Minimal Residual Disease and Circulating Tumor Cells in Breast Cancer (eBook, PDF)

Redaktion: Ignatiadis, Michail; Pantel, Klaus; Sotiriou, Christos

• Format: PDF

Produktbeschreibung

Provides up-to-date information on topical issues concerning minimal residual disease in breast cancer patients

Appraises the technologies available for detection and characterization of circulating and disseminated tumor cells (CTCs/DTCs)

Discusses the relevance of CTCs and DTCs in breast cancer clinical research and practice, and the role of other blood-based biomarkers

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Produktdetails

• Verlag: Springer Berlin Heidelberg
• Seitenzahl: 254
• Erscheinungstermin: 23. April 2012
• Englisch
• ISBN-13: 9783642281600
• Artikelnr.: 37373691

Inhaltsangabe

Minimal residual disease and circulating tumor cells in breast cancer: Open questions for research.- Minimal residual disease and breast cancer metastasis.- Self-seeding in cancer.- Microenvironments dictating tumor cell dormancy.- Technologies for circulating tumor cell (CTC) and disseminated tumor cell (DTC) detection and characterization.- Immunomagnetic separation technologies.- Microfluidic technologies for the isolation of CTCs.- EPISPOT assay: Detection of viable disseminating tumor cells in solid tumor patients.- Advances in optical technologies for rare cell detection and characterization.- Size-based enrichment technologies for circulating tumor cell (CTC) detection and characterization.- Emerging technologies for CTC detection based on depletion of normal cells.- Molecular assays for the detection and characterization of CTCs.- Multiplex molecular analysis of CTCs.- Other blood-based biomarkers.- Circulating DNA and next generation sequencing.- Circulating microRNAs as non-invasive biomarkers in breast cancer.- Circulating endothelial cells and circulating endothelial progenitors.- Disseminated tumor cells (DTCs) and circulating tumor cells (CTCs) in breast cancer clinical research and practice.- Bone marrow DTCs.- CTCs in primary breast cancer.- CTCs in early breast cancer.- CTCs in metastatic breast cancer.- HER2-positive DTCs/CTCs in breast cancer.- DTCs and CTCs in breast cancer - 5 decades later.- Drug and circulating tumor cell co-development.- Challenges in drug and biomarker co-development.- Challenges and opportunities in the use of CTCs for companion diagnostic development.

Rezensionen

From the reviews:

"This book is aimed directly at cancer researchers, delving into the various technologies used to identify and characterize these rare tumor cells. ... this is the first book to summarize the progress in this field. It charts the evolution in thinking about breast cancer from the Halstedian notion of a local disease to more of a systemic illness in an accessible way and nicely summarizes the data without overwhelming readers." -- Megan E. Sullivan, Doody's Review Service, July, 2012