Organ-on-a-chip (eBook, ePUB)

Engineered Microenvironments for Safety and Efficacy Testing
Redaktion: Hoeng, Julia; Peitsch, Manuel C.; Bovard, David

• Format: ePub

Produktbeschreibung

Organ-on-a-Chip: Engineered Microenvironments for Safety and Efficacy Testing contains chapters from world-leading researchers in the field of organ on a chip development and applications, with perspectives from life sciences, medicine, physiology and engineering. The book contains an overview of the field, with sections covering the major organ systems and currently available technologies, platforms and methods. As readers may also be interested in creating biochips, materials and engineering best practice, these topics are also described. Users will learn about the limitations of 2D in-vitro models and the available 3D in-vitro models (what benefits they offer and some examples). Finally, the MOC section shows how the organ on a chip technology can be adapted to improve the physiology of in-vitro models. - Includes case studies of other organs on a chip that have been developed and successfully used - Provides insights into functional microphysiological organ on a chip platforms for toxicity and efficacy testing, along with opportunities for translational medicine - Presented fields (PK/PD, physiology, medicine, safety) are given a definition followed by the challenges and potential of organs on a chip

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Produktdetails

• Verlag: Elsevier Science & Techn.
• Seitenzahl: 546
• Erscheinungstermin: 9. November 2019
• Englisch
• ISBN-13: 9780128172032
• Artikelnr.: 61688883

Autorenporträt

Dr. Hoeng is Director of Systems Biology at Phillip Morris International and program leader. She has a profound understanding of inhalation toxicology and computational modeling of smoking-related diseases, lung cancer, COPD, and CVD. Dr. Hoeng holds a BSc in biology, MSc in bioinformatics, PhD in protein crystallography, and an executive MBA.

Inhaltsangabe

1. Need for alternative testing methods and opportunities for organ-on-a-chip systems
2. Cell sources and methods for producing organotypic in vitro human tissue models
3. Organs-on-a-chip engineering

Part I Organ-on-a-chip platforms to model disease pathogenesis
4. Lung-on-a-chip platforms for modeling disease pathogenesis
5. Requirements for designing organ-on-a-chip platforms to model the pathogenesis of liver disease
6. Brain-on-a-chip systems for modeling disease pathogenesis
7. Kidney-on-a-chip
8. Heart-on-a-chip
9. Caenorhabditis elegans-on-a-chip: microfluidic platforms for high-resolution imaging and phenotyping
10. Gut-on-a-chip microphysiological systems for the recapitulation of the gut microenvironment
11. Computational pharmacokinetic modeling of organ-on-chip devices and microphysiological systems

Part II Multi-organs-on-a-chip platforms to mimic humans physiology
12. Design and engineering of multiorgan systems
13. 8.b. Human body-on-a-chip systems
14. Automation and opportunities for industry scale-up of microphysiological systems
15. How to build your multiorgan-on-a-chip system: a case study

Rezensionen

"As a carnivore, when reading this text, I wondered if lessons learned from current attempts to "grow? meat could be applied to some of the work herein. (See, for example, "The race to make cell grown meats mainstream,? Popular Mechanics, July/August 2020, pp. 44-51.) As a (retired) design instructor, having had the experience of having had students working on organ-on-a-chip devices for their senior projects, I find this book to be very up to date and a good overview of the field. As a reviewer, I recommend this text for use in introducing new investigators and entrepreneurs to this field of applied work in physiology and toxicology." --IEEE EMBS PULSE Magazine