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Autorenporträt
Dr. Aschner serves as the Harold and Muriel Block Chair in Molecular Pharmacology at Albert Einstein College of Medicine. He served on numerous toxicology panels (Institute of Medicine, US Environmental Protection Agency, Center for Disease Control), and is a member of the Neurotoxicology and Alcohol study section (NIH). Research in our lab focuses on the following topics: (1) Modulation of C. elegans genes (aat, skn-1, daf-16) that are homologous to mammalian regulators of MeHg uptake and cellular resistance will modify dopaminergic neurodegeneration in response to MeHg exposure. (2) Under conditions of MeHg-induced oxidative stress, Nrf2 (a master regulator of antioxidant responses) coordinates the upregulation of cytoprotective genes that combat MeHg-induced oxidative injury, and that genetic and biochemical changes that negatively impact upon Nrf2 function increase MeHg's neurotoxicity. (3) PARK2, a strong PD genetic risk factor, alters neuronal vulnerability to modifiers of
cellular Mn status, particularly at the level of mitochondrial dysfunction and oxidative stress. Our studies are designed to (1) shed novel mechanistic insight into metal-induced neurodegeneration; (2) identify targets for genetic or pharmacologic modulation of neurodegenerative disorders; (3) increase knowledge of the pathway involved in oxidative stress; (4) develop improved research models for human disease using knowledge of environmental sciences.
Inhaltsangabe
1. Molecular mechanisms of aluminum neurotoxicity: Update on adverse effects and therapeutic strategies
Anatoly V. Skalny, Michael Aschner, Yueming Jiang , Yordanka G. Gluhcheva, Yousef Tizabi, Ryszard Lobinski and Alexey A. Tinkov
2. Arsenic-mediated developmental neurotoxicity: Recent advances in understanding the adverse outcomes and underlying mechanisms
Stefan Masjosthusmann, Julia Tigges, Ellen Fritsche and Katharina Koch
3. Cadmium neurotoxicity: From its analytical aspects to neuronal impairment
Jamile Fabbrin Gonçalves, Valderi Luiz Dressler, Charles Elias Assmann, Vera Maria Melchiors Morsch and Maria Rosa Chitolina Schetinger
4. Neurotoxicity of copper and copper nanoparticles
Arundhati Joshi, Kathrin Farber and Ivo F. Scheiber
5. Molecular mechanisms of lead neurotoxicity
Miriam B. Virgolini and Michael Aschner
6. Neurotoxicity mechanisms of manganese in the central nervous system
Edward Pajarillo, Ivan Nyarko-Danquah, Getinet Adinew, Asha Rizor, Michael Aschner and Eunsook Lee
7. Neurotoxicity of mercury: An old issue with contemporary significance
Vasco Branco, Michael Aschner and Cristina Carvalho
8. Neurotoxicity of nickel
Omamuyovwi M. Ijomone
9. Neurotoxicity of thallium: Old issues and new developments
Laura Osorio-Rico, Abel Santamaría, Syed F. Ali and Sonia Galván-Arzate
10. Neurotoxicity of vanadium
FA Olaolorun, FE Olopade, IL Usende, AD Lijoka, AD Ladagu and JO Olopade
11. Neurotoxicity of metal mixtures
Lopes de Andrade, Vanda, Marreilha dos Santos, Ana Paula and Aschner, Michael
