Muscle Metabolism (eBook, PDF)

Redaktion: Zierath, Juleen R; Wallberg-Henrikss, Harriet

• Format: PDF

Produktbeschreibung

Diabetes research on models comprising intact animal tissues, cell cultures and isolated pancreatic islets is essential for understanding the pathogenesis of the disease as well as the mechanisms responsible for the chronic complications associated with it. Enormous advances in the understanding of the development of diabetes and its prevention hav

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Produktdetails

• Verlag: Taylor & Francis eBooks
• Seitenzahl: 460
• Erscheinungstermin: 28. Februar 2002
• Englisch
• ISBN-13: 9781134485420
• Artikelnr.: 57541641

Autorenporträt

Juleen R Zierath, Harriet Wallberg-Henrikss

Inhaltsangabe

Insulin Signaling. Overview: Tyrosine Kinase Signaling in Insulin Action.
Defects in Early Insulin Signaling in Skeletal Muscle. Defects in
Intermediate Insulin Signaling in Skeletal Muscle: (PI) 3-kinase and
Glucose Transport. Glucose Transport. Glucose Transport in Muscle. The
GLUT4 Compartments of Skeletal Muscle. Substrate Utilization. Adverse
Metabolic Consequences of Hyperglycemia ("Glucose Toxicity"): Implications
for the Pathogenesis of Diabetes Mellitus. Cellular Mediators of
Glucose-Induced Autoregulation of Hexose Transport. Physiological
Adaptations in Glucose Utilization of Skeletal Muscle. Fatty Acids and
Muscle Insulin Resistance. Role of AMP Kinase and Malonyl CoA in
Exercise-stimulated Skeletal Muscle Metabolism and Insulin Action.
Transgenic and Genetic Models. The Use of Mouse Transgenic and Homologous
Recombination Technologies to Analyze the Physiologic Basis of Glucose
Homeostasis. Transgenic Approaches to Insulin Signaling. Transgenic Models
to Study Glucose Transport and Metabolism in Skeletal Muscle. Diabetic
Animals. Insulin Resistance in Skeletal Muscle: a Role for Impaired Insulin
Activation of Glycogen Synthase. Muscle GLUT4 Traffic and Insulin Resistant
States. Glucose Transport in Heart: Special Emphasis on Insulin Resistance
and NIDM. Cellular Redox State and Insulin Sensitivity: Potential Role of
Lipoic Acid. Exercise and Aging. Exercise Training and Muscle Insulin
Resistance: Cellular Adaptations. Effects of Physical Exercise on the
Decreased Insulin Action Caused by Aging. Effects of Aging on Glucose
Homeostasis: Cellular Approaches. Application to Humans. Insulin
Resistance: Whole Body Mechanisms in Humans. Cellular Mechanisms.