Modern Adaptive Randomized Clinical Trials (eBook, PDF)

Statistical and Practical Aspects
Redaktion: Sverdlov, Oleksandr

• Format: PDF

Produktbeschreibung

Is adaptive randomization always better than traditional fixed-schedule randomization? Which procedures should be used and under which circumstances? What special considerations are required for adaptive randomized trials? What kind of statistical inference should be used to achieve valid and unbiased treatment comparisons following adaptive random

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Produktdetails

• Verlag: Taylor & Francis eBooks
• Seitenzahl: 533
• Erscheinungstermin: 30. Juni 2015
• Englisch
• ISBN-13: 9781482239898
• Artikelnr.: 43588204

Autorenporträt

Oleksandr Sverdlov

Inhaltsangabe

An Overview of Adaptive Randomization Designs in Clinical Trials. Efron's
Biased Coin Design Revisited: Statistical Properties, Randomization-Based
Inference, and Sequential Monitoring. Adaptive Biased Coins: Achieving
Better Balance without Compromising Randomness. Brick Tunnel and Wide Brick
Tunnel Randomization for Studies with Unequal Allocation. Development of
Novel Covariate-Adaptive Randomization Designs. Optimal Model-Based
Covariate-Adaptive Randomization Designs. Statistical Inference Following
Covariate-Adaptive Randomisation: Recent Advances. Covariate-Adaptive
Randomization with Unequal Allocation. Optimal Allocation Designs for a
Multi-Arm Multi-Objective Clinical Trial. Response-Adaptive Randomization:
An Overview of Designs and Asymptotic Theory. Statistical Inference
Following Response-Adaptive Randomization. Sample Size Re-Estimation in
Adaptively Randomized Clinical Trials with Missing Data. Some Caveats for
Outcome Adaptive Randomization in Clinical Trials. Efficient and Ethical
Adaptive Clinical Trial Designs to Detect Treatment-Covariate Interaction.
Longitudinal Covariate-Adjusted Response-Adaptive Randomization: Impact of
Missing Data. Targeted Covariate-Adjusted Response-Adaptive LASSO-Based
Randomized Controlled Trials. Covariate-Balanced Bayesian Adaptive
Randomization: Achieving Tradeoff Between Inferential and Ethical Goals in
Small and Moderate Size Trials. Multi-Arm Multi-Stage Designs for Clinical
Trials with Treatment Selection. Sequential Elimination in Multi-Arm
Selection Trials. Accounting for Parameter Uncertainty in Two-Stage Designs
for Phase II Dose-Response Studies. A Single Pivotal Adaptive Trial in
Infants with Proliferating Hemangioma: Rationale, Design Challenges,
Experience, and Recommendations. Practical Implementation of Dose-Response
Adaptive Trials. Statistical Monitoring of Data in Response-Adaptive
Randomized Clinical Trials.