Gary S. Silverman, Philip E. Rakita

Handbook of Grignard Reagents (eBook, ePUB)

• Format: ePub

Produktbeschreibung

This handbook provides the theoretical and practical information necessary to explore new applications for Grignard reagents on a day-to-day basis, presenting a comprehensive overview of current research activities in Grignard chemistry. This book surveys specific reactions and applications of Grignard reagents, organized by type of substrate and t

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Produktdetails

• Verlag: Taylor & Francis eBooks
• Seitenzahl: 736
• Erscheinungstermin: 25. April 1996
• Englisch
• ISBN-13: 9781040214152
• Artikelnr.: 73255872

Autorenporträt

Gary S. Silverman, Philip E. Rakita

Inhaltsangabe

Part 1 Methods of Grignard reagent preparation: common method of Grignard
reagent preparation; preparation of Grignard reagents from olefins and
acetylenes; magnesium activation. Part 2 Safe handling practices: safe
handling practices of industrial scale Grignard reagents. Part 3 Analyses
of Grignard reagents: wet analyses of Grignard reagents; infrared and raman
spectroscopy; nuclear magnetic resonance analysis of Grignard reagents;
crystal structures of Grignard reagents. Part 4 Mechanisms and
structure-reactivity relationships: mechanism of Grignard reagent
formulation; mechanism of reactions in Grignard reagents;
structure-reactivity relationships; the composition of Grignard reagents in
solution - the Schlenk equilibrium and its effect on reactivity; effect of
tris(pyrazolyl)hydrobotato ligation. Part 5 General reactions of Grignard
reagents: nucleophilic substitution with electrophilic organic, main group
and transition metal species; nucleophilic addition to unconjugated C-C
multiple bond; nucleophilic addition of C-C multiple bonds - O, S, N, P;
nucleophilic addition to conjugated carbon-carbon bonds; nucleophilic
addition to conjugated carbon-heteroatom multiple bonds - O, S, N;
nucleophilic addition to organometallic vinylidene and allyl complexes.
Part 6 Special topics - applications and reactions of Grignard reagents:
the Barbier reaction; Grignard reagents as bases; Sn2 versus Sn21;
dihalide-derived di-Grignard reagents - preparation and reactions;
formation and reactions of substituted (2-butene-1,4-diyl)magnesium
complexes; spiroannulations using substituted (2-butene-1,4-diyl)magnesium
complexes; asymmetric synthesis using Grignard reagents; metal-catalyzed
reactions; the preparation of 1,1-bimetallics of magnesium and zinc;
alkynyl Grignard reagents and their uses; Grignard reagents and silanes;
Ziegler-Natta catalysis; organomagnesium compounds as polymerization
initiators.