Pharmaceutical Biotechnology (eBook, PDF)

A Focus on Industrial Application
Redaktion: Pessoa, Adalberto; Long, Paul Frederick; Vitolo, Michele

• Format: PDF

Produktbeschreibung

Pharmaceutical Biotechnology: A Focus on Industrial Application covers the development of new biopharmaceuticals as well as the improvement of those being produced. The main purpose is to provide background and concepts related to pharmaceutical biotechnology, together with an industrial perspective. This is a comprehensive text for undergraduates, graduates and academics in biochemistry, pharmacology and biopharmaceutics, as well as professionals working on the interdisciplinary field of pharmaceutical biotechnology. Written with educators in mind, this book provides teachers with background material to enhance their classes and offers students and other readers an easy-to-read text that examines the step-by-step stages of the development of new biopharmaceuticals.

Features:

• Discusses specific points of great current relevance in relation to new processes as well as traditional processes
• Addresses the main unitary operations used in the biopharmaceutical industry such as upstream and downstream
• Includes chapters that allow a broad evaluation of the production process

Dr. Adalberto Pessoa Jr. is Full Professor at the School of Pharmaceutical Sciences of the University of São Paulo and Visiting Senior Professor at King's College London. He has experience in enzyme and fermentation technology and in the purification processes of biotechnological products such as liquid-liquid extraction, cross-flow filtration and chromatography of interest to the pharmaceutical and food industries.

Dr. Michele Vitolo is Full Professor at the School of Pharmaceutical Sciences of the University of São Paulo. He has experience in enzyme technology, in immobilization techniques (aiming the reuse of the biocatalyst) and in the operation of membrane reactors for obtaining biotechnological products of interest to the pharmaceutical, chemical and food industries.

Dr. Paul F. Long is Professor of Biotechnology at King's College London and Visiting International Research Professor at the University of São Paulo. He is a microbiologist by training and his research uses a combination of bioinformatics, laboratory and field studies to discover new medicines from nature, particularly from the marine environment.

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Produktdetails

• Verlag: Taylor & Francis eBooks
• Seitenzahl: 400
• Erscheinungstermin: 15. Juli 2021
• Englisch
• ISBN-13: 9781000399844
• Artikelnr.: 61925629

Autorenporträt

Dr. Adalberto Pessoa Jr., Full professor at the School of Pharmaceutical Sciences of the University of São Paulo and Visiting Senior Professor at King's College London. He has experience in enzyme and fermentation technology and in the purification processes of biotechnological products, such as liquid-liquid extraction, cross-flow filtration and chromatography of interest to the pharmaceutical and food industries. Dr. Michele Vitolo, Full professor at the School of Pharmaceutical Sciences of the University of São Paulo. He has experience in enzyme technology, in immobilization techniques (aiming the reuse of the biocatalyst), and in the operation of membrane reactors for obtaining biotechnological products of interest to the pharmaceutical, Chemical, and food industries. [e-mail] Dr. Paul Long is Professor of Biotechnology at King's College London and Visiting International Research Professor at the University of São Paulo. Prof Long is a microbiologist by training and his research uses a combination of bioinformatics, laboratory and field studies to discover new medicines from nature, particularly from the marine environment.

Inhaltsangabe

Chapter 1 Fundamentals of
Biotechnology........................................................................................................................
1
Michele Vitolo
Chapter 2 Thermodynamics Applied to
Biomolecules....................................................................................................
29
Attilio Converti, Adalberto Pessoa Jr, Jônatas de Carvalho Silva, Rodrigo
Lira de Oliveira, and
Tatiana Souza Porto
Chapter 3 Expression Systems for the Production of Therapeutic Recombinant
Proteins...............................................43
Amanda Mizukami, Adalberto Pessoa Jr, and Kamilla Swiech
Chapter 4 Molecular Biology: Tools in Industrial Pharmaceutical
Biotechnology..........................................................55
Marina Gabriel Fontes and Gisele Monteiro
Chapter 5 Molecular Biology Tools: Techniques and
Enzymes.......................................................................................73
Marina Gabriel Fontes and Gisele Monteiro
Chapter 6 Bioinformatics Applied to the Development of Biomolecules of
Pharmaceutical Interest.............................89
Renata Bannitz Fernandes, Carlos Alexandre Breyer, Leonardo Schultz da
Silva, Pedro Henrique
Camargo Penna, Antônio Sérgio Kimus Braz, and Marcos Antonio de Oliveira
Chapter 7 Bioprocesses: Microorganisms and Culture
Media.......................................................................................115
Ricardo Pinheiro de Souza Oliveira and Adalberto Pessoa Jr
Chapter 8 Sterilization in Pharmaceutical
Biotechnology..............................................................................................133
Valéria C. Santos-Ebinuma, Fernanda de Oliveira, Nathalia V. Veríssimo,
Jorge F. B. Pereira, and
Adalberto Pessoa Jr
Chapter 9 Kinetics of Cell
Cultivation............................................................................................................................147
Aldo Tonso, Adalberto Pessoa Jr, and Michele Vitolo
Chapter 10 Bioreactors: Modes of
Operation...................................................................................................................157
Inês C. Roberto, Adalberto Pessoa Jr, and Aldo Tonso
Chapter 11 Agitation and Aeration: Oxygen Transfer and Cell
Respiration....................................................................181
Aldo Tonso, Thiago Olitta Basso, Adalberto Pessoa Jr, and Ricardo Pinheiro
de Souza Oliveira
Chapter 12 Mammalian Cell Culture
Technology...........................................................................................................195
Patrícia Barros dos Santos, Patrícia Léo, Ricardo Pinheiro de Souza
Oliveira, and
Marco Antonio Stephano
Chapter 13 Purification Process of
Biomolecules............................................................................................................
225
Adalberto Pessoa Jr and Beatriz Vahan Kilikian
Chapter 14 Lipopolysaccharides: Methods of Quantification and Removal from
Biotechnological Products................239
André M. Lopes, Jorge F. B. Pereira, João V. D. Molino, Felipe R. Lourenço,
and Adalberto Pessoa-Jr
Chapter 15 Enzymes: The Catalytic
Proteins...................................................................................................................257
Michele Vitolo
Chapter 16 Enzymes as Drugs and
Medicines................................................................................................................
265
Carlota de Oliveira Rangel-Yagui and Michele Vitolo
Chapter 17 Aspects of the Immobilization
Technique.....................................................................................................273
Michele Vitolo
Chapter 18 Biomolecules in Analytical
Methods............................................................................................................
287
João Henrique Picado Madalena Santos, Carlos Miguel Nóbrega Mendonça,
Francislene Andréia Hasmann, and Adalberto Pessoa Jr
Chapter 19 Nanotechnology and
Biopharmaceuticals.....................................................................................................
299
Alexsandra Conceição Apolinário, Valker Araujo Feitosa, João Henrique
Picado Madalena Santos,
and Carlota de Oliveira Rangel-Yagui
Chapter 20 Biosafety Applied in Pharmaceutical and Biotechnological
Processes.........................................................313
Camila Manoel Crnkovic, Celso Pereira Caricati, Ricardo Pinheiro de Souza
Oliveira, and
Marco Antonio Stephano
Chapter 21 Pharmaceutical Quality System for Biotechnology
Products........................................................................325
Laura de Oliveira Nascimento, Francisco Vitor Santos da Silva, and Marco
Antonio Stephano
Chapter 22 Techno-Economic Evaluation of Biotechnological Processes and
Pharmacoeconomic Analysis................355
Rafael da Gama Ferreira, Nicola Sgrignoli Fuganholi, Larissa Pereira
Brumano,
Adriano Rodrigues Azzoni, and Sindelia Freitas
Chapter 23 Perspectives for Pharmaceutical
Biotechnology............................................................................................369
Michele Vitolo