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This book unites the diverse range of complex neurodegenerative diseases into a textbook designed for clinical practice, edited by globally leading authorities on the subject. Presents a clinically oriented guide to the diseases caused by neurodegeneration | Templated chapters combine clinical and research information on neurodegenerative diseases beginning with the common elements before treating each disease individually | Diseases are grouped by anatomical regions of degeneration and include common disorders such as Parkinson's Disease, Alzheimer's Disease, Amyotrophic Lateral…mehr
This book unites the diverse range of complex neurodegenerative diseases into a textbook designed for clinical practice, edited by globally leading authorities on the subject.
Presents a clinically oriented guide to the diseases caused by neurodegeneration
Templated chapters combine clinical and research information on neurodegenerative diseases beginning with the common elements before treating each disease individually
Diseases are grouped by anatomical regions of degeneration and include common disorders such as Parkinson's Disease, Alzheimer's Disease, Amyotrophic Lateral Sclerosis/Motor Neuron Disease, and Multiple Sclerosis as well as less common diseases
Edited by globally leading authorities on the subject, and written by expert contributing authors
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Autorenporträt
About the Editors Professor Anthony Schapira is Professor of Neurological Science and Head of the Department of Clinical Neuroscience at the UCL Institute of Neurology, London, UK and Chairman of Clinical Neurosciences Specialties. Zbigniew Wszolek, MD, is Professor of Neurology in the Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA. Ted M.Dawson, MD, PhD, is Leonard and Madlyn Abramson Professor of Neurodegenerative Diseases and Scientific Director in the Institute for Cell Engineering, Johns Hopkins University, Baltimore, Maryland, USA. Professor Nicholas Wood is Research Director of the UCL Institute of Genetics and Galton Professor of Genetics at UCL National Hospital for Neurology and Neurosurgery, Institute of Neurology, London, UK.
Inhaltsangabe
List of Contributors, vi Preface, ix Dedication, x 1 Pathology of Brain Aging, 1 Janna H. Neltner and Peter T. Nelson 2 Protein Aggregation and Neurodegeneration: Tauopathies and Synucleinopathies, 12 Michel Goedert 3 Prion Degeneration, 25 James A. Mastrianni 4 Excitotoxicity, 37 Mark P. Mattson 5 Etiology and Pathogenesis of Parkinson Disease, 46 Ruth-Mary deSouza and Anthony H.V. Schapira 6 Parkinson Disease: Treatment Options - Surgical Therapy, 53 Travis S. Tierney and Andres M. Lozano 7 Multiple System Atrophy: Clinical, Genetics, and Neuropathology, 58 Lucia V. Schottlaender, Anna Sailer, Zeshan Ahmed, Dennis W. Dickson, Henry Houlden, and Owen A. Ross 8 Progressive Supranuclear Palsy, 72 Huw R. Morris 9 Dementia with Lewy Bodies, 83 Rodolfo Savica and David S. Knopman 10 Corticobasal Degeneration, 93 Keith A. Josephs, Jr. 11 Alzheimer's Disease, 102 Qurat ul Ain Khan and Neill R. Graff-Radford 12 Frontotemporal Dementia, 115 Christian W. Wider, Barbara Jasinska-Myga, Takuya Konno, and Zbigniew K. Wszolek 13 Prion Diseases and Other Rapidly Progressive Dementias, 126 Eric Eggenberger and Daniel L. Murman 14 Amyotrophic Lateral Sclerosis and Primary Lateral Sclerosis, 137 Kevin B. Boylan, Mark A. Ross, and Eric J. Sorenson 15 Hereditary Spastic Paraplegia, 161 Pawel P. Liberski and Craig Blackstone 16 Spinal Muscular Atrophy, 179 Joseph R. Wooley, Melissa E. Crowder, Noah J. Pyles, and Charlotte J. Sumner 17 Spinal and Bulbar Muscular Atrophy (Kennedy Disease), 202 Erich Peter Bosch 18 Optic Neuropathies, 211 Desmond Kidd 19 Peripheral Nerve Neuropathies Including Charcot-Marie-Tooth Disease, 218 Amelie Pandraud and Henry Houlden 20 Axonal Loss and Neurodegeneration in Multiple Sclerosis, 238 Ranjan Dutta, Jacqueline Chen, Nobuhiko Ohno, Daniel Ontaneda, and Bruce D. Trapp 21 Huntington's Disease and Other Choreas, 248 Salman Haider, Edward Wild, and Sarah J. Tabrizi 22 Spinocerebellar Ataxias, 284 H. Brent Clark and Harry T. Orr 23 Ataxia Telangiectasia, 296 Malcolm Taylor 24 Niemann-Pick Disease, 303 Marc C. Patterson 25 X-linked Adrenoleukodystrophy, 309 Deborah L. Renaud 26 Neurodegeneration with Brain Iron Accumulation, Wilson Disease, and Manganism, 317 Alisdair McNeill Index, 327
List of Contributors, vi Preface, ix Dedication, x 1 Pathology of Brain Aging, 1 Janna H. Neltner and Peter T. Nelson 2 Protein Aggregation and Neurodegeneration: Tauopathies and Synucleinopathies, 12 Michel Goedert 3 Prion Degeneration, 25 James A. Mastrianni 4 Excitotoxicity, 37 Mark P. Mattson 5 Etiology and Pathogenesis of Parkinson Disease, 46 Ruth-Mary deSouza and Anthony H.V. Schapira 6 Parkinson Disease: Treatment Options - Surgical Therapy, 53 Travis S. Tierney and Andres M. Lozano 7 Multiple System Atrophy: Clinical, Genetics, and Neuropathology, 58 Lucia V. Schottlaender, Anna Sailer, Zeshan Ahmed, Dennis W. Dickson, Henry Houlden, and Owen A. Ross 8 Progressive Supranuclear Palsy, 72 Huw R. Morris 9 Dementia with Lewy Bodies, 83 Rodolfo Savica and David S. Knopman 10 Corticobasal Degeneration, 93 Keith A. Josephs, Jr. 11 Alzheimer's Disease, 102 Qurat ul Ain Khan and Neill R. Graff-Radford 12 Frontotemporal Dementia, 115 Christian W. Wider, Barbara Jasinska-Myga, Takuya Konno, and Zbigniew K. Wszolek 13 Prion Diseases and Other Rapidly Progressive Dementias, 126 Eric Eggenberger and Daniel L. Murman 14 Amyotrophic Lateral Sclerosis and Primary Lateral Sclerosis, 137 Kevin B. Boylan, Mark A. Ross, and Eric J. Sorenson 15 Hereditary Spastic Paraplegia, 161 Pawel P. Liberski and Craig Blackstone 16 Spinal Muscular Atrophy, 179 Joseph R. Wooley, Melissa E. Crowder, Noah J. Pyles, and Charlotte J. Sumner 17 Spinal and Bulbar Muscular Atrophy (Kennedy Disease), 202 Erich Peter Bosch 18 Optic Neuropathies, 211 Desmond Kidd 19 Peripheral Nerve Neuropathies Including Charcot-Marie-Tooth Disease, 218 Amelie Pandraud and Henry Houlden 20 Axonal Loss and Neurodegeneration in Multiple Sclerosis, 238 Ranjan Dutta, Jacqueline Chen, Nobuhiko Ohno, Daniel Ontaneda, and Bruce D. Trapp 21 Huntington's Disease and Other Choreas, 248 Salman Haider, Edward Wild, and Sarah J. Tabrizi 22 Spinocerebellar Ataxias, 284 H. Brent Clark and Harry T. Orr 23 Ataxia Telangiectasia, 296 Malcolm Taylor 24 Niemann-Pick Disease, 303 Marc C. Patterson 25 X-linked Adrenoleukodystrophy, 309 Deborah L. Renaud 26 Neurodegeneration with Brain Iron Accumulation, Wilson Disease, and Manganism, 317 Alisdair McNeill Index, 327
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