Jose Chacko, Donald B. Chalfin, Ian Seppelt, Swapnil Pawar, Gagan Brar

Landmark Studies in Critical Care (eBook, PDF)

The Evidence Base of Contemporary Practice

• Format: PDF

Produktbeschreibung

The book is a curated collection of groundbreaking papers entrenched in evidence-based medicine to provide trainees and practitioners in critical care medicine with a handy tool for reference. This compilation highlights pivotal research papers that have significantly influenced clinical practice. The studies in this book are carefully selected based on a rigorous methodology and cover a wide range of critical topics. The studies present robust findings and offer guidance on improving clinical outcomes.

Critical care medicine is a relatively new area of specialization and many contentious topics have been the focus of research over the years. In the contemporary era of evidence-based medicine, researchers continue to search for reliable evidence. Despite an abundance of research, few papers have truly shaped the landscape. The book presents an overview of critical care research that has significantly influenced the field and impacted clinical practice. These studies represent landmarks in the history of critical care medicine, spearheaded by leaders in their research.

The book is designed to appeal to both trainees and practitioners in the field of critical care medicine.

---

Dieser Download kann aus rechtlichen Gründen nur mit Rechnungsadresse in A, B, BG, CY, CZ, D, DK, EW, E, FIN, F, GR, HR, H, IRL, I, LT, L, LR, M, NL, PL, P, R, S, SLO, SK ausgeliefert werden.

Produktdetails

• Verlag: Springer Nature Singapore
• Seitenzahl: 664
• Erscheinungstermin: 26. September 2025
• Englisch
• ISBN-13: 9789819506736
• Artikelnr.: 75531388

Autorenporträt

Dr. Jose Chacko, MD, DA, DNB, EDIC, MBA, graduated in medicine and completed postgraduation in anesthesia from Medical College, Trivandrum. He is currently a senior consultant in critical care medicine at Narayana Health, Bangalore. He received advanced training in critical care medicine from leading hospitals in Australia and worked as a consultant in anesthesia and critical care with the National Health Service (NHS) in the United Kingdom. He has completed the European Diploma in Intensive Care (EDIC) from the European Society of Intensive Care Medicine (ESICM). He is a leading practitioner and teacher of critical care medicine in India. He has several publications in peer-reviewed journals and contributed to critical care and emergency medicine textbooks. He is a prolific speaker and participates in academic meetings focused on critical care medicine.

Dr. Donald B. Chalfin, MD MS MPH FCCP FCCM, is an American board-certified intensivist and internist. He graduated from the Mount Sinai School of Medicine and completed his residency in internal medicine at the Long Island Jewish Medical Center, and his fellowship at the Memorial Sloan-Kettering Cancer Center. He has a master of health management (MS) degree from the Robert F. Wagner Graduate School of Public Health of New York University and a master of public health (MPH) degree from the Bloomberg School of Public Health of Johns Hopkins University. He currently serves as an adjunct professor in the department of epidemiology and biostatistics of the University of California, San Francisco. He has published in several areas of critical care medicine, including sepsis, scoring systems, cost-effectiveness analysis, and decision theory. He currently serves on the editorial board for the critical care medicine journal and contributes multiple editorial pieces. He has also been active in several organizations including the Society of Critical Care Medicine (SCCM).

Dr. Ian Seppelt, FANZCA, FCICM, graduated in medicine from the University of Sydney and working as a senior specialist in intensive care medicine at the Nepean Hospital, Sydney, and the University of Sydney Medical School, clinical professor in the Faculty of Medicine and Health Sciences, Macquarie University, professorial fellow at the George Institute for Global Health, Sydney and adjunct professor (research) at Monash University. His research interests include critical care infection (including gut microbiology in critical illness), fluid resuscitation, complex airway management, and sedation and delirium in intensive care. He is also interested in neuroanaesthesia, neurocritical care, and clinical research ethics in critical illness. He has received NHMRC/MRFF grant funding for the SuDDICU, SPICE, and REMAP-CAP research programs.

Dr. Swapnil Pawar, MD, FCICM, EDIC, CHSE, graduated from Maharashtra University of Health Sciences, Nashik. He completed his postgraduation in anesthesia from the Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh. He is a fellow of the College of Intensive Care Medicine (CICM), Australia and New Zealand, and has also completed his European Diploma in Intensive Care (EDIC) with the European Society of Intensive Care Medicine (ESICM). He is currently working as a consultant intensivist at the St. George Hospital in Sydney and is the supervisor of training for the College of Intensive Care Medicine. He is also pursuing his PhD in the field of cognitive load theory. He is a trained mediator/negotiator and a donation medical specialist with the New South Wales organ and tissue donation services. He is interested in simulation and medical education and is a certified simulation healthcare educator (CHSE) with the Society of Simulation in Healthcare (SSH).

Dr. Gagan Brar, MD, DNB, EDIC, IDCCM, graduated in medicine and completed postgraduation in anesthesia from Kasturba Medical College, Manipal. She underwent training in critical care medicine at Manipal Hospital and Fortis Hospital, Bangalore, India. She is a fellow of the National Board of Examinations in Critical Care Medicine. She has completed the European Diploma in Intensive Care (EDIC) with the European Society of Intensive Care Medicine (ESICM). She is currently working as a consultant in critical care medicine, at Aster RV Hospital, Bangalore. Dr. Brar has published several papers in peer-reviewed journals and is an invited speaker for major academic meetings in critical care medicine.

Inhaltsangabe

Part I: Mechanical Ventilation and Respiratory Failure.- 1. Neuromuscular Blockers in Acute Respiratory Distress Syndrome: The ACURASYS Trial.-2. Ventilation with Low Tidal Volumes in Acute Respiratory Distress Syndrome: The ARDS-Net Trial.- 3. Prone Ventilation in Severe Acute Respiratory Distress Syndrome: The PROSEVA Trial.- 4. Timing of Tracheostomy: Early vs. Late Tracheostomy in Mechanically Ventilated Patients: The TRACMAN Trial.- 5. High-Frequency Oscillation in Acute Respiratory Distress Syndrome: The OSCILLATE Trial.- 6. High-Frequency Oscillation in Acute Respiratory Distress Syndrome: The OSCAR Trial.- 7. Positive End-Expiratory Pressure Setting in Acute Respiratory Distress Syndrome: The EXPRESS Trial.- 8. Comparison of Different Methods of Weaning from Mechanical Ventilation: Esteban et al.- 9. Noninvasive Ventilation for Chronic Obstructive Pulmonary Disease: Brochard et al.- Part II: Fluid Management.- 10. Albumin vs. Normal Saline for Resuscitation: The SAFE Trial.- 11. Albumin Replacement in Severe Sepsis and Septic Shock: The ALBIOS Trial.- 12. Hydroxyethyl Starch vs. Normal Saline for Fluid Resuscitation: The CHEST Trial.- 13. Balanced Crystalloid vs. Normal Saline for Resuscitation: The SMART Trial.- 14. Balanced Crystalloid vs. Normal Saline for Resuscitation: The BaSICS Trial.- 15. Balanced Multielectrolyte Solution vs. Normal Saline for Resuscitation: The PLUS Trial.- 16. Conservative vs. Liberal Fluid Management in ARDS: The FACTT Trial.- Part III: Cardiopulmonary Resuscitation.- 17. Compression-Only Cardiopulmonary Resuscitation in Out-of-Hospital Cardiac Arrest: The DART Trial.- Part IV: Neurosciences.- 18. Intracranial Pressure Monitoring and Outcomes in Traumatic Brain Injury: The BEST-TRIP Trial.- 19. Methylprednisolone in Severe Traumatic Brain Injury: The CRASH Trial.- 20. Thrombectomy at 6 to 24 Hours Following Stroke with Mismatch Between Deficit and Infarct Size: The DAWN Trial.- 21. Decompressive Craniectomy in Severe Diffuse Traumatic Brain Injury: The DECRA Trial.- 22. Decompressive Craniectomy for Intracranial Hypertension Following Traumatic Brain Injury: The RESCUEicp Trial.- 23. Decompressive Craniectomy in Older Patients with Extensive Middle-Cerebral-Artery Stroke: The DESTINY II Trial.- 24. Intravenous Thrombolysis Between 3 4.5 Hours After Stroke: The ECASS 3 Trial.- 25. A Comparison of Four Treatments for Generalized Convulsive Status Epilepticus: Treiman et al.- 26. Neurosurgical Clipping vs. Endovascular Coiling in Ruptured Intracranial Aneurysms: The ISAT Trial.- 27. Tissue Plasminogen Activator for Acute Ischemic Stroke: The NINDS Trial.- 28. Tranexamic Acid in Traumatic Brain Injury: The CRASH-3 Trial.- Part V: Corticosteroids in Sepsis.- 29. Hydrocortisone-Fludrocortisone Combination in Septic Shock: Annane et al.- 30. Hydrocortisone in Septic Shock: The CORTICUS Trial.- 31. Hydrocortisone in Septic Shock: The ADRENAL Trial.- Part VI: Corticosteroids in ARDS.- 32. Methylprednisolone for Unresolving Acute Respiratory Distress Syndrome: Meduri et al.- 33. Corticosteroids in Persistent Acute Respiratory Distress Syndrome: The LAsRS Trial.- Part VII: Nephrology and Renal Replacement Therapy.- 34. Low-Dose Dopamine in Early Renal Dysfunction: The ANZICS Dopamine Trial.- 35. Continuous Venovenous Hemodiafiltration vs. Intermittent Hemodialysis for Acute Kidney Injury in the Critically Ill: The HEMODIAFE Trial.- 36. Timing of Renal Replacement Therapy in Critically Ill Patients with Acute Kidney Injury: The AKIKI Trial.- 37. Comparing Two Delayed Strategies for Renal Replacement Therapy Initiation in Severe Acute Kidney Injury: The AKIKI 2 Trial.- 38. Early vs. Late Initiation of Renal Replacement Therapy in Acute Kidney Injury: The ELAIN Trial.- 39. Timing of Renal Replacement Therapy in Septic Shock with Acute Kidney Injury: The IDEAL-ICU Trial.- 40. Timing of Initiation of Renal Replacement Therapy in Acute Kidney Injury: The STARRT-AKI Trial.- 41. Intensity of Renal Support in Critically Ill Patients with Acute Kidney Injury: The VA/NIH Trial.- Part VIII: Trauma.- 42. Immediate vs. Delayed Resuscitation in Penetrating Torso Injury: Bickell et al.- 43. Tranexamic Acid in Bleeding Trauma Patients: The CRASH-2 Trial.- Part IX: Extracorporeal Support.- 44. Extracorporeal Membrane Oxygenation in Acute Respiratory Failure: The CESAR Trial.- 45. Extracorporeal Membrane Oxygenation in Severe Acute Respiratory Distress Syndrome: The EOLIA Trial.- Part X: Infections.- 46. Duration of Antibiotic Therapy for Ventilator-Associated Pneumonia: The PNEUMA Trial.- 47. Duration of Hypotension Before Effective Antibiotic Therapy and Survival in Septic Shock: Kumar et al.- 48. Diagnostic Techniques for Ventilator-Associated Pneumonia: Canadian Critical Care Trials Group.- 49. Procalcitonin and Antibiotic Exposure in the ICU: The PRORATA Trial.- Part XI: Cardiology, Cardiac Surgery.- 50. Rate vs. Rhythm Control for Atrial Fibrillation Following Post-Cardiac Surgery: The CTSN Trial.- 51. Optimal PCI Strategy in Cardiogenic Shock Following Acute Myocardial Infarction: The CULPRIT-SHOCK Trial.- 52. Coronary Angioplasty vs. Fibrinolytic Therapy in Acute Myocardial Infarction: The DANAMI-2 Trial.- Part XII: Sepsis Resuscitation.- 53. Goal-Directed Resuscitation in Sepsis: The Rivers et al., ProCESS, ARISE, and ProMISe Trials.- 54. Dopamine vs. Norepinephrine in the Treatment of Shock: The SOAP II Trial.- 55. Vasopressin vs. Norepinephrine in Septic Shock: The VAAST Trial.- Part XIII: Nutrition.- 56. Early versus Late Parenteral Nutrition in the Critically Ill: The EPANIC Trial.- 57. Initial Trophic vs. Full Enteral Feeding in Acute Lung Injury: The EDEN Trial.- Part XIV: Therapeutic Hypothermia.- 58. Therapeutic Hypothermia After Out-of-Hospital Cardiac Arrest: The HACA Trial.- 59. Targeted Temperature Management After Cardiac Arrest: 33°C vs. 36°C: The TTM Trial.- 60. Hypothermia or Normothermia After Out-of-Hospital Cardiac Arrest? The TTM 2 Trial.- Part XV: Sedation in the ICU.- 61. Daily Interruption of Sedation in Mechanically Ventilated Patients: Kress et al.- 62. A Combined Sedation and Ventilator Weaning Protocol for Mechanically Ventilated Patients: The ABC Trial.- 63. No Sedation vs. Light Sedation in Mechanically Ventilated Patients: The NONSEDA Trial.- Part XVI: Pulmonary Embolism.- 64. Thrombolysis for Moderate Pulmonary Embolism: The MOPETT Trial.- 65. Fibrinolysis in Intermediate-Risk Pulmonary Embolism: The PEITHO Trial.- 66. Retrievable Inferior Vena Cava Filter Plus Anticoagulation vs. Anticoagulation Alone and Recurrent Pulmonary Embolism: The PREPIC2 Trial.- Part XVII: Glucose Control.- 67. Intensive vs. Conventional Glucose Control in the ICU: The NICE-SUGAR Trial.- 68. Intensive Insulin Therapy in the Surgical ICU: The Leuven 1 Trial.- 69. Intensive Insulin Therapy in the Medical ICU: The Leuven 2 Trial.- Part XVIII: Transfusion Thresholds.- 70. Transfusion Thresholds in the Critically Ill: The TRICC Trial.- 71. Transfusion Thresholds in Septic Shock: The TRISS Trial.- Part XIX: Covid-19 Pneumonia.- 72. Remdesivir for COVID-19 Pneumonia: The ACTT-1 Trial.- 73. Dexamethasone in COVID-19 Infection: The RECOVERY Trial.- Part XX: Miscellaneous.- 74. Acetaminophen for Fever in the Critically Ill: The HEAT Trial.- 75. Step-Up Approach vs. Open Necrosectomy for Acute Necrotizing Pancreatitis: The PANTER Trial.- 76. Intra-aortic Balloon Counterpulsation in Cardiogenic Shock Following Acute Myocardial Infarction: The IABP-SHOCK II Trial.- 77. Pulmonary Artery Catheter in the ICU: The PAC-Man Trial.- 78. Pharmacist Participation on ICU Rounds and Adverse Drug Events: Leape et al.