Pharmacology of Asthma (eBook, PDF)

Redaktion: Page, Clive P.; Barnes, Peter J.

• Format: PDF

Produktbeschreibung

This volume reviews in depth our current understanding of the mechanisms and treatment of asthma. The volume brings together recognised international authorities and is extensively referenced. It will provide an invaluable reference source for scientists, chest physicians and others with an interest in asthma.

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Produktdetails

• Verlag: Springer Berlin Heidelberg
• Seitenzahl: 320
• Erscheinungstermin: 6. Dezember 2012
• Englisch
• ISBN-13: 9783642758553
• Artikelnr.: 53093725

Inhaltsangabe

1 The Pathology of Asthma: An Overview.- A. Introduction.- B. Methods to Investigate the Pathology of Human Asthma.- C. Bronchial Epithelium and Inflammatory Cells in Asthmatic Patients Between Attacks.- D. Bronchial Epithelial Inflammation During an Asthma Attack.- E. Epithelial Regeneration.- F. Airway Smooth Muscle.- G. Bronchial Glands.- H. Neural Pathways.- I. Nerves and Other Airway Structures.- J. Bronchial Circulation.- K. Leakage of the Bronchial Vascular Bed in Patients with Asthma.- L. Conclusion.- References.- 2 The Contribution of Inflammatory Cells to the Pathogenesis of Asthma.- A. Inflammation and Inflammatory Cells.- B. Pathological Evidence for Inflammation in Asthma.- C. Microvascular Leakage.- D. Neutrophils.- E. Eosinophils.- F. Mast Cells and Basophils.- G. Monocytes and Macrophages (Mononuclear Phagocytes).- H. Platelets.- I. Lymphocytes.- J. Concluding Comments.- References.- 3 Inflammatory Mediators.- A. Introduction.- B. Histamine.- C. Cyclooxygenase Products.- D. Lipoxygenase Products.- E. PAF.- F. Kinins.- G. Adenosine.- H. Complement.- I. Serotonin.- J. Chemotactic Factors.- K. Oxygen Radicals.- L. Conclusions.- References.- 4 Pharmacology of Airway Smooth Muscle.- A. Introduction.- B. E/C Coupling Mechanisms.- C. E/C Uncoupling Mechamisms.- D. Future Trends in the Development of Bronchodilator Drugs.- References.- 5 Neural Mechanisms in Asthma.- A. Introduction.- B. Cholinergic Mechanisms.- C. Adrenergic Mechanisms.- D. NANC Nerves and Neuropeptides.- E. Conclusions.- References.- 6 Pharmacology and Therapeutics of ?-Adrenoceptor Agonists.- A. Introduction.- B. The Molecular Nature of the ?-Adrenoceptor and Its Relationship to Adenylate Cyclase.- C. Density and Distribution of ?-Adrenoceptors in the Lung.- D. Therapeutic Sites ofAction.- E. The Status of ?-Adrenoceptor Function in Asthma.- F. The Importance of ?2-Adrenoceptor Selectivity and Efficacy.- G. Adverse Reactions to ?-Adrenoceptor Agonists.- H. Therapeutic Actions of ?-Agonists.- I. Concluding Remarks.- References.- 7 Pharmacology of Anti-Asthma Xanthines.- A. Introduction.- B. Clinical Use.- C. Mode of Action of Xanthines.- D. Conclusion.- References.- 8 Glucocotricosteroids in Asthma.- A. Mechanism of Action of Glucocorticosteroids.- B. Clinical Use.- C. Future Developments.- References.- 9 Pharmacology of Prophylactic Anti-Asthma Drugs.- A. Cromoglycate and Nedocromil.- B. Ketotifen.- C. Pharmacological Analysis.- References.- 10 Pathophysiology and Pharmacology of Aspirin-Induced Asthma.- A. Introduction.- B. Definition and Main Clinical Features.- C. Pathogenesis.