Francesco Chiappelli

Osteoimmunopathology (eBook, PDF)

Evidence-Based Perspectives from Molecular Biology to Systems Biology

• Format: PDF

Produktbeschreibung

Osteoimmunology pertains to the study of the relationship between the bones, particularly the bone marrow, and the immune system. This monograph pursues the best available evidence, by means of research synthesis, for the characterization of the physiological relevance and pathological implications of the inter-connectedness between the skeletal and the immune system. Research will be discussed that highlights the associated role of the circulatory, nervous and endocrine systems, as well as proteomic and genomic pathways and signatures. Emphasis is given that domain of medicine that relates to the oral cavity, its diseases and their systemic sequelae. This monograph arises from observations that have suggested that the skeletal system and the immune system are intimately intertwined. Chronic inflammatory reactions subsequent to an excessive immune reaction can damage the bones, as in rheumatoid arthritis (RA), osteoporosis, patients seropositive for the human immunodeficiency virus (HIV)-1 and with signs and symptoms of the acquired immune deficiency syndrome (AIDS), and bone cancer. Bones - in particular the bone marrow - are one of the primary locations in which cells of the immune system mature. In brief, this monograph begins to answer a range of questions, such as, what is osteoimmunology all about?, does the immune system and its components affect bone development?, how do stress hormones impact upon the pathophysiology of bone-immune interactions?, can the scientific process of research synthesis, obtain the best available evidence for treatment of diseases involving the bone-immune entity (i.e., osteo immunopathologies) means of evidence-based clinical decision-making directed at the treatment of osteoimmune pathologies?

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Produktdetails

• Verlag: Springer US
• Seitenzahl: 137
• Erscheinungstermin: 30. Mai 2011
• Englisch
• ISBN-13: 9781441994950
• Artikelnr.: 37353368

Autorenporträt

Professor Francesco Chiappelli, Ph.D. has contributed extensively to the development of the field of evidence-based and comparative effectiveness decision-making in health care over the past several years through his teaching, research publications, and authorship of several book chapters and books. Professor Chiappelli is the founder and director of the International Forum on evidence-based decisions and comparative effectiveness research (IF-EBD-CER), and is the honorary president of the Brazilian Association for Evidence-based dentistry. He is a American Dental Association Champion of evidence-based dentistry, and he is listed as a Fulbright Specialists for his expertise in evidence-based and comparative effectiveness analysis in health care.

Inhaltsangabe

Part 1: Fundamentals.- Osteoimmunology: Introduction to a new field.- Immunobiology.- Bone metabolism.- The Osteoimmune system: RANK-RANKL (et all).- Part II: Clinical & Translational Research.- Clinical & Translational research - Fundamental Principles.- Evidence-Based Research in Osteoimmunology.- Evidence-Based Clinical Osteoimmune Practice.- Special population * Problems-Based Osteoimmunology.- Part III: Challenges for the Future.- Biomarkers.- Epigenetic and Chromatin Regulation in Osteoimmune Regulation.- Stem Cells Niches and Osteoimmune Microenvironments.- Techniques & Protocols.-