Tongshuang Li

Overcoming Synthetic Challenges in Medicinal Chemistry (eBook, ePUB)

Mechanistic Insights and Solutions

• Format: ePub

Produktbeschreibung

Collection of 150 synthetic problems in medicinal chemistry offering mechanistic insights into complex reactions and potential pitfalls in drug synthesis

Overcoming Synthetic Challenges in Medicinal Chemistry is a comprehensive collection of around 150 challenging organic reactions in medicinal chemistry, drawn from the author's work experience and recent journal and patent publications. Problems are arranged by the structure of the reaction product to make it easier for the reader to find the information needed.

In this book, readers will find information on:

• General terms and concepts in synthetic organic chemistry and medicinal chemistry
• Specific reactions leading to desired products or unexpected side products
• Step-by-step mechanisms, experimental procedures, literature information, and applications for each reaction
• Ways to reduce mistakes in synthetic work and optimize product synthesis

Overcoming Synthetic Challenges in Medicinal Chemistry serves as a valuable guide for organic chemists, professionals, and job candidates in the pharmaceutical industry, as well as graduates and lecturers at university, helping them grasp complex reactions and gain insight into potential pitfalls and side reactions in drug synthesis.

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Produktdetails

• Verlag: Wiley-VCH
• Seitenzahl: 720
• Erscheinungstermin: 10. September 2025
• Englisch
• ISBN-13: 9783527852628
• Artikelnr.: 75429852

Autorenporträt

Tongshuang Li has extensive experience in synthetic organic chemistry and medicinal chemistry, with over 22 years in the pharmaceutical industry and 12 years in academia. Currently, he is working as a chemistry consultant for both biotech companies and academics. Dr. Li's work primarily focuses on the synthesis of target compounds for drug discovery, with two new drugs recently approved in China.

Inhaltsangabe

Preface
Abbreviations
CHAPTER 1 OPINIONS AND SUGGESTIONS
1.1 Be a "doctor", not just be a "drug fetcher"
1.2 One a large degree, synthetic organic chemistry is still an art
1.3 Synthetic organic chemistry is an experimental science under the guidance of theory
1.4 Reduce your mistakes in your synthetic work
1.5 Your knowledge, experience, and skills never be too much
1.6 What is a mistake?
1.7 With your own ideas when you search references
1.8 Improve your decision-making ability
1.9 Knowing the mechanism of the reactions you are doing
1.10 Always learn something from the reaction you performed
1.11 Knowing reaction mechanism is not sufficient to be an excellent chemist, but it is a necessary
1.12 Patents do not tell you the full story of chemistry
1.13 Write a summary when complete a synthesis
1.14 Two examples

CHAPTER 2 GENERAL TERMS AND CONCEPTS IN SYNTHETIC ORGANIC CHEMISTRY
2.1 Reaction mechanism
2.2 The approaches to draw reaction mechanism
2.3 Desired product
2.4 Unexpected product
2.5 Side reaction
2.6 Side product and by-product
2.7 Impurity
2.8 Theoretical yield, percentage yield (yield), net yield, and overall yield
2.9 Intermediate
2.10 Transition state
2.11 Species
2.12 Free radical
2.13 Stoichiometric reaction
2.14 Catalytic reaction
2.15 Material balance
2.16 Electron balance
2.17 Nucleophile
2.18 Electrophile
2.19 Acid
2.20 Base
2.21 Acidity and pKa
2.22 Acid-base reaction
2.23 Reaction selectivity
2.24 Chemoselectivity
2.25 Regioselectivity
2.26 Stereoselectivity
2.27 Iteroselectivity
2.28 One-pot synthesis/Telescoping process
2.29 Cascade reaction
2.30 Multicomponent reaction
2.31 Flow chemistry
2.32 Atom economy
2.33 Green chemistry
2.34 Partial synthesis, total synthesis, and formal synthesis
2.35 Linear synthesis and convergent synthesis
2.36 Divergent synthesis
2.37 Click chemistry
2.38 Parallel synthesis
2.39 Solid phase synthesis
2.40 Combinatorial chemistry
2.41 Process chemist vs medicinal chemist

CHAPTER 3 GENERAL TERMS AND CONCEPTS IN MEDICINAL CHEMISTRY
3.1 What is a drug?
3.2 Drug discovery
3.3 Medicinal chemistry
3.4 Drug target
3.5 Enzyme
3.6 Receptor
3.7 Inhibitor
3.8 Activator
3.9 Drug design
3.10 Ligand-based drug design
3.11 Structure-based drug design
3.12 Lipinski's rule of five
3.13 Lead compound
3.14 Hit to lead
3.15 High-throughput screening
3.16 Pharmacophore
3.17 Affinity, efficacy, and potency
3.18 Structure-activity relationship (SAR)
3.19 Partition coefficient and Log P/Clog P
3.20 Drug candidate
3.21 Pre-clinical studies
3.22 Toxicity
3.23 Pharmacokinetics (PK) and pharmacodynamics (PD)
3.24 ADME
3.25 Bioavailability
3.26 Pharmacology
3.27 Formulation
3.28 Active pharmaceutical ingredient (API)
3.29 Drug stability
3.30 Prodrugs
3.31 Deuterium-containing drug
3.32 Antibody drug conjugate (ADC)
3.33 Good Laboratory Practice (GLP)
3.34 Good Manufacture Practice (GMP)
3.35 Chemistry, Manufacturing, and Controls (CMC)
3.36 Contract Research Organization (CRO)
3.37 Investigational New Drug Application (IND)
3.38 Clinical trials
3.39 New Drug Application (NDA)

CHAPTER 4 MECHANISM PROBLEMS FROM REACTIONS GIVE EXPECTED PRODUCTS
4.1 Formation of noncyclic compounds
4.2 Formation of hydrazine derivatives
4.3 Formation of cyclic alkane and derivatives
4.4 Formation of aromatic compounds
4.5 Formation of nonaromatic heterocycles
4.6 Formation of monocyclic aromatic heterocycles
4.7 Formation of bicyclic and polycyclic aromatic heterocycles
4.8 Miscellaneous

CHAPTER 5 MECHANISM PROBLEMS FROM REACTIONS GIVE UNEXPECTED, UNDESIRED, OR SIDE PRODUCTS
5.1 Formation of noncyclic alkane and derivatives
5.2 Formation of cyclic alkane and