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This volume emphasizes areas of insulin pharmacology where rapid progress has occurred during recent years, including its chemistry, structure, pancreatic secretion, receptor interaction and molecular biology and cellular responses.
This volume emphasizes areas of insulin pharmacology where rapid progress has occurred during recent years, including its chemistry, structure, pancreatic secretion, receptor interaction and molecular biology and cellular responses.
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Inhaltsangabe
I. Insulin.- 1 Insulin Chemistry.- 2 Insulin Structure.- 3 Mutant Human Insulins and Insulin Structure-Function Relationships.- II. Biosynthesis, Secretion, and Degradation.- 4 The Biosynthesis of Insulin.- 5 Insulin Gene Regulation.- 6 Regulation of Insulin Release by the Intracellular Mediators Cyclic AMP, Ca2+, Inositol 1, 4, 5-Trisphosphate, and Diacylglycerol.- 7 The Role of Cholecystokinin and Other Gut Peptides on Regulation of Postprandial Glucose and Insulin Levels.- 8 Insulin-Degrading Enzyme.- III. Insulin Receptor.- 9 Insulin Receptor Structure.- 10 Insulin Receptor-Mediated Transmembrane Signalling.- 11 The Insulin Receptor Tyrosine Kinase.- 12 Receptor-Mediated Internalization and Turnover.- 13 Insulin-like Growth Factor I Receptors.- IV. Effect of Insulin on Cellular Metabolism.- 14 Second Messengers of Insulin Action.- 15 Insulin Regulation of Protein Phosphorylation.- 16 Effects of Insulin on Glycogen Metabolism.- 17 Insulin-Sensitive cAMP Phosphodiesterase.- 18 Regulation of Gene Expression by Insulin.- 19 Insulin, Membrane Polarization, and Ionic Currents.- 20 Insulin Regulation of Metabolism Relevant to Gluconeogenesis.
I. Insulin.- 1 Insulin Chemistry.- 2 Insulin Structure.- 3 Mutant Human Insulins and Insulin Structure-Function Relationships.- II. Biosynthesis, Secretion, and Degradation.- 4 The Biosynthesis of Insulin.- 5 Insulin Gene Regulation.- 6 Regulation of Insulin Release by the Intracellular Mediators Cyclic AMP, Ca2+, Inositol 1, 4, 5-Trisphosphate, and Diacylglycerol.- 7 The Role of Cholecystokinin and Other Gut Peptides on Regulation of Postprandial Glucose and Insulin Levels.- 8 Insulin-Degrading Enzyme.- III. Insulin Receptor.- 9 Insulin Receptor Structure.- 10 Insulin Receptor-Mediated Transmembrane Signalling.- 11 The Insulin Receptor Tyrosine Kinase.- 12 Receptor-Mediated Internalization and Turnover.- 13 Insulin-like Growth Factor I Receptors.- IV. Effect of Insulin on Cellular Metabolism.- 14 Second Messengers of Insulin Action.- 15 Insulin Regulation of Protein Phosphorylation.- 16 Effects of Insulin on Glycogen Metabolism.- 17 Insulin-Sensitive cAMP Phosphodiesterase.- 18 Regulation of Gene Expression by Insulin.- 19 Insulin, Membrane Polarization, and Ionic Currents.- 20 Insulin Regulation of Metabolism Relevant to Gluconeogenesis.
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