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Hirschsprung's disease is a congenital disorder causing blockage of the large intestine.
It happens due to poor muscle movement in the bowel.
The underlying pathology is the absence of parasympathetic ganglion cells in the myenteric and sub-mucosal plexus of the rectum, and sometimes also in the colon.
Normally 24h) is very important because:
50% of all Hirschsprung's patients do not pass meconium within 36h
50% of all children with delayed passage of meconium have Hirschsprung's disease
Rectal examination often reveals the narrowing of the rectosigmoid colon.
When the
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Produktbeschreibung
Hirschsprung's disease is a congenital disorder causing blockage of the large intestine.
It happens due to poor muscle movement in the bowel.
The underlying pathology is the absence of parasympathetic ganglion cells in the myenteric and sub-mucosal plexus of the rectum, and sometimes also in the colon.
Normally 24h) is very important because:
50% of all Hirschsprung's patients do not pass meconium within 36h
50% of all children with delayed passage of meconium have Hirschsprung's disease
Rectal examination often reveals the narrowing of the rectosigmoid colon.
When the finger is withdrawn, there may be evacuation of a watery stool.
Symptoms in older children:
1. Constipation that slowly becomes worse
2. Fecal impaction
3. Malnutrition
4. Slow growth
5. Swollen belly
Milder cases may not be diagnosed until the baby is older.
During a physical exam, the doctor may be able to feel loops of bowel in the swollen abdomen.
A rectal exam may indicate tight muscle tone in the rectal muscles.
Tests used to help diagnose Hirschsprung's disease may be:
1. Abdominal x-ray
2. Anal manometry (a balloon is inflated in the rectum to measure pressure in the area)
3. Barium enema
4. Rectal biopsy
Treatment
A procedure called serial rectal irrigation helps alleviate pressure in (decompress) the bowel.
The abnormal section of colon must be removed using surgery.
Most often, the rectum and abnormal part of the colon are removed.
The healthy part of the colon is then pulled down and attached to the anus.
Sometimes this can be done in 1 operation.
It is often done in 2 parts.
A colostomy is performed first.
The other part of the procedure is done later in the child's first year of life.
The most often performed repairs are the Swenson, Duhamel, and Soave procedures.
Several other creative methods have been done, such as:
1. A modified transanal method with trans-abdominal open or laparoscopic assistance,
2. Single-incision laparoscopic endorectal pull-through (SILEP), and
3. Natural orifice trans-luminal endoscopic surgery (NOTES)
Regeneration cell treatments are under studies to return function in aganglionic intestine.
TABLE OF CONTENT
Introduction
Chapter 1 Hirschsprung's Disease
Chapter 2 Causes
Chapter 3 Symptoms
Chapter 4 Diagnosis
Chapter 5 Treatment
Chapter 6 Prognosis
Chapter 7 Intussusception
Chapter 8 Volvulus
Epilogue


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Autorenporträt
Dr. Kenneth Kee is a well-known medical doctor from Singapore who has been practicing medicine since 1972.
He graduated from the University of Singapore and furthered his studies with a Master of Science in Health Management in 1991, followed by a Ph.D. in Healthcare Administration in 1993.
Dr. Kee established Kee Clinic in 1974, located in the Holland Drive area of Singapore. The clinic has been a prominent feature of the community, offering general medical services for 5 decades.
Dr Kee also served his country Singapore as a national service police Inspector at night from 1975 to 1985 while working at his clinic during the day.
He had served as a police guard to the Woodland Petroleum Tanks at night during the Indonesian Confrontation period, took part in police rounds at night in the Beach Road area and taught First aid and emergency resuscitation to Police recruits.
He received the Singapore Police Bicentennial 2020 Medallion on 1st March 2024 as recognition for his work in the Singapore Police.
Even as he grew older, Dr. Kee continued to work actively in his clinic, although he eventually reduced his consultation hours.
Beyond his medical career, Dr. Kee is also an author.
He started writing about medical conditions in 2007, using blogs and other online platforms to share his knowledge with a broader audience.
Over time, he published various books, many of which provide simple and accessible guides to different health conditions.
His works include "A Family Doctor's Tale," "My Personal Singapore History," and numerous medical guides, available through platforms like Amazon.
His books often combine his personal experiences as a family doctor with insights into Singapore's healthcare system and history.
Dr. Kee has written extensively on health topics, contributing to both medical literature and general knowledge resources.

Dr. Kenneth Kee has written numerous books, primarily focused on health education and personal experiences as a family doctor. Some of his notable titles include:
"A Family Doctor's Tale"
This book is a blend of Dr. Kee's personal experiences and his reflections on being a family doctor in Singapore. It's a great choice if you're looking for a narrative that combines both medical knowledge and human stories.
"Specialized Medical Conditions"
Books like **"Congestive Heart Failure: Diagnosis and Treatment"** focus on specific conditions, offering in-dept...