methods, even the results, from a few sentences. Furthermore, he often presents his results in terms of abstract models; thus it can be dif?cult to separate the data from the models. Ama ajor goal of this book is to make Lewis' keypapers accessible to researchers and students. The papers are grouped into several sections that re?ect the changing focus of his research. Each section is preceded by commentary designed to place the papers in historical perspective, with respect to Lewis' own ideas as well as to those of the larger scienti?c community. The commentaries attempt to highlight the key methods and results-as well as the signi?cance-of each paper by explaining the science in terms that should be understandable to upper-level undergraduates, graduate students and professional researchers.

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Produktdetails

• Verlag: Springer US
• Seitenzahl: 557
• Erscheinungstermin: 6. Dezember 2012
• Englisch
• ISBN-13: 9781441989819
• Artikelnr.: 44184077

Inhaltsangabe

E. B. Lewis and His Science.
Lewis and the Nature of the Gene.
Star
recessive, a spontaneous mutation in Drosophila melanogaster. Proceedings of the Minnesota Academy of Science 7:23
26.
Another case of unequal crossing over in Drosophila melanogaster. Proceedings of the National Academy of Sciences USA 27:31
34.
The relation of repeats to position effect in Drosophila melanogaster. Genetics, 30:1377
166.
The pseudoallelism of white and apricot in Drosophila melanogaster. Proceedings of the National Academy of Sciences USA 38:953
961.
Pseudoallelism and gene evolution. Cold Spring Harbor Symposia on Quantitative Biology, 16:159
174.
The theory and application of a new method of detecting chromosomal rearrangements in Drosophila melanogaster. American Naturalist 88:225
239.
Some aspects of position pseudoallelism. American Naturalist 89:73
89.
Genes and gene complexes. Heritage from Mendel, pp. 17
47.
Lewis and the Genetic Control of Development.
Genes and developmental pathways. American Zoologist, 3:33
56.
A gene complex controlling segmentation in Drosophila. Nature, 276:565
570.
Genetic control of body segment differentiation in Drosophila.
Control of body segment differentiation in Drosophila by the bithorax gene complex.
Regulation of the genes of the bithorax complex in Drosophila. Cold Spring Harbor Symposia on Quantitative Biology, 50:155
164.
Lewis and the Molecular Control of Development.
Molecular genetics of the bithorax complex in Drosophila melanogaster. Science, 221:23
29.
The abdominal region of the bithorax complex. Cell, 43:81
96.
Transabdominal, a dominant mutant of the bithorax complex, produces sexually dimorphic segmental transformation of Drosophila. Genes and Development, 1:111
123.
Molecular basisof Transabdominal
a novel sexually dimorphic mutant of the bithorax complex of Drosophila. Proceedings of the National Academy of Sciences USA 90:1566
1570.
Sequence analysis of the cis
regulatory regions of the bithorax complex of Drosophila. Proceedings of the National Academy of Sciences USA 92:8403
8407.
Splits in fruitfuly Hox gene complexes. Nature, 380:116.
Evolution of the homeobox complex in the Diptera. Current Biology, 13:R587
R588.
Lewis and the Somatic Effects of Ionizing Radiation.
Leukemia and ionizing radiation. Science, 125:965&3x2013;972.
Thyroid radiation doses from fallout. Proceedings of the National Academy of Sciences 45:894
897.
Leukemia, multiple myeloma, and aplastic anemia in American radiologists. Science, 142:1492
1494.
Ionizing radiation and tumor production. In: Genetic Concepts and Neoplasia, Williams and Wilkins Co, pp. 57
73.
Letters: Leukemia, radiation, and hyperthyroidism. Science, 174:454.
Analysis of lung tumor mortality in the Batelle Beagle Lifespan experiment.
Ionizing radiation, cancer induction and radioactive fallout.
Homeosis: the first 100 years. Trends in Genetics, 10:341
343.
Remembering Sturtevant. Genetics, 141:1227
1230.
C. B. Bridges' repeat hypothesis and the nature of the gene. Genetics: in press.
Autobiographical sketch.
The bithorax complex: the first fifty years. Les Prix Nobel, 1995. Almquist & Wiksell International: Stockholm, Sweden, pp. 233
260.
Curriculum vitae of E. B. Lewis.
References.