Phylogenomics (eBook, ePUB)

Foundations, Methods, and Pathogen Analysis
Redaktion: Mokrousov, Igor; Shitikov, Egor

• Format: ePub

Produktbeschreibung

Phylogenomics: Foundations, Methods, and Pathogen Analysis offers a deep overview of phylogenomics as a field, compelling recent developments, and detailed methods and approaches for conducting new research. Early chapters introduce phylogenomic taxonomies of organisms and pathogens, phylogenomic networks, phylogenomics of virus virulence, and ancient DNA analysis, with a second section offering methods, detailed descriptions and step-by-step instruction in genome assembly and annotation, horizontal gene transfer studies, Bayesian evaluation, phylogenetic tree building, microbial evolution modeling, and molecular epidemiology.

The book's final section offers various examples of phylogenomic analysis across medically significant bacteria and viruses, including Yersinia pestis, Salmonella, Shigella, Vibrio cholera, and Mycobacterium tuberculosis, amongst others.

• Offers a full overview of phylogenetics and phylogenomics, from its foundations to methods and specialized case studies
• Presents methodologies and algorithms for phylogenomic research studies and analyzes medically significant microorganisms
• Considers examples of phylogenomic analysis across a range of medically significant pathogens
• Includes chapter contributions from leading international experts

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Produktdetails

• Verlag: Elsevier Science & Techn.
• Seitenzahl: 520
• Erscheinungstermin: 17. Mai 2024
• Englisch
• ISBN-13: 9780323913096
• Artikelnr.: 70718465

Inhaltsangabe

PART I. GENERAL TOPICS AND FOUNDATIONS 1. Phylogenomic analysis and the
origin and early evolution of viruses 2. Application of Next Generation
Sequencing for Genetic and Phenotypic Studies of Bacteria 3. Genomic
insight into deciphering bacterial outbreaks 4. Drug resistance in
bacteria, molecular mechanisms and evolution 5. Virulence evolution of
bacterial species PART II. METHODS IN THE PHYLOGENOMICS 6. Modeling
evolutionary changes of k-mer patterns of bacterial genomes 7. Clock Rates
and Bayesian Evaluation of Temporal Signal 8. Microbial evolutionary
reconstruction in the presence of mosaic sequences 9. Tools for SNP calling
and the way to deal with big datasets PART III. PHYLOGENOMICS OF SPECIFIC
PATHOGENS 10. Phylogenomics of Yersinia pestis 11. Salmonella Phylogenomics
12. The phylogenomics of Shigella spp. 13. Phylogenomic diversity within
Corynebacterium diphtheriae, a re-emerging threat to global public health
14. Phylogenomics of the East Asian lineage of Mycobacterium tuberculosis
15. Mycobacterium kansasii 16. Taxonomy and phylogenomics of Leptospira 17.
Phylogenomics and evolution of Measles virus 18. Phylogenomics of HIV-1 19.
Respiratory syncytial virus 20. Phylogenomics of Flaviviruses 21. How
clonal is Staphylococcus aureus? 22. Genomic research of ancient pathogens
in Central Asia 23. Subspecific nomenclature of the Cryptococcus
neoformans/gattii complex and the predominant clonal evolution (PCE) model
24. Phylogenomics of Mycobacterium leprae