Kenneth Kee

Lynch Syndrome, A Simple Guide To The Condition, Diagnosis, Treatment And Related Conditions (eBook, ePUB)

• Format: ePub

Produktbeschreibung

Lynch syndrome is an inherited medical disorder that confers a person a higher risk of cancers of the digestive tract, gynecologic tract, and other organs.
In Singapore Lynch syndrome has an estimated incidence of 1 in 300 in women and 1 in 500 in the general population.
People who have Lynch syndrome have a considerably higher danger of forming:
1. Colorectal cancer (CRC),
2. Endometrial (uterine) cancer,
3. Gastric (stomach) cancer,
4. Ovarian cancer,
5. Small bowel (small intestinal) cancer,
6. Pancreatic cancer,
7. Urinary tract cancer (bladder or ureter cancer),
8. Kidney cancer,
9. Bile duct cancer,
10. Certain skin tumors (sebaceous tumors of the skin or sebaceous adenomas), and
11. Brain tumors.
People with Lynch syndrome may also be at slightly higher risk of:
1. Breast cancer and
2. Prostate cancer.
The old term for Lynch syndrome was "hereditary non-polyposis colorectal cancer" (HNPCC).
There is no likelihood toward polyp formation and hence the name HNPCC.
It is the most frequent genetic syndrome linked with a higher vulnerability to Colon cancer.
Patients with Lynch syndrome have a 60%-80% risk for Colorectal Cancer (CRC), as well as a higher risk for cancers, most conspicuously endometrial cancer
Endometrial cancer is the second most frequent malignancy in Lynch syndrome with a lifetime danger between 40% and 60%, often happening before Colorectal Cancer (CRC) in females.
The average age for colorectal cancer to be diagnosed in a person with Lynch syndrome is 45 in contrast with the average age of 72 for a new diagnosis of colorectal cancer in the general population.
In Lynch syndrome, colorectal cancer is rather more likely to form on the right side of the colon.
Cause:
Lynch syndrome is a genetic disorder, indicating that the cancer risk can be passed from generation to generation in a family.
Several genes have been identified that are linked to Lynch syndrome.
They are MLH1, MSH2, MSH6, PMS2, and EPCAM.
A mutation (modification) in any of these genes causes the person to have a higher lifetime danger of forming colorectal cancer and other related cancers.
Women also have a higher risk of forming endometrial and ovarian cancers.
Making the diagnosis of Lynch syndrome is normally a 3-stage process, such as:
1. Review of the family cancer history,
2. Tumor testing, and
3. Genetic testing
Lynch syndrome, autosomal dominant inheritance disorder, can also be established through a blood test.
The test can detect if someone has a mutation in one of the genes linked with Lynch syndrome.
Presently testing is provided for the MLH1, MSH2, MSH6, and EPCAM genes.
For patients who have a family history that indicates Lynch syndrome, screening tests can be done on tumor (cancer) tissue to help detect if Lynch syndrome is possible.
The two screening tests indicated are micro-satellite instability testing (MSI) and immuno-histo-chemistry testing (IHC).
The results of these tests can show whether more specific genetic testing should be done.
Treatment:
Removal of the entire colon is the only way to completely avoid the development of colon cancer or to treat a present colon cancer.
1. Subtotal colectomy with ileorectal anastomosis
2. Total colectomy with ileoanal pull-through (pouch procedure)
3. Total colectomy with ileostomy
Subtotal colectomy with ileo-rectal anastomosis and post-surgical rectal surveillance are advised when colorectal cancer forms in patients with Lynch Syndrome.
This surgery may be regarded for prevention in selected mismatch repair (MMR) gene mutation carriers.
Prognosis
The 5-year survival rate in patients with Lynch Syndrome is evaluated to be about 60%, compared with 40-50% for sporadic cases (normal colorectal cases).

TABLE OF CONTENT
Introduction
Chapter 1 Lynch Syndrome
Chapter 2 ...

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Produktdetails

• Verlag: Kenneth Kee
• Erscheinungstermin: 21. April 2017
• Englisch
• ISBN-13: 9781370751013
• Artikelnr.: 48183188

Autorenporträt

Dr. Kenneth Kee is a well-known medical doctor from Singapore who has been practicing medicine since 1972.
He graduated from the University of Singapore and furthered his studies with a Master of Science in Health Management in 1991, followed by a Ph.D. in Healthcare Administration in 1993.
Dr. Kee established Kee Clinic in 1974, located in the Holland Drive area of Singapore. The clinic has been a prominent feature of the community, offering general medical services for 5 decades.
Dr Kee also served his country Singapore as a national service police Inspector at night from 1975 to 1985 while working at his clinic during the day.
He had served as a police guard to the Woodland Petroleum Tanks at night during the Indonesian Confrontation period, took part in police rounds at night in the Beach Road area and taught First aid and emergency resuscitation to Police recruits.
He received the Singapore Police Bicentennial 2020 Medallion on 1st March 2024 as recognition for his work in the Singapore Police.
Even as he grew older, Dr. Kee continued to work actively in his clinic, although he eventually reduced his consultation hours.
Beyond his medical career, Dr. Kee is also an author.
He started writing about medical conditions in 2007, using blogs and other online platforms to share his knowledge with a broader audience.
Over time, he published various books, many of which provide simple and accessible guides to different health conditions.
His works include "A Family Doctor's Tale," "My Personal Singapore History," and numerous medical guides, available through platforms like Amazon.
His books often combine his personal experiences as a family doctor with insights into Singapore's healthcare system and history.
Dr. Kee has written extensively on health topics, contributing to both medical literature and general knowledge resources.

Dr. Kenneth Kee has written numerous books, primarily focused on health education and personal experiences as a family doctor. Some of his notable titles include:
"A Family Doctor's Tale"
This book is a blend of Dr. Kee's personal experiences and his reflections on being a family doctor in Singapore. It's a great choice if you're looking for a narrative that combines both medical knowledge and human stories.
"Specialized Medical Conditions"
Books like **"Congestive Heart Failure: Diagnosis and Treatment"** focus on specific conditions, offering in-dept...