Kenneth Kee

Hypertrichosis, (Werewolf syndrome) A Simple Guide To The Condition, Diagnosis, Treatment And Related Conditions (eBook, ePUB)

• Format: ePub

Produktbeschreibung

This book describes Hypertrichosis (Werewolf syndrome), Diagnosis and Treatment and Related Diseases

While reading about genetic diseases, I came across this disease called hypertrichosis (which means excessive hairs on the body)
There was also a story in the Middle Ages of a family originally from Canary Islands with a father Petros Gonzales who look like a wolf man and his normal wife and 2 daughters who were as hairy as the father.
It reminded me of the story Beauty and the Beast.

Hypertrichosis, also called werewolf syndrome, is a disorder featured by excessive hair growth anywhere on a person's body
Hypertrichosis can be congenital (present at birth) or acquired (arises later in life).
The unusual hair growth may cover the face and body or happen in small patches.
Congenital hypertrichosis
This is a genetic disease that is be inherited in an autosomal dominant manner.
Using fluorescence in situ hybridization (FISH), doctors identified a pericentric inversion of chromosome 8, inv (8) (p11.2q22) with an insertion of the q23-24 region into a more proximal region of the long arm of chromosome 8, most probably at the q13 band, and a complex deletion in 8q23 encompassing four separate chromosomal breakpoints
A mutation in MAP2K6 is believed to cause Terminal Hypertrichosis.

Acquired hypertrichosis
Unlike congenital hypertrichosis, the acquired form of the disease is likely to form later in life.
It causes 2 types of hair other than lanugo: vellus hair or terminal hair.
Excessive hair may form in small patches or on all hair-growing regions of a person's body.
Acquired hypertrichosi depicts excess hair growth that forms in a person after birth.
The hair is normally un-pigmented vellus hair or may have pigmented terminal hair.
Excess hair growth may be localized to a particular region or generalized and spreading over all hair-bearing areas of the body.
Drugs most often produce acquired generalized hypertrichosis:
1. Antibiotics such as streptomycin
2. Anti-inflammatory drugs such as benoxaprofen and corticosteroids
3. Vasodilators (diazoxide, minoxidil, prostaglandin E1)
4. Diuretics (acetazolamide)
5. Anticonvulsants (phenytoin)
6. Immunosuppressives (cyclosporine, mycophenolate mofetil)
7. Psoralens (methoxypsoralen, trimethylpsoralen)
8. Antiseptic agents (hexachlorobenzene)
9. Chelators (penicillamine)
10. Interferon-alpha
11. Fenoterol
12. EGFR inhibitors (cetuximab, panitumumab, erlotinib, gefitinib)
While drugs are normally the cause, acquired generalized hypertrichosis can also be observed in:
1. Traumatic brain injuries,
2. Juvenile hypothyroidism,
3. Juvenile dermatomyositis,
4. Acromegaly,
5. Malnutrition, and
6. Advanced HIV infection.
The diagnosis of hypertrichosis is made on medical and histological findings of the hair
Lanugo hairs are likely to be non-pigmented.
Vellus hair can be pigmented or non-pigmented
Treatment
The medical treatment of eflornithine (Vaniqa cream) 13.9% or the hair removal by methods of repeated shaving, depilatory methods (e.g., chemical, electric methods), or bleaching can cause an improvement in the hypertrichosis patient's appearance.
Antidepressant medicines may be required in patients with psychological depression.
Laser hair removal has been indicated as a treatment method but there are conflicting reports about the efficacy of lasers in eliminating the vellus hairs in congenital hypertrichosis lanuginosa.
40-80% reduction in unwanted hair is obtained using the Q-switched Nd:YAG laser after the application of a topical carbon-based solution.
This therapy is a well-tolerated method of hair removal in children since the lower fluencies required led to reduced pain during treatment

TABLE OF CONTENT
Introduction
Chapter 1 Hypertrichosis (Werewolf syndrome)
Chapt...

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Produktdetails

• Verlag: Kenneth Kee
• Erscheinungstermin: 7. Dezember 2019
• Englisch
• ISBN-13: 9780463346020
• Artikelnr.: 75904535

Autorenporträt

Dr. Kenneth Kee is a well-known medical doctor from Singapore who has been practicing medicine since 1972.
He graduated from the University of Singapore and furthered his studies with a Master of Science in Health Management in 1991, followed by a Ph.D. in Healthcare Administration in 1993.
Dr. Kee established Kee Clinic in 1974, located in the Holland Drive area of Singapore. The clinic has been a prominent feature of the community, offering general medical services for 5 decades.
Dr Kee also served his country Singapore as a national service police Inspector at night from 1975 to 1985 while working at his clinic during the day.
He had served as a police guard to the Woodland Petroleum Tanks at night during the Indonesian Confrontation period, took part in police rounds at night in the Beach Road area and taught First aid and emergency resuscitation to Police recruits.
He received the Singapore Police Bicentennial 2020 Medallion on 1st March 2024 as recognition for his work in the Singapore Police.
Even as he grew older, Dr. Kee continued to work actively in his clinic, although he eventually reduced his consultation hours.
Beyond his medical career, Dr. Kee is also an author.
He started writing about medical conditions in 2007, using blogs and other online platforms to share his knowledge with a broader audience.
Over time, he published various books, many of which provide simple and accessible guides to different health conditions.
His works include "A Family Doctor's Tale," "My Personal Singapore History," and numerous medical guides, available through platforms like Amazon.
His books often combine his personal experiences as a family doctor with insights into Singapore's healthcare system and history.
Dr. Kee has written extensively on health topics, contributing to both medical literature and general knowledge resources.

Dr. Kenneth Kee has written numerous books, primarily focused on health education and personal experiences as a family doctor. Some of his notable titles include:
"A Family Doctor's Tale"
This book is a blend of Dr. Kee's personal experiences and his reflections on being a family doctor in Singapore. It's a great choice if you're looking for a narrative that combines both medical knowledge and human stories.
"Specialized Medical Conditions"
Books like **"Congestive Heart Failure: Diagnosis and Treatment"** focus on specific conditions, offering in-dept...