Nuclear Receptors in Development (eBook, PDF)

• Format: PDF

Produktbeschreibung

A superb compilation of reviews from leading experts in the field of nuclear receptors, volume 16 in the Advances in Developmental Biology series covers the role of different nuclear receptor subfamilies in development, physiology and metabolism. This volume brilliantly reviews how genetic defects in the function of nuclear receptors leads to various developmental defects. Receptors discussed include: thyroid receptors, peroxisome proliferators activated receptors, and retinoic acid receptors. Additionaly, this volume offers an indespesable chapter on the orphan receptors Ftz-F1, COUPs, and RORs in embryonic and postnatal development.* Provides a compilation of reviews of several nuclear receptor subfamilies - such as TRs, PPARs, RARs, the orphan receptors COUP-TFs, RORs, and Ftz-F1 in embryonic and postnatal development.* Offers a detailed section on retinoid receptor signaling * Covers the role of co-repressors and co-activators in modulation of nuclear receptor functions

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Produktdetails

• Verlag: Elsevier Science & Techn.
• Seitenzahl: 448
• Erscheinungstermin: 7. November 2006
• Englisch
• ISBN-13: 9780080469409
• Artikelnr.: 38113783

Autorenporträt

Paul M. Wassarman, the Series Editor of CTDB since 2007, is Professor in the Dept. Developmental and Regenerative Biology at the Icahn School of Medicine at Mount Sinai in New York City. He received a Ph.D. in biochemistry from Brandeis University where he carried out thesis research in the Graduate Dept. Biochemistry with Professor Nathan O. Kaplan. In 1967 Wassarman joined the Division of Structural Studies at the MRC, Laboratory of Molecular Biology in Cambridge, England as a Helen Hay Whitney Foundation Fellow with Sir John C. Kendrew. In 1972 he joined the faculty of the Dept. Biological Chemistry at Harvard Medical School and in 1986 moved to the Roche Institute of Molecular Biology where he was Chair of the Dept. Cell and Developmental Biology and Adjunct Professor in the Dept. Cell Biology, New York University School of Medicine. In 1996 he moved to the Icahn School of Medicine at Mount Sinai where he was the Lillian and Henry M. Stratton Professorial Chair of the Dep

t. Molecular, Cell, and Developmental Biology. Wassarman has published more than 200 research papers and reviews, dealing primarily with mammalian oogenesis, fertilization, and early embryogenesis.

Inhaltsangabe

1. Developmental Roles of the Thyroid Hormone Receptor Á And  Genes

2. PPARs in fetal and early post-natal development

3. Regulation of murine embryonic patterning and morphogenesis by retinoic acid signaling

4. Molecular mediators of retinoic acid signalling during development

5. Hindbrain development and retinoids

6. Retinoid receptors in vertebral patterning

7. Mouse Embryocarcinoma F9 cells and Retinoic Acid: A model to study the molecular mechanisms of endodermal differentiation

8. The Ftz-F1 family: orphan nuclear receptors regulated by novel protein-protein interactions

9. Role of Chicken Ovalbumin Upstream Promoter-Transcription Factor I in the Development of Nervous System

10. Retinoid-related Orphan Receptors (RORs): Roles in Cellular Differentiation and Development

11. Hairless, a nuclear receptor corepressor essential for skin function

12. Nuclear receptor transcriptional coactivators in development and metabolism