Photoaffinity Labeling for Structural Probing Within Protein (eBook, PDF)

Redaktion: Hatanaka, Yasumaru; Hashimoto, Makoto

• Format: PDF

Produktbeschreibung

Provides a reliable strategy to probe molecular targets during the early stages of drug discovery and development

Describes the potential of updated photoaffinity labeling among chemical methods for the structural elucidation of proteins

Clarifies the chemical biology for the design and development of high-performance photoaffinity probes

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Produktdetails

• Verlag: Springer Japan
• Seitenzahl: 265
• Erscheinungstermin: 25. September 2017
• Englisch
• ISBN-13: 9784431565697
• Artikelnr.: 53058431

Autorenporträt

¿Yasumaru Hatanaka, PhD Executive Vice President, University of Toyama Toyama, Japan Makoto Hashimoto, PhD Graduate School of Agriculture, Hokkaido University Sapporo, Japan

Inhaltsangabe

Preface.- Chapter 1 Multifunctional Photoprobes for Identification of Ligand Sites within Biomolecules.- Chapter 2 Tag-Creation Approaches for Highly Efficient Profiling of Interacting Proteins and Domains.- Chapter 3 Recent Developments in Designing Compact Biological Photoprobes.- Chapter 4 Utilities of Anti-Ligand Antibody and Mass Spectrum to Elucidate Photolabelled Sites.- Chapter 5 Combination of Photoaffinity Label and Site-Directed Antibody for Target Proteins.- Chapter 6 Synthesis of diazirinyl photophore and optically pure diazirinylphenylalanines for photoaffinity labeling.- Chapter 7 Photoreactive biomacromolecules: preparation using photoreactive units and applications for analyzing biological interfaces.- Chapter 8 Covalently capturing protein interactions in living cells by site-specific incorporation of photo-cross-linkable amino acids.- Chapter 9 Use of hexose photolabels to reveal the structure and function of glucose transporters.- Chapter 10 The function of the mammalian peroxisome and analysis of the fatty acid oxidation system by photoaffinity labeling.- Chapter 11 Photoaffinity labeling methods to explore internalization mechanisms of arginine-rich cell-penetrating peptides.- Chapter 12 Photoaffinity Labeling in Drug Discovery Research.