Emil W. Ciurczak, Benoit Igne

Pharmaceutical and Medical Applications of Near-Infrared Spectroscopy (eBook, ePUB)

• Format: ePub

Produktbeschreibung

Since the completion of the first edition of this book, major developments have occurred in the pharmaceutical industry that have shaped the field of near-infrared (NIR) spectroscopy. A new initiative from the U.S. Food and Drug Administration (FDA) to modernize regulations of pharmaceutical manufacturing and drug quality has helped position NIR sp

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Produktdetails

• Verlag: Taylor & Francis eBooks
• Seitenzahl: 172
• Erscheinungstermin: 15. Dezember 2014
• Englisch
• ISBN-13: 9781040178911
• Artikelnr.: 72299421

Autorenporträt

Emil W. Ciurczak has degrees in Chemistry from Rutgers and Seton Hall Universities and has been in the pharmaceutical industry since 1970, performing method development. In 1983, he introduced NIR spectroscopy for pharmaceutical applications. He has consulted for numerous instrument companies. He has published over four dozen articles in refereed journals, over 150 magazine columns, and presented nearly two hundred technical papers. Since 2005, Emil has been Contributing Editor for Pharmaceutical Manufacturing magazine and wrote for Spectroscopy; (1987-2007). He has taught at colleges since 1979 and presented short courses in the US, Europe, South America, and Asia. He a consultant in the field of NIR and holds a dozen patents for NIR-based devices and software. He was a member of the PAT sub-committee (Validation) for the FDA and is a member of the PAT Expert Committee for the USP. He was the 2004 recipient of the EAS Achievements in NIR Award.

Beno Igne is a principal scientist at GlaxoSmithKline, King of Prussia, Pennsylvania. From 2010 to 2014, he worked as an industrial research coordinator at Duquesne University, Pittsburgh, Pennsylvania. He received his Ph.D. in Agricultural Engineering from Iowa State University, Ames, Iowa in 2009. He specializes in the implementation of Process Analytical Technologies.

Inhaltsangabe

Basic principles and theory. History. Early instrumentation. Spectroscopic
theory. Light-particle interaction. Instrumentation. Filter-based
instruments. Scanning grating monochromators. Interferometer-based
instruments. Acousto-optic tunable filters. Photodiode arrays. Specialty
and custom instruments. Optical parameter instrumentation. Strengths and
shortcomings of traditional types of equipment. Blend uniformity analysis.
Mixing. Discussion of reported work. Sampling and data handling.
Segregation, Demixing, and Particle Size. Granulation, Drying, and Coating.
Monitoring Granulation and Drying. Coating and Pelletization.
Pharmaceutical assays. Qualitative analysis. Quantitative analysis.
Determination of actives in tablets and capsules. Considerations for intact
dosage form analysis. Validation issues. International conference on
harmonization. Historical perspective. Medical applications. Blood glucose.
Blood oxygenation. Tissue. Major organs. Blood chemistry. Fetuses and
newborns. Cancer and precancer. Photon migration in tissues. Review
articles. Index.