IUTAM Symposium on Cellular, Molecular and Tissue Mechanics (eBook, PDF)

Proceedings of the IUTAM symposium held at Woods Hole, Mass., USA, June 18-21, 2008
Redaktion: Garikipati, Krishna; Arruda, Ellen M.

• Format: PDF

Produktbeschreibung

Mechanics plays a central role in determining form and function in biology. This holds at the cellular, molecular and tissue scales. At the cellular scale, mechanics in?uences cell adhesion, cytoskeletal dynamics and the traction that the cell can generate on a given substrate. All of these in turn - fect the cellular functions of migration, mitosis, phagocytosis, endocytosis and stem cell differentiation among others. Indeed, if cells do not develop the appropriate stresses, they are unviable and die. These aspects of cell mechanics are frequently used by mainstream biologists, as traditional mechanicians may be surprised to learn. There is a growing view that many functions of the cell are mechanical in nature even though chemical signals play crucial roles in the processes. Free energy barriers control transitions between different conformations of vir- ally every macromolecule including DNA, RNA, the adhesion protein integrin, the motor protein myosin, and the proteins vinculin and talin that link the cytoskeleton to focal adhesions. The strain energy can be a signi?cant component of the total free energy barrier. For binding to take place, the macromolecules need to be in conf- mational states that expose chemical groups without steric hinderance. The kinetics of chemical reactions are therefore strongly in?uenced by the conformational strain energy.

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Produktdetails

• Verlag: Springer Netherlands
• Seitenzahl: 285
• Erscheinungstermin: 1. Dezember 2009
• Englisch
• ISBN-13: 9789048133482
• Artikelnr.: 37410951

Inhaltsangabe

Tissue Mechanics.- Experimental and Computational Investigation of Viscoelasticity of Native and Engineered Ligament and Tendon.- A Comparison of a Nonlinear and Quasilinear Viscoelastic Anisotropic Model for Fibrous Tissues.- Hysteretic Behavior of Ligaments and Tendons: Microstructural Analysis of Damage, Softening and Non-Recoverable Strain.- On Measuring Stress Distributions in Epithelia.- A Viscoelastic Anisotropic Model for Soft Collageneous Tissues Based on Distributed Fiber-Matrix Units.- Cell-substrate Interactions.- Chemical and Mechanical Micro-Diversity of the Extracellular Matrix.- Tissue-to-Cellular Deformation Coupling in Cell-Microintegrated Elastomeric Scaffolds.- Orientational Polarizability and Stress Response of Biological Cells.- Universal Temporal Response of Fibroblasts Adhering on Cyclically Stretched Substrates.- Mechanics of DNA.- Elastic and Electrostatic Model for DNA in Rotation-Extension Experiments.- Shape and Energetics of DNA Plectonemes.- Mechanics of Biopolymer Networks.- Constitutive Models for the Force-Extension Behavior of Biological Filaments.- Small Strain Topological Effects of Biopolymer Networks with Rigid Cross-Links.- Cell adhesion.- An Observation on Bell's Model for Molecular Bond Separation Under Force.- A Theoretical Study of the Thermodynamics and Kinetics of Focal Adhesion Dynamics.- Tension-Induced Growth of Focal Adhesions at Cell-Substrate Interface.- Pattern Formation and Force Generation by Cell Ensembles in a Filamentous Matrix.- Mechano-Chemical Coupling in Shell Adhesion.- Catch-to-Slip Bond Transition in Biological Bonds by Entropic and Energetic Elasticity.- Growth.- Dilation and Hypertrophy: A Cell-Based Continuum Mechanics Approach Towards Ventricular Growth and Remodeling.- A Morpho-Elastic Modelof Hyphal Tip Growth in Filamentous Organisms.- Extracellular Control of Limb Regeneration.- Poroelasticity of Bone.- Bone Composite Mechanics Related to Collagen Hydration State.