Glutathione In The Nervous System (eBook, ePUB)

Redaktion: Shaw, Christopher Ari

• Format: ePub

Produktbeschreibung

The goal of this text is to focus readers attention on three major areas; the origin and localization of GSH in the nervous system; the multiple effects of GSH on neural health activity; and the potential for alterations on GSH status to lead to neurological damage of the type observed in amyotrophic lateral sclerosis, Parkinson's disease and other neurological disorders. The text also touches upon the additional roles of the antoxidant GSH, including possible neurotransmitter action, redox modulation of ionotropic receptor function, and neuroprotection against exicitoxic actions of glutamate.

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Produktdetails

• Verlag: Taylor & Francis eBooks
• Seitenzahl: 389
• Erscheinungstermin: 8. Oktober 2018
• Englisch
• ISBN-13: 9781351444613
• Artikelnr.: 56837613

Autorenporträt

Shaw\, Christopher Ari

Inhaltsangabe

1. Multiple Roles of Glutathione in the Nervous System Christopher Shaw 2. The Discovery of the GSH Receptor in Hydra and its Evolutionary Significance Howard Lenhoff 3. Carrier-Mediated GSH Transport at the Blood-Brain Barrier and Molecular Characterisation of Novel Brain GSH Transporters Ram Kannan
Jian-R. Yi
Berislav Zlokovic and Neil Kaplowitz 4. Antibodies to Glutathione: Production
Characterisation
and Immunocytochemical application to the Central Nervous System Ole Hjelle
E. Rinvik
D. Huster
W. Reichelt and Ole Ottersen 5. Role of Astrocytes in Maintaining Cerebral Glutathione Homeostasis and in Protecting the Brain Against Xenobiotics and Oxidative Stress Arthur Cooper 6. Glutathione and the Regulation of Apoptosis in the Nervous System Khalequz Zaman and Rajiv Ratan 7. Possible Modulation by Glutathione of Glutamatergic Neurotransmission Kiyokazu Ogita
Makato Shuto
Hiriko Maeda
Takao Minami and Yukio Yoneda 8. Glutathione and Glutathione Derivatives: Possible Modulators of Ionotropic Glutamate Receptors Reka Janaky
Vince Varga
Zsolt Jenei
Pirjo Saransaari and Simo Oja 9. Excitatory Actions of GSH on Neocortex Bryce Pasqualotto
Kenneth Curry and Christopher Shaw 10. Medicinal Chemistry of Glutathione and Glutathione Analogs in the Mammalian Central Nervous System Kenneth Curry 11. Glutathione in Brain Ageing and Neurodegenerative Disorders Gianni Benzi and Antonio Moretti 12. The Glutathione Redox State and Zinc Mobilisation from Metallothionein and other Proteins with Zinc-Sulphur Co-ordination Sites Wolfgang Maret 13. Glutathione Release and Nitrosoglutathione Presence in the CNS: Implications for Schizophrenia Michel Cuenod and Kim Quang Do 14. The Role of Altered Glutathione Status in the Development of Parkinson's Disease J. Sian
M. Gerlach and P. Riederer 15. Glutathione
Cysteine
and the Neuromelanin Pathway: Potential Roles in the Pathogenesis of Parkinson's Disease - a New Hypothesis Glenn Dryhurst 16. Free-Radical Toxicity in Amyotrophic Lateral Sclerosis Merit Cudkowicz
Robert Brown and Richard Smith 17. Oxidative Stress and Neurological Diseases: Is Glutathione Depletion a Common Factor? Jaswinder Bains and Christopher Shaw. Gianni Benzi
University of Pavia
Italy
Robert Brown
Massachusetts General Hospital
USA
Arthur Cooper
Cornell University Medical College
Merit Cudkowicz
Massachusetts General Hospital
USA
Michel Cuenod
University of Zurich
Switzerland
Kenneth Curry
Precision Biochemicals Inc.
Canada
Kim Quang Do
University of Zurich
Switzerland
Glenn Dryhurst
University of Oklahoma
USA
M. Gerlach
University of Bochum
Germany
Ole Hjelle
University of Oslo
Norway
D. Huster
University of Leipzig
Germany
Reka Janaky
University of Tampere Medical School
Finland
Zsolt Jenei
University of Tampere Medical School
Finland
Ram Kannan
USC School of Medicine
USA
Neil Kaplowitz
USC School of Medicine
USA
Howard Lenhoff
University of California
USA
Hiroko Maeda
Setsunan University
Japan
Wolfgang Maret
Harvard Medical School
USA
Takao Minami
Setsunan University
Japan
Antonio Moretti
University of Pavia
Italy
Kiyokazu Ogita
Setsunan University
Japan
Simo Oja
University of Tampere Medical School
Finland
Ole Ottersen
University of Oslo
Norway
Bryce Pasqualotto
University of British Columbia
Canada
Rajiv Ratan
Harvard Institutes of Medicine
USA
W. Reichelt
University of Leipzig
Germany
P. Reiderer
University of Wurzburg
Germany
E. Rinvik
University of Oslo
Norway
Pirjo Saransaari
University of Tampere Medical School
Finland
Christopher Shaw
University of British Columbia
Canada
Makoto Shuto
Setsunan University
Japan
J. Sian
University of Wurzburg
Germany
Richard Smith
The Centre for Neurologic Study
USA
Vince Varga
University of Tampere Medical School
Finland
Jian-R. Yi
USC School of Medicine
USA
Yukio Yoneda
Setsunan University
Japan
Khalequz Zaman
Harvard Institutes of Medicine
USA
Berislav Zlokovic
USC School of Medicine
USA.