Kenneth Kee

Granulomatosis polyangiitis, (Wegener Granulomatosis) A Simple Guide To The Condition, Diagnosis, Treatment And Related Conditions (eBook, ePUB)

• Format: ePub

Produktbeschreibung

This book describes Granulomatosis with polyangiitis (Wegener's Granulomatosis), Diagnosis and Treatment and Related Diseases
Granulomatosis with polyangiitis (Wegener's granulomatosis) is a disease that causes the small blood vessels (arterioles and capillaries) in the body to become inflamed.
Granulomatosis with polyangiitis (GPA) can lead to damage in major organs of the body.
It was formerly known as Wegener's granulomatosis.
Particularly, lungs, throat, nose, sinuses and kidneys become affected.
In the beginning, the symptoms are often vague, such as runny nose or prolonged otitis media that do not recover with standard treatment.
Symptoms from the lungs later develop with cough and breathing difficulty.
Mild fever, fatigue and general malaise are common.
Some people get joint pain, swelling around an eye or skin rash. '
Disease of the kidney is normally present late in the course of the disease.
The disease can be serious and life threatening and prompt treatment is important.
GPA is most frequent in middle-aged adults of northern European race.
It is infrequent in children, but has been observed in infants as young as 3 months old.
Causes
The exact cause is not known but it is an autoimmune disorder.
Granulomatosis with polyangiitis manifests itself as a so-called autoimmune disease, meaning that the immune system mistakenly attacks the body's own tissues.
Granulomatosis with polyangiitis is a disease that can become life threatening if not treated.
With the treatment methods available today, most patients recover.
Some will relapse and must be treated again.
Symptoms
Frequent sinusitis and bloody nose are the most frequent symptoms.
Other early symptoms are:
1. A fever that has no clear cause,
2. Night sweats,
3. Fatigue, and
4. A general ill feeling (malaise).
Other frequent symptoms may be:
1. Chronic ear infections
2. Pain, and sores around the opening of the nose
3. Cough with or without blood in the sputum
4. Chest pain and shortness of breath as the disease progresses
5. Loss of appetite and weight loss
6. Skin changes such as bruises and ulcers of the skin
7. Kidney problems
8. Bloody urine
9. Eye problems ranging from mild conjunctivitis to severe swelling of the eye
Diagnosis
When the doctor suspects the disease, it may be because of medical examination of the body showed presence of signs of the disease.
It will have blood tests and various imaging studies.
Detection of specific types of antibodies (cANCA), high blood sedimentation rate, or renal impairment strengthens the suspicion of the diagnosis.
A chest x-ray will be done to look for signs of lung disease.
Urinalysis is done to look for signs of kidney disease such as protein and blood in the urine.
Blood tests are done to rule out other illnesses:
1. Antinuclear antibodies
2. Anti-glomerular basement membrane (anti-GBM) antibodies
3. C3 and C4, cryoglobulins, hepatitis serologies, HIV
Tissue samples can help to confirm the diagnosis.
Treatment
It is essential to medically treat the patient for him or her to become healthy.
The treatment is lengthy, often lasting 2-3 years.
The patient will probably be treated with glucocorticoids
These are given along with other immunosuppresants that reduce down the immune response.
Medicines used with prednisone to treat GPA are:
1. Cyclophosphamide with high-dose glucocorticoids (criterion standard)
2. Rituximab
3. Methotrexate (oral or subcutaneous)
Plasma exchange may be indicated in patients with rapidly progressive renal disease
For the next two years the doctors normally used a maintenance chemotherapy, methotrexate.
Folic acid tablets are given to prevent deficiency.

TABLE OF CONTENT
Introduction
Chapter 1 Granulomatosis Polyangiitis (Wegener Granulomatosis...

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Produktdetails

• Verlag: Kenneth Kee
• Erscheinungstermin: 7. Mai 2019
• Englisch
• ISBN-13: 9780463726150
• Artikelnr.: 56533697

Autorenporträt

Dr. Kenneth Kee is a well-known medical doctor from Singapore who has been practicing medicine since 1972.
He graduated from the University of Singapore and furthered his studies with a Master of Science in Health Management in 1991, followed by a Ph.D. in Healthcare Administration in 1993.
Dr. Kee established Kee Clinic in 1974, located in the Holland Drive area of Singapore. The clinic has been a prominent feature of the community, offering general medical services for 5 decades.
Dr Kee also served his country Singapore as a national service police Inspector at night from 1975 to 1985 while working at his clinic during the day.
He had served as a police guard to the Woodland Petroleum Tanks at night during the Indonesian Confrontation period, took part in police rounds at night in the Beach Road area and taught First aid and emergency resuscitation to Police recruits.
He received the Singapore Police Bicentennial 2020 Medallion on 1st March 2024 as recognition for his work in the Singapore Police.
Even as he grew older, Dr. Kee continued to work actively in his clinic, although he eventually reduced his consultation hours.
Beyond his medical career, Dr. Kee is also an author.
He started writing about medical conditions in 2007, using blogs and other online platforms to share his knowledge with a broader audience.
Over time, he published various books, many of which provide simple and accessible guides to different health conditions.
His works include "A Family Doctor's Tale," "My Personal Singapore History," and numerous medical guides, available through platforms like Amazon.
His books often combine his personal experiences as a family doctor with insights into Singapore's healthcare system and history.
Dr. Kee has written extensively on health topics, contributing to both medical literature and general knowledge resources.

Dr. Kenneth Kee has written numerous books, primarily focused on health education and personal experiences as a family doctor. Some of his notable titles include:
"A Family Doctor's Tale"
This book is a blend of Dr. Kee's personal experiences and his reflections on being a family doctor in Singapore. It's a great choice if you're looking for a narrative that combines both medical knowledge and human stories.
"Specialized Medical Conditions"
Books like **"Congestive Heart Failure: Diagnosis and Treatment"** focus on specific conditions, offering in-dept...