Mutagenicity: Assays and Applications (eBook, ePUB)

Redaktion: Kumar, Ashutosh; Shanker, Rishi; Dhawan, Alok; Dobrovolsky, Vasily N.

• Format: ePub

Produktbeschreibung

Mutagenicity: Assays and Applications presents an extensive examination of the detection, assessment and future of mutagenicity, particularly as it concerns human health and the environment. Chapters focused on specific types of mutagens or testing methods for their detection collectively explore the current state of human and environmental mutagenesis, future perspectives and regulatory needs. The test procedures for measuring mutagenicity, their advantages and limitations are described with practical and procedural detail, along with their presentation and data processing aspects. It is an essential reference covering the breadth and depth of the field of mutagenicity studies and regulation.

By providing both important introductory material and practical assays and applications, this book is useful to graduate students, academic and industry researchers and regulators at various stages of their careers, leading to improved risk assessment and regulation.

• Presents an up-to-date and in-depth review of the current state of mutagenesis research
• Draws upon the combined experience and expertise of an international group of highly respected editors and chapter authors
• Provides an introduction to the concept of mutagenesis with particular consideration given to novel chemicals and materials

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Produktdetails

• Verlag: Elsevier Science & Techn.
• Seitenzahl: 350
• Erscheinungstermin: 26. September 2017
• Englisch
• ISBN-13: 9780128092606
• Artikelnr.: 49252795

Autorenporträt

Ashutosh Kumar works as an Assistant Professor in the Division of Biological and Life Sciences, School of Arts and Sciences, Ahmedabad University, Gujarat, India. He obtained his Master's degree in Applied Microbiology from Vellore Institute of Technology, Vellore in 2008 and worked at CSIR-Indian Institute of Toxicology Research, Lucknow for his Doctorate degree and was involved in understanding the fate of nanomaterials on biological systems. His current research areas of interest includes, nanomedicines for cancer and arthritis therapy, DNA Biochip for pathogen detection, nanobased drug and gene delivery, nanoemulsions for food industries, environmental nanotechnology and nanotoxicology.

Ashutosh has established several new methods for nanomaterial toxicology in India. He developed a novel method for the detection of uptake of nanoparticles in live bacteria for several generations. He also unravelled the mechanism of metal oxide nanoparticles induced genotoxicity and apo

ptosis in prokaryotic as well as in eukaryotic cells using the state of art techniques such as flow cytometry, electron and confocal microscopy, biochemical enzyme assays, genomics and proteomics. The work conducted by him is in the frontiers of nanomaterial safety area worldwide. His studies shall have far reaching applications in predicting the adverse health effects of nanoparticles and safe use of ENMs to protect human and environmental health.

He has published more than 40 research papers and 12 book chapters in internationally reputed peer reviewed journals. He has received several national and international awards including the "INSA Medal For Young Scientist 2014? in the area of Health Sciences, NASI-Young Scientist Platinum Jubilee Award (2015) in the field of Bio-medical, Molecular Biology and Bio-technology, DBT Young Investigator Award, Ahmedabad University - Excellence in Research Award - 2015, among others for his scientific contributions.

Inhaltsangabe

1. Mutagenesis and health problems
2. Molecular mechanisms of mutagenesis
3. Bacterial mutation assays
4. Gene mutation assays in cultured mammalian cells
5. Chromosomal aberration test
6. In vivo cytogenetic assay
7. Mutagenicity testing in environmental pollution control
8. Mutagens in food and water
9. Emerging methods for the identification of mutagens
10. Guidelines and registration of the new compounds or drug like molecules
11. Mutagenicity testing, regulatory guidelines and current needs