Shankar Vallabhajosula

Molecular Imaging and Targeted Therapy (eBook, PDF)

Radiopharmaceuticals and Clinical Applications

• Format: PDF

Produktbeschreibung

This book, now published in its second edition, covers a wide range of topics relating to the use of radiopharmaceuticals. The basics of nuclear chemistry, radiochemistry, and radiopharmacology are considered in detail, regulatory issues are reviewed, and potential applications in drug development, translational medicine, clinical diagnostics, and targeted therapy are discussed. Compared with the first edition, the chapters on targeted therapy with alpha- and beta-emitting radiopharmaceuticals and theranostics are completely new. Other chapters have been updated and revised as necessary.

Radioisotope-based molecular imaging probes (radiopharmaceuticals) provide unprecedented insights into biochemistry and function in both normal and diseased states of living systems, with unbiased in vivo measurements of regional radiotracer activities offering very high specificity and sensitivity. No other molecular imaging technology, including functional magnetic resonance imaging, can provide such high sensitivity and specificity at a tracer level. This book, written by an experienced radiochemist and scientist, offers valuable insights into the full range of applications of this technology.

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Produktdetails

• Verlag: Springer International Publishing
• Seitenzahl: 708
• Erscheinungstermin: 31. März 2023
• Englisch
• ISBN-13: 9783031232053
• Artikelnr.: 67712354

Autorenporträt

Dr. Vallabhajosula attended high school in the small town of Bobbili, Andhra Pradesh, India. He graduated from Andhra University with a BS and MS in Pharmacy and subsequently obtained his Ph.D. from the University of Southern California, in 1980. After receiving the doctorate, he first worked at Mount Sinai Medical Center in New York and since 1997 has been a Professor of Radiochemistry and Radiopharmacy in Radiology at Weill Cornell Medicine of Cornell University and New York Presbyterian Hospital. He is now the Professor Emeritus in Radiology at Weill Cornell Medicine.

Inhaltsangabe

Molecular Imaging and Targeted Therapy: Introduction.- Atomism and Radioactivity: A Brief History.- Atoms and Radiation.- Radioactivity.- Production of Radionuclides.- PET and SPECT Scanners.- Chemistry: Basic Principles.- Cell and Molecular Biology.- Radiopharmaceuticals.- Chemistry of Organic Radionuclides (C, N, and O).- Chemistry of Radiohalogens (F, Br, I, and At).- Chemistry of Trivalent Metals Radionuclides (Ga, In, Y, Lu).- Chemistry of Transition Metals (Cu, Zr, Tc, Re).- Quality Control of Radiopharmaceuticals.- Pharmacokinetics and Modeling.- Molecular Imaging in Oncology.- Molecular Imaging in Neurology and Psychiatry.- Molecular Imaging in Cardiology.- Molecular Imaging of Gene Expression and Cell Trafficking.- Radiation Dosimetry and Protection.- Radiopharmaceuticals for Targeted Therapy.- Targeted Therapy with Beta Emitting Radiopharmaceuticals.- Targeted Therapy with Alpha Emitting Radiopharmaceuticals.- Theranostics: Molecular Imaging and Targeted Therapy.- Radiopharmaceuticals: Drug Development and Regulatory Issues.