High-Throughput Lead Optimization in Drug Discovery (eBook, ePUB)

Redaktion: Kshirsagar, Tushar

• Format: ePub

Produktbeschreibung

A Single Source on Parallel Synthesis for Lead Optimization

The end of the previous millennium saw an explosion in the application of parallel synthesis techniques for making compounds for high-throughput screening. Over time, it became clear that more thought in the design phase of library development is necessary to generate high qualit

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Produktdetails

• Verlag: Taylor & Francis eBooks
• Erscheinungstermin: 4. März 2008
• Englisch
• ISBN-13: 9781040202074
• Artikelnr.: 72524921

Autorenporträt

Tushar Kshirsagar

Inhaltsangabe

Introduction and Review. Application of Parallel Synthesis to the
Optimization of Inhibitors of the ZipA-FtsZ Protein-Protein Interaction.
Case Studies of Parallel Synthesis in Hit Identification, Hit Exploration,
Hit-to-Lead, and Lead Optimization Programs. A Successful Application of
Parallel Synthesis to Computer-Assisted Structural Optimization of New
Leads Targeting Human Immunodeficiency Virus-1 Reverse Transcriptase: The
Case of Acylthiocarbamates and Thiocarbamates. How High-Throughput
Medicinal Chemistry Can Expedite Lead Discovery, Lead Optimization, and
Beyond. Rapid Lead Identification of Inhibitors of Adenine Nucleotide
Translocase: A Case Study of Applying Combinatorial Chemistry Techniques in
Drug Discovery. Parallel Synthesis of Anticancer, Antiinflammatory, and
Antiviral Agents Derived from L-and D-Amino Acids. Application of
Solid-Phase Parallel Synthesis in Lead Optimization Studies.
High-Throughput Solid-Phase Synthesis of Nucleoside-Based Libraries in the
Search for New Antibiotics.